scholarly journals Next Generation of HEP CPU Benchmarks

2019 ◽  
Vol 214 ◽  
pp. 08011
Author(s):  
Domenico Giordano ◽  
Manfred Alef ◽  
Michele Michelotto
Keyword(s):  
Working Group ◽  
Next Generation ◽  
Programming Paradigms ◽  
Data Centres ◽  
Computing Capacity

As of 2009, HEP-SPEC06 (HS06) is the benchmark adopted by the WLCG community to describe the computing requirements of the LHC experiments, to assess the computing capacity of the WLCG data centres and to procure new hardware. In the recent years, following the evolution of CPU architectures and the adoption of new programming paradigms, such as multi-threading and vectorization, it has turned out that HS06 is less representative of the relevant applications running on the WLCG infrastructure. Meanwhile, in 2017 a new SPEC generation of benchmarks for CPU intensive workloads has been released: SPEC CPU 2017. This report summarises the findings of the HEPiX Benchmarking Working Group in comparing SPEC CPU 2017 and other HEP benchmarks with the typical WLCG workloads mixes.

scholarly journals The integration of emerging omics approaches to advance precision medicine: How can regulatory science help?

2018 ◽  
Vol 2 (5) ◽  
pp. 295-300
Author(s):  
Joan E. Adamo ◽  
Robert V. Bienvenu ◽  
F. Owen Fields ◽  
Soma Ghosh ◽  
Christina M. Jones ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Precision Medicine ◽  
Working Group ◽  
Regulatory Science ◽  
Translational Science ◽  
Next Generation ◽  
Clinical Validity ◽  
Knowledge Gaps ◽  
Recent Advances ◽  
Generation Sequencing

Building on the recent advances in next-generation sequencing, the integration of genomics, proteomics, metabolomics, and other approaches hold tremendous promise for precision medicine. The approval and adoption of these rapidly advancing technologies and methods presents several regulatory science considerations that need to be addressed. To better understand and address these regulatory science issues, a Clinical and Translational Science Award Working Group convened the Regulatory Science to Advance Precision Medicine Forum. The Forum identified an initial set of regulatory science gaps. The final set of key findings and recommendations provided here address issues related to the lack of standardization of complex tests, preclinical issues, establishing clinical validity and utility, pharmacogenomics considerations, and knowledge gaps.

scholarly journals Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: Report from the 17th International HLA and Immunogenetics Workshop

2019 ◽  
Vol 80 (7) ◽  
pp. 449-460 ◽  
Author(s):  
Lisa E. Creary ◽  
Sandra G. Guerra ◽  
Winnie Chong ◽  
Colin J. Brown ◽  
Thomas R. Turner ◽  
...  
Keyword(s):  
Cell Lines ◽  
Working Group ◽  
Hla Typing ◽  
Lymphoblastoid Cell Lines ◽  
Next Generation

scholarly journals LHC Dark Matter Working Group: Next-generation spin-0 dark matter models

2020 ◽  
Vol 27 ◽  
pp. 100351 ◽  
Author(s):  
Tomohiro Abe ◽  
Yoav Afik ◽  
Andreas Albert ◽  
Christopher R. Anelli ◽  
Liron Barak ◽  
...  
Keyword(s):  
Dark Matter ◽  
Working Group ◽  
Next Generation

Characterization of G12 Sandwich ELISA, a Next-Generation Immunoassay for Gluten Toxicity

2012 ◽  
Vol 95 (2) ◽  
pp. 372-376 ◽  
Author(s):  
Elisabeth Halbmayr-Jech ◽  
Elisabeth Hammer ◽  
Richard Fielder ◽  
Jacqueline Coutts ◽  
Adrian Rogers ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Celiac Disease ◽  
Working Group ◽  
Sandwich Elisa ◽  
Extraction Methods ◽  
Cross Reactivity ◽  
Next Generation ◽  
Preliminary Results ◽  
Sample Extraction

Abstract In this work, a monoclonal antibody called G12, raised against the most immunotoxic peptide to celiac disease patients, was used to develop a sandwich ELISA. Preliminary results on cross-reactivities, recoveries, and extraction methods of the new assay are presented. The assay calibration was performed using material from the Prolamin Working Group. The antibody's specificity was determined by cross-reactivity studies on different grains, nuts, oils, and starches. Recovery of the assay was determined by spiking experiments on common food matrixes, as well as on problematic matrixes. Furthermore, sample extraction methods using ethanol, cocktail solution, and a proprietary buffer have been compared.

