scholarly journals Approximating Component Selection

2005 ◽  
Author(s):  
M.R. Fox ◽  
D.C. Brogan ◽  
P.F. Reynolds
Keyword(s):  
Component Selection

The Importance of Maximizing Grid Electricity Usage in the Component Selection and Design of a Midsize PHEV

2013 ◽  
Author(s):  
Trevor Fayer ◽  
Trevor Crain ◽  
Brian Fabien ◽  
Per Reinhall
Keyword(s):  
Component Selection

Liposomes with cerasome-forming lipids as gene therapy vectors

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Electrostatic Interactions ◽  
Membrane Surface ◽  
Immunological Response ◽  
Basic Research ◽  
Systemic Circulation ◽  
Cationic Lipids ◽  
Transport Systems ◽  
Component Selection ◽  
Polar Groups ◽  
Gene Therapy Vectors

Basic research focuses on liposome transport systems as non-viral ways of transferring genetic and therapeutic substances. Due to electrostatic interactions between positive polar groups of cationic lipids and the negatively charged cell membrane surface, nucleic acids may readily be transported into cells as part of lipoplexes. Cationic liposomes, however, have a number of well-known problems, including low stability, toxicity, and a potential for severe immunological response. Recent research has revealed, however, that by increasing the system with additional components such as cerasome-forming lipids, these problems may be solved. They aid in the prolongation of the release of a beneficial liposome load in cells by increasing vesicle stability in the systemic circulation. This circumstance broadens the applications for liposomal systems. As a consequence, using varied lipids can create numerous liposomes for use in a range of medical fields. Nonviral delivery approaches based on hybrid liposomes with suitable structural component selection may be a possible response to a number of medical concerns, and further study is urgently needed.

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