Total abdominal hysterectomy and bilateral salpingo-oophorectomy. A sufficienttreatment for patients with low risk endometrial carcinoma

1997 ◽  
Vol 7 (5) ◽  
pp. 376-380 ◽  
Author(s):  
T. Leijon ◽  
P. Rosenberg ◽  
B. Boeryd
Keyword(s):  
Endometrial Carcinoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Low Risk

Endometrial Stage I Carcinoma Treated with Surgery and Adjuvant Irradiation: A Retrospective Analysis

1995 ◽  
Vol 81 (4) ◽  
pp. 256-260 ◽  
Author(s):  
Giovanni Boz ◽  
Antonino De Paoli ◽  
Roberto Innocente ◽  
Lino Del Pup ◽  
Renato Talamini ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Local Control ◽  
Combined Treatment ◽  
Distant Metastases ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Stage I ◽  
Lymph Node Sampling ◽  
Adjuvant Irradiation ◽  
Postoperative Irradiation

Aims and background Data from the literature show that the incidence of pelvic recurrences in poor prognosis endometrial carcinoma is significantly reduced by combined surgery and radiotherapy compared to surgery alone. Methods In this paper we analyze the results of the combined treatment surgery and adjuvant irradiation in patients with endometrial carcinoma with regard to survival, site of progression, and toxicity. The surgical treatment consisted of total abdominal hysterectomy and bilateral salpingo-oophorectomy in 40 patients. Pelvic and para-aortic node dissection was performed in 19 patients and lymph node sampling in 5. Results Overall 5-year survival was 85%. One patient had local failure, and 5 patients with local control of disease had distant metastases. Toxicity was mild and transient. Conclusions Our experience confirms the data of the literature. Postoperative irradiation is a safe and well-tolerated treatment that can achieve a good local control in high risk, stage I, endometrial carcinoma. The control of distant metastases remains an open question.

Pembrolizumab as adjuvant therapy in a patient with Lynch syndrome with synchronous mixed clear cell carcinoma of ovarian origin and endometroid endometrial carcinoma

2021 ◽  
Vol 14 (11) ◽  
pp. e245497
Author(s):  
Kathleen Batty ◽  
Minmin Li ◽  
Sally Baron-Hay
Keyword(s):  
Lynch Syndrome ◽  
Cell Carcinoma ◽  
Endometrial Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Total Abdominal Hysterectomy ◽  
Complete Response ◽  
Abdominal Hysterectomy ◽  
High Index Of Suspicion ◽  
Percutaneous Thrombectomy

A 48-year-old woman was diagnosed with synchronous mixed clear cell carcinoma of ovarian origin and endometroid endometrial carcinoma after presenting with intermenstrual bleeding for 2 years prior. Shortly after diagnosis she became progressively unwell requiring intensive care unit admission with respiratory failure, pleural effusions and pulmonary emboli. Following a total abdominal hysterectomy, bilateral salpingo-oophorectomy, laparotomy and emergency percutaneous thrombectomy, she remained critically unwell and was deemed not safe for chemotherapy. Given a high index of suspicion for Lynch syndrome, the patient was treated with adjuvant pembrolizumab and achieved a complete response. Lynch syndrome was subsequently confirmed through germline genetic testing. The patient made an excellent recovery and remains disease-free at 23 months.

Endometrial cancer metastasis presenting as a grossly swollen toe

2003 ◽  
Vol 13 (6) ◽  
pp. 909-911 ◽  
Author(s):  
Z. A. Ali ◽  
J. A. Wimhurst ◽  
A. A. Ali ◽  
M. E. Tempest ◽  
D. J. Edwards
Keyword(s):  
Endometrial Carcinoma ◽  
Cancer Metastasis ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Histologic Diagnosis ◽  
First Case ◽  
Stage Disease ◽  
The Face ◽  
Carcinoma Metastasis ◽  
Peripheral Skeleton

Metastasis to the peripheral skeleton, especially in the face of low stage disease, is rare. This report describes the case of a 77-year-old lady with stage IC disease who underwent curative total abdominal hysterectomy and bilateral salpingo-oopherectomy 2 years prior to presenting with a painless gigantism of her fourth toe. A histologic diagnosis of dedifferentiated endometrial metastasis with sarcomatous differentiation was made following amputation of the toe. Osseous metastasis to bone is discussed in the context of endometrial carcinoma and the literature reviewed. This paper reports the first case of endometrial carcinoma metastasis presenting as gross swelling of a toe.

scholarly journals Systemic Lymphadenectomy Cannot Be Recommended for Low-Risk Corpus Cancer

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Takao Hidaka ◽  
Akitoshi Nakashima ◽  
Tomoko Shima ◽  
Toru Hasegawa ◽  
Shigeru Saito
Keyword(s):  
Medical Records ◽  
Disease Free Survival ◽  
Myometrial Invasion ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Low Risk ◽  
Paraaortic Lymph Node ◽  
Free Survival ◽  
Lymph Node Swelling ◽  
Disease Free

