scholarly journals Magnetic soy protein isolate–bovine serum albumin nanoparticles preparation as a carrier for inulinase immobilisation

2018 ◽  
Vol 12 (5) ◽  
pp. 633-639 ◽  
Author(s):  
Mohaddeseh Mikani ◽  
Homa Torabizadeh ◽  
Reza Rahmanian
Drug Research ◽  
2020 ◽  
Vol 70 (05) ◽  
pp. 183-187
Author(s):  
Mohammad Shariq ◽  
Saba Parveen ◽  
Arshiya Shamim ◽  
Farogh Ahsan ◽  
Poonam Kushwaha ◽  
...  

AbstractPast few decades have emerged as the era of nanotechnology worldwide leading to an extensive research in pharmaceutical science as well as other fields. Nanoformulations have shown a promising future in therapeutics and theronostics. Protein based nanoformulations attracting attention in research as it can be used as therapeutics as well as carrier. Carrier based protein nanoformulatios are capable of accommodating range of therapeutics such as dyes, drugs, contrast agents and inorganic nanoclusters makings its application vast. The nano size of formulation enables it to reach the desired places by some modification. This paper reviewed the various protein based nanoformulation. Human serum albumin, Bovine serum albumin, soy protein isolate, phycocyanin, casein, bromelein, collagen and sericin based nanoformulations are briefly discussed. Various limitations of these proteins can be diminished by developing it in nano form and emerged as promising candidate as carrier as well as therapeutics in drug delivery advancements.


Luminescence ◽  
2014 ◽  
Vol 30 (5) ◽  
pp. 583-591 ◽  
Author(s):  
Jitendra Wagh ◽  
Kuldeep J. Patel ◽  
Parth Soni ◽  
Krutika Desai ◽  
Pratik Upadhyay ◽  
...  

2021 ◽  
Vol 18 ◽  
Author(s):  
Monica Joshi ◽  
Khushwant S. Yadav ◽  
Bala Prabhakar

Background: Rifampicin is one of the first line drugs used for tuberculosis therapy. The therapy lasts for a long time. Thus, there is a need to develop sustained release formulation of rifampicin for intravenous application. Aim: This study is focused on preparing rifampicin loaded bovine serum albumin nanoparticles (RIF BSA NPs) suitable for intravenous application using systematic quality by design (QbD) approach. Objectives: The main objective of this study is optimizing particle size and entrapment efficiency of rifampicin loaded bovine serum albumin nanoparticles (RIF BSA NPs) and making it suitable for intravenous application using QbD approach. Methods: Quality target product profile was defined along with critical quality attributes (CQAs) for the formulation. 32 factorial design was used for achieving the predetermined values of CQAs, i.e., mean particle size <200 nm and percent entrapment efficiency>50%. Incubation time of drug with colloidal albumin solution and ratio of rifampicin: albumin, were selected as independent variables. Check point analysis was performed to confirm the suitability of regression model for optimization. Results: : The optimized RIF BSA NPs were characterized by FTIR, DSC, 1H NMR techniques. The NPs observed by transmission electron microscopy were spherical in shape. The rifampicin release could be sustained for 72 hours from BSA NPs matrix. RIF BSA NPs dispersion was stable at 5 ± 3°C for 72 hours. Non-toxicity of nanoparticles to RAW 264.7 cell line was proved by MTT assay. Conclusion: Development of RIF BSA NPs with desired quality attributes was possible by implementing QbD approach. The optimized formulation suitable for intravenous application can potentially improve the therapeutic benefits of rifampicin.


Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Haipeng Wang ◽  
Shuilin Sun ◽  
Yu Zhang ◽  
Jiayi Wang ◽  
Shouhua Zhang ◽  
...  

2019 ◽  
Vol 54 (11) ◽  
pp. 8613-8626 ◽  
Author(s):  
Danfeng Wang ◽  
Na Liang ◽  
Yoshiaki Kawashima ◽  
Fude Cui ◽  
Pengfei Yan ◽  
...  

2015 ◽  
Vol 9 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Ali Jebali ◽  
Seyedhossein Hekmatimoghaddam ◽  
Bahram Kazemi ◽  
Jesus Martinez De La Fuente

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