scholarly journals De Novo Ceramide Synthesis Participates in the Ultraviolet B Irradiation-Induced Apoptosis in Undifferentiated Cultured Human Keratinocytes

2003 ◽  
Vol 120 (4) ◽  
pp. 662-669 ◽  
Author(s):  
Yoshikazu Uchida ◽  
Anna Di Nardo ◽  
Vanessa Collins ◽  
Peter M. Elias ◽  
Walter M. Holleran
Keyword(s):  
De Novo ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ceramide Synthesis ◽  
Ultraviolet B Irradiation ◽  
Induced Apoptosis

scholarly journals UVB protective effects of Sargassum horneri through the regulation of Nrf2 mediated antioxidant mechanism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eui Jeong Han ◽  
Seo-Young Kim ◽  
Hee-Jin Han ◽  
Hyun-Soo Kim ◽  
Kil-Nam Kim ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Human Keratinocytes ◽  
Underlying Mechanism ◽  
Ultraviolet B ◽  
Sargassum Horneri ◽  
Cellular Damage ◽  
Protective Effects ◽  
Skin Damage ◽  
Antioxidant Mechanism ◽  
Induced Apoptosis

AbstractThe present study aimed to evaluate the protective effect of a methanol extract of Sargassum horneri (SHM), which contains 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one (HTT) and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism. SHM significantly improved cell viability of UVB-exposed human keratinocytes by reducing the generation of intracellular reactive oxygen species (ROS). Moreover, SHM inhibited UVB exposure-induced apoptosis by reducing the formation of apoptotic bodies and the populations of the sub-G1 hypodiploid cells and the early apoptotic cells by modulating the expression of the anti- and pro-apoptotic molecules, Bcl-2 and Bax, respectively. Furthermore, SHM inhibited NF-κB p65 activation by inducing the activation of Nrf2/HO-1 signaling. The cytoprotective and antiapoptotic activities of SHM are abolished by the inhibition of HO-1 signaling. In further study, SHM restored the skin dryness and skin barrier disruption in UVB-exposed human keratinocytes. Based to these results, our study suggests that SHM protects the cells against UVB-induced cellular damages through the Nrf2/HO-1/NF-κB p65 signaling pathway and may be potentially useful for the prevention of UVB-induced skin damage.

A novel apoptosis inducer, apoptosis signal regulating kinase (ASK1), is involved in ultraviolet B-induced apoptosis of cultured human keratinocytes

1998 ◽  
Vol 16 ◽  
pp. S69 ◽  
Author(s):  
Koji Sayama ◽  
Hidenori Ichijo ◽  
Kenshi Yamasaki ◽  
Yashushi Hanakawa ◽  
Yuji Shirakata ◽  
...  
Keyword(s):  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Apoptosis Inducer ◽  
Induced Apoptosis

Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes

2008 ◽  
Vol 24 (3) ◽  
pp. 115-122 ◽  
Author(s):  
Mariela L. Paz ◽  
Daniel H. González Maglio ◽  
Federico S. Weill ◽  
Juanita Bustamante ◽  
Juliana Leoni
Keyword(s):  
Mitochondrial Dysfunction ◽  
Cellular Stress ◽  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet B Irradiation

scholarly journals Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bcl-2

FEBS Letters ◽  
2003 ◽  
Vol 540 (1-3) ◽  
pp. 125-132 ◽  
Author(s):  
Zerihun Assefa ◽  
Marjan Garmyn ◽  
Annelies Vantieghem ◽  
Wim Declercq ◽  
Peter Vandenabeele ◽  
...  
Keyword(s):  
Human Keratinocytes ◽  
Ultraviolet B ◽  
Ultraviolet B Radiation ◽  
Radiation Induced ◽  
Induced Apoptosis
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