Objective. The objective of this study is to ascertain whether omission of lymphadenectomy could be possible when uterine corpus cancer is considered low-risk based on intraoperative pathologic indicators.Patient and Methods. Between 1998 and 2007, a total of 83 patients with low risk corpus cancer (endometrioid type, grade 1 or 2, myometrial invasion 50%, and no intraoperative evidence of macroscopic extrauterine spread, including pelvic and paraaortic lymph node swelling and adnexal metastasis) underwent the total abdominal hysterectomy and bilateral salpingo-oophorectomy without lymphadenectomy. A retrospective review of the medical records was performed, and the disease-free survival (DFS), overall survival (OS), peri- and postoperative morbidities and complications were evaluated.Results. The 5-year DFS rates and the 5-year OS rates were 97.6% and 98.8%, respectively. No patient presented postoperative leg lymphedema and deep venous thrombosis.Conclusion. Omission of lymphadenectomy did not worsen the DFS or OS. The present findings suggest that systemic lymphadenectomy could be omitted in low-risk endometrial carcinoma.

Surgical pathologic staging in apparent stage I endometrial carcinoma

1993 ◽  
Vol 3 (6) ◽  
pp. 373-384 ◽  
Author(s):  
C. Mangioni ◽  
G. De Palo ◽  
E. Marubini ◽  
M. Del Vecchio
Keyword(s):  
Endometrial Carcinoma ◽  
Myometrial Invasion ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Multicenter Trial ◽  
Stage I ◽  
Surgical Staging ◽  
Poor Differentiation ◽  
Stage Ia ◽  
Deep Myometrial Invasion

A multicenter trial on apparent stage I endometrial carcinoma was performed to establish an intensive surgical staging, to formulate a treatment on the basis of the pathological extent of the disease and to determine the effectiveness of adjuvant medroxyprogesterone acetate therapy. The results of the first objective on 1,055 patients are herein reported. All patients had total abdominal hysterectomy, bilateral salpingo-oophorectomy, colpectomy of the superior third, and biopsy of lymph nodes positive or doubtful at radiological imaging or on surgical inspection. On the basis of the pathologic extent of the disease, patients were classified into five categories: disease outside the uterine corpus (RE); disease limited to endometrium (RO); disease with inner myometrial invasion and high or moderate grade (R1); disease with deep myometrial invasion or poor differentiation (R2); disease with positive retroperitoneal nodes (R3). One hundred and forty-six patients were RE, 163 RO, 382 R1, 341 R2 and 23 R3. The results showed a clinical understaging in 16% of the cases. According to the new FIGO classification, the relapse-free survival at 84 months was 96% for patients at stage IA, 92% for patients with stage IB-C, 86% for stage IIA-B, 76% for stage IIIA-B and 74% for patients at stage IIIC. These data confirm the importance of an intensive surgical staging in apparent stage I endometrial carcinoma.

Undifferentiated endometrial carcinoma of the uterus: marked effect of chemotherapy with tetrahydropyranyl-adriamycin, paclitaxel, and carboplatin

2004 ◽  
Vol 14 (2) ◽  
pp. 388-394 ◽  
Author(s):  
M. Hayashi ◽  
Y. Ueda ◽  
T. Takimoto ◽  
T. Ohkura
Keyword(s):  
Endometrial Carcinoma ◽  
Poor Prognosis ◽  
Rare Case ◽  
Marked Effect ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Remarkable Effect ◽  
Tumor Tissues ◽  
Residual Carcinoma ◽  
Giant Tumor

Undifferentiated endometrial carcinoma of the uterus is rare, and is thought to show a poor prognosis. To date, there is no consensus as to the optimal chemotherapy for this carcinoma. We report a rare case of this carcinoma in a patient who was treated surgically in combination with chemotherapy using a regimen designed by us. This chemotherapy consists of tetrahydropyranyl-adriamycin, paclitaxel, and carboplatin. This regimen is called TTJ [tetrahydropryanyl-adriamycin, taxan (paclitaxel), JM-8 (carboplatin)] chemotherapy and showed a marked effect. The patient was a 52-year-old woman with a giant tumor of the uterus measuring 28 × 18 × 13 cm and weighing 3386 g. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy, but residual carcinoma remained on the surface of the small intestine. Pathologically tumor tissues comprised the whole uterus except for the uterine cervix and there were tumor tissues in the omentum. She was treated with six courses of TTJ chemotherapy without major side-effects. Currently, she remains alive without metastasis 41 months after hysterectomy. This report describes a rare case of undifferentiated endometrial carcinoma of the uterus and introduces TTJ chemotherapy resulting in the remarkable effect on this carcinoma.

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