Standardization of Plasma Brain Natriuretic Peptide Concentrations in Older Japaneseâ€”Relationship to Latent Renal Dysfunction and Ischemic Heart Disease

Abstract Background: Previous studies suggested that plasma B-type natriuretic peptide (BNP) level was often elevated in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and was associated with increased mortality. However, most studies did not consider the fact that conditions such as coronary ischemic heart disease can also increase BNP level. Therefore, we aimed to explore the association between BNP level and in-hospital mortality in patients with AECOPD without a history of coronary ischemic heart disease.Methods: In this retrospective cohort study, patients who were diagnosed with AECOPD using International Statistical Classification of Diseases and Related Health Problems, Nineth Revision (ICD-9 codes) between January 2017 and December 2019. All data were obtained from electronic patient files and medical data intelligence platform of Jinan Central Hospital. BNP level was determined within 24 hours after admission, and the value was log2 transformed. The primary outcome was in-hospital mortality, and the secondary outcome was a composite outcome of in-hospital mortality or invasive mechanical ventilation.Results: A total of 300 patients were included in this study. Univariate cox regression analysis showed that the unadjusted HRs of the primary and secondary outcomes were 1.85 (95% CI, 1.39-2.47) and 1.45 (95% CI, 1.20-1.75), respectively. After adjustment for age, sex, past medical history, smoking status, drinking status, CURB65 (Confusion, Urea > 7mmol/L, Respiratory rate≥30/min, Blood pressure systolic < 90 mmHg or diastolic <60 mmHg and age > 65 years), arterial partial pressure of O2(PaO2), the adjusted HRs of the primary and secondary outcomes were 3.65 (95% CI, 2.54-5.26) and 1.43 (95% CI, 1.14-1.97), respectively. The results of subgroup analysis by age, sex, and lung function were robust. This study was retrospective, so there was no clinical trial registration.Conclusions: The plasma log2BNP level was significantly associated with in-hospital mortality and a composite outcome of in-hospital mortality or invasive mechanical ventilation.

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Plasma Norepinephrine and Atrial Natriuretic Peptide Levels During Exercise Stress Test of Patients with Ischemic Heart Disease

Endocrinology of the Heart ◽

10.1007/978-3-642-83858-3_31 ◽

1989 ◽

pp. 188-190

Author(s):

W. Osterode ◽

D. H. Petzl ◽

E. Hartter ◽

H. Böhm

Keyword(s):

Heart Disease ◽

Atrial Natriuretic Peptide ◽

Ischemic Heart Disease ◽

Natriuretic Peptide ◽

Stress Test ◽

Exercise Stress Test ◽

Ischemic Heart ◽

Exercise Stress ◽

Plasma Norepinephrine ◽

Atrial Natriuretic

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Brain natriuretic peptide in pregnant women with heart disease

Obstetric Medicine ◽

10.1177/1753495x18819351 ◽

2019 ◽

Vol 13 (1) ◽

pp. 25-29

Author(s):

Karanvir Singh ◽

Pooja Sikka ◽

Vanita Suri ◽

Rishikesh Prasad ◽

Madhu Khullar ◽

...

Keyword(s):

Heart Failure ◽

Adverse Event ◽

Heart Disease ◽

Adverse Events ◽

Brain Natriuretic Peptide ◽

Pregnant Women ◽

Natriuretic Peptide ◽

Cardiac Events ◽

Plasma Brain Natriuretic Peptide ◽

Rheumatic Heart

Background Plasma brain natriuretic peptide levels were prospectively studied in pregnant women with heart disease. Methods Fifty pregnant women with heart disease and 25 controls were evaluated at 24 weeks or under, 30–32 weeks, 34 weeks or more of gestation, and 6 weeks postpartum. Adverse maternal cardiac events were hospitalization for worsening heart failure, stroke, and death. Results Thirty-eight (76%) women had rheumatic heart disease. Plasma brain natriuretic peptide levels were (in cases and controls) 118.3 ± 46.5 pg/ml and 66.3 ± 15.9 pg/ml (at 24 weeks or under), 124.8 ± 30.4 pg/ml and 68.4 ± 16.5 pg/ml (30–32 weeks), 135.8 ± 34.9 pg/ml and 68.6 ± 15.6 pg/ml (34 weeks or more), and 110.1 ± 21.9 pg/ml and 65.0 ± 16.1 pg/ml (6 weeks postpartum) (p = .0001). Eighteen women had adverse events. Of these, only 1 had a level less than 100 pg/ml, 12 were between 100 and 200 pg/ml, and 5 more than 200 pg/ml. Conclusions Plasma brain natriuretic peptide levels were higher in women with heart disease at all periods of gestation as well as six weeks postpartum. No woman with a plasma brain natriuretic peptide levels of 98 pg/ml or less had an adverse event.

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