Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel

2019 ◽  
Vol 54 (11) ◽  
pp. 8613-8626 ◽  
Author(s):  
Danfeng Wang ◽  
Na Liang ◽  
Yoshiaki Kawashima ◽  
Fude Cui ◽  
Pengfei Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bovine Serum ◽  
Potential Drug ◽  
Albumin Nanoparticles

Bovine serum albumin/gold nanoparticles as a drug delivery system for Curcumin: experimental and computational studies

2019 ◽  
Vol 38 (15) ◽  
pp. 4644-4654 ◽  
Author(s):  
Bahareh Khodashenas ◽  
Mehdi Ardjmand ◽  
Mazyar Sharifzadeh Baei ◽  
Ali Shokuhi Rad ◽  
Azim Akbarzadeh Khiyavi
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bovine Serum ◽  
Computational Studies

Modeling the Interaction of Interferon α-1b to Bovine Serum Albumin as a Drug Delivery System

2014 ◽  
Vol 118 (29) ◽  
pp. 8566-8574 ◽  
Author(s):  
Qi Luo ◽  
Yihui Wang ◽  
Hongge Yang ◽  
Chang Liu ◽  
Yuan Ding ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bovine Serum ◽  
Interferon Α

Photodynamic therapy using silicon phthalocyanine conjugated with bovine serum albumin as a drug delivery system

Laser Physics ◽  
2021 ◽  
Vol 31 (7) ◽  
pp. 075601
Author(s):  
E P O Silva ◽  
N M Ribeiro ◽  
M A G Cardoso ◽  
C Pacheco-Soares ◽  
M Beltrame Jr
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bovine Serum ◽  
Silicon Phthalocyanine

Folate-modified bexarotene-loaded bovine serum albumin nanoparticles as a promising tumor-targeting delivery system

2014 ◽  
Vol 2 (47) ◽  
pp. 8361-8371 ◽  
Author(s):  
Lisi Qi ◽  
Yuanyuan Guo ◽  
Jingjing Luan ◽  
Dianrui Zhang ◽  
Zhongxi Zhao ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Delivery System ◽  
Bovine Serum ◽  
Tumor Targeting ◽  
Albumin Nanoparticles ◽  
Targeting Delivery

Preparation and formulation optimization of methotrexate-loaded human serum albumin nanoparticles modified by mannose

2021 ◽  
Vol 28 ◽  
Author(s):  
Zhenyu Chen ◽  
Zhongling Luo ◽  
Jiayao Lyu ◽  
Jianxin Wang ◽  
Zhongbing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System ◽  
Circulation Time ◽  
Independent Variables ◽  
Albumin Nanoparticles

Background: Methotrexate (MTX) is the representative drug among the disease-modifying anti-rheumatic drugs. But the conventional treatment with MTX showed many limitations and side effects. Objective: To strengthen the targeting ability and circulation time of MTX in the treatment of rheumatoid arthritis, the present study focused on developing a novel drug delivery system of methotrexate-loaded human serum albumin nanoparticles (MTX-NPs) modified by mannose, which referred as MTX-M-NPs. Methods: Firstly, mannose-derived carboxylic acid was synthesized and further modified on the surface of MTX-NPs to prepare MTX-M-NPs. The formulation of nanoparticles was optimized by method of central composite design (CCD), with the drug lipid ratio, oil-aqueous ratio, and cholesterol or lecithin weight as the independent variables. The average particle size and encapsulation efficiency were the response variables. Response of different formulations was calculated and the response surface diagram, contour diagram and mathematical equation were used to relate the dependent and independent variables to predict the optimal formula ratio. The uptake of MTX-M-NPs by neutrophils was studied through the laser confocal detection. Further, MTX-M-NPs was subjected to assess the pharmacokinetics profile after intravenous injection with Sprague-Dawley rats. Results: This targeting drug delivery system was successfully developed. Results from Nuclear Magnetic Resonance and Fourier Transform Infrared Spectroscopy analysis can verify the successful preparation of this drug delivery system. Based on the optimized formula, MTX-M-NPs was prepared with a particle size of 188.17 ± 1.71 nm and an encapsulation rate of 95.55 ± 0.33%. MTX-M-NPs displayed significantly higher cellular uptake than MTX-NPs. The pharmacokinetic results showed that MTX-M-NPs could prolong the in vivo circulation time of MTX. Conclusion: This targeting drug delivery system laid a promising foundation for the treatment of RA.

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