Chapter 4 Clinical MRI Mapping

AbstractGadolinium based contrast agents (GBCAs) are widely used in clinical MRI since the mid-1980s. Recently, concerns have been raised that trace amounts of Gadolinium (Gd), detected in brains even long time after GBCA application, may cause yet unrecognized clinical consequences. We therefore assessed the behavioral phenotype, neuro-histopathology, and Gd localization after repeated administration of linear (gadodiamide) or macrocyclic (gadobutrol) GBCA in rats. While most behavioral tests revealed no difference between treatment groups, we observed a transient and reversible decrease of the startle reflex after gadodiamide application. Residual Gd in the lateral cerebellar nucleus was neither associated with a general gene expression pathway deregulation nor with neuronal cell loss, but in gadodiamide-treated rats Gd was associated with the perineuronal net protein aggrecan and segregated to high molecular weight fractions. Our behavioral finding together with Gd distribution and speciation support a substance class difference for Gd presence in the brain after GBCA application.

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Monitoring treatment effects in lung cancer-bearing mice: clinical CT and clinical MRI compared to micro-CT

European Radiology Experimental ◽

10.1186/s41747-020-00160-7 ◽

2020 ◽

Vol 4 (1) ◽

Cited By ~ 1

Author(s):

Judith E. Spiro ◽

Miriam Rinneburger ◽

Dennis M. Hedderich ◽

Mladen Jokic ◽

Hans Christian Reinhardt ◽

...

Keyword(s):

Lung Cancer ◽

Treatment Effects ◽

Micro Ct ◽

Monitoring Treatment ◽

Clinical Mri

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Differential diagnosis of peripheral facial nerve palsy: a retrospective clinical, MRI and CSF-based study

Journal of Neurology ◽

10.1007/s00415-019-09387-w ◽

2019 ◽

Vol 266 (10) ◽

pp. 2488-2494 ◽

Cited By ~ 12

Author(s):

Julia Zimmermann ◽

Sarah Jesse ◽

Jan Kassubek ◽

Elmar Pinkhardt ◽

Albert C. Ludolph

Keyword(s):

Differential Diagnosis ◽

Facial Nerve ◽

Nerve Palsy ◽

Facial Nerve Palsy ◽

Peripheral Facial Nerve Palsy ◽

Clinical Mri

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High field clinical MRI neuroimaging

2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro ◽

10.1109/isbi.2010.5490280 ◽

2010 ◽

Author(s):

M.A. van Buchem ◽

J. van der Grond ◽

M. Versluis ◽

M.J.P. van Osch ◽

W. Teeuwisse ◽

...

Keyword(s):

High Field ◽

Clinical Mri

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P1-269: Application of Brain Atrophy Lesion Index (BALI) to Common Clinical MRI Sequences: Evaluation of Whole Brain Structural Changes in Aging and Dementia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2016.06.1019 ◽

2016 ◽

Vol 12 ◽

pp. P518-P518

Author(s):

Xiaowei Song ◽

Hui Guo ◽

Ryan C.N. D'Arcy ◽

William Siu ◽

John Diggle ◽

...

Keyword(s):

Brain Atrophy ◽

Structural Changes ◽

Whole Brain ◽

Mri Sequences ◽

Clinical Mri ◽

Lesion Index

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Clinical, MRI, and Histopathological Features of Hypothalamic Neuronal Hamartoma in a Young Vizsla

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-7083 ◽

2021 ◽

Author(s):

Leonardo Bibbiani ◽

Sara Canal ◽

Daiana Marabese ◽

Maria T. Mandara ◽

Greta Foiani ◽

...

Keyword(s):

Congenital Malformations ◽

Histopathological Examination ◽

Middle Cranial Fossa ◽

Clinical Imaging ◽

First Report ◽

Histopathological Features ◽

Neurological Signs ◽

Cranial Fossa ◽

The Brain ◽

Clinical Mri

ABSTRACT Human hypothalamic neuronal hamartomas are rare, nonprogressive, congenital malformations of the hypothalamus that do not expand or metastasize to other locations. A 1 yr old female vizsla was presented for progressive intracranial multifocal neurological signs already present since adoption at 3 mo of age. MRI of the brain showed an ill-defined, intra-axial, space-occupying, nonenhancing lesion located in the ventral middle cranial fossa. Histopathological examination was consistent with hypothalamic neuronal hamartoma. This is the first report describing clinical, imaging, and histopathological features of a hypothalamic neuronal hamartoma in a dog. These findings are compared with the human counterparts.

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