Validation of the Accessible Lavatory Recommendations for the Next Generation of Accessible Passenger Rail Cars

2014 ◽  
Author(s):  
Kate Hunter-Zaworski ◽  
Robin Kiff ◽  
Melissa Shurland
Keyword(s):  
Working Group ◽  
Full Scale ◽  
Design Parameters ◽  
Next Generation ◽  
Passenger Rail ◽  
Rail Vehicles ◽  
Virtual Models ◽  
Mobility Devices ◽  
Project Objectives ◽  
Wheeled Mobility

The accessible lavatory specifications are part of the recommendations for specifications of the Next Generation of Passenger Rail Vehicles. These are being validated using virtual tools to model wheeled mobility aids with occupants using “concept” lavatories to determine optimal spatial configurations for accessible lavatories on board passenger rail vehicles. The overall project objectives included the development of accessibility specifications for the single and bi-level cars that can be used by the rail manufacturing industry to produce vehicles for high speed (HSR) and intercity passenger rail. The specific objective includes developing “virtual” models of accessible lavatories that incorporate the recommended accessibility specifications reported in paper No. JRC 2013-2554 in the proceedings of the 2013 Joint Rail Conference. The “virtual” models will permit both calibration and validation of the recommendations that were submitted to the PRII A Accessibility Working Group (the Working Group). The Working Group requested that prior to acceptance of the recommendations that they be validated and calibrated. The use of “virtual” validation tools and models permits the development, validation and calibration of different lavatory concepts and configurations prior to any future full scale testing. The construction and testing of full scale models is expensive, and some of the costs can be defrayed through the use of virtual modeling. This project extends the work undertaken in the development of the draft specifications for the accessibility of next generation of passenger rail cars. The draft specifications increase the size of both the wheeled mobility devices and occupants as a reflection of the changes in population demographics, this has prompted the need to develop new accessible lavatories that are more inclusive for the user, and still meet the design constraints of the vehicle builders. The project uses the new recommended design parameters for wheeled mobility devices and the draft guidelines for new accessibility features. Current accessible lavatories that are used on VIA Rail cars in Canada, and the TALGO and the Acela in the US serve as base models for the 2-D and 3-D renderings. These designs are optimized, validated, and calibrated with mannequins that represent the 5th and 95th percentile populations on large wheeled mobility devices including; sport manual wheelchairs, power wheelchairs and 4 wheel scooters that meet the 30 inch wide by 54 inch long footprint. It is known that some accessible lavatories that on are on existing rolling stock do not meet the needs of all customers. This project will provide quantitative measures to evaluate current designs and recommend future designs that are more inclusive.

scholarly journals Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based ctDNA Assays: A Joint Consensus Recommendation of the BloodPAC’s Analytical Variables Working Group

2020 ◽  
Vol 66 (9) ◽  
pp. 1156-1166 ◽  
Author(s):  
James H Godsey ◽  
Angela Silvestro ◽  
J Carl Barrett ◽  
Kelli Bramlett ◽  
Darya Chudova ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Liquid Biopsy ◽  
Working Group ◽  
Circulating Tumor Dna ◽  
Next Generation ◽  
Analytical Validation ◽  
Consensus Recommendation ◽  
Next Generation Sequencing Ngs ◽  
Development And Validation ◽  
Generation Sequencing

Abstract Liquid biopsy, particularly the analysis of circulating tumor DNA (ctDNA), has demonstrated considerable promise for numerous clinical intended uses. Successful validation and commercialization of novel ctDNA tests have the potential to improve the outcomes of patients with cancer. The goal of the Blood Profiling Atlas Consortium (BloodPAC) is to accelerate the development and validation of liquid biopsy assays that will be introduced into the clinic. To accomplish this goal, the BloodPAC conducts research in the following areas: Data Collection and Analysis within the BloodPAC Data Commons; Preanalytical Variables; Analytical Variables; Patient Context Variables; and Reimbursement. In this document, the BloodPAC’s Analytical Variables Working Group (AV WG) attempts to define a set of generic analytical validation protocols tailored for ctDNA-based Next-Generation Sequencing (NGS) assays. Analytical validation of ctDNA assays poses several unique challenges that primarily arise from the fact that very few tumor-derived DNA molecules may be present in circulation relative to the amount of nontumor-derived cell-free DNA (cfDNA). These challenges include the exquisite level of sensitivity and specificity needed to detect ctDNA, the potential for false negatives in detecting these rare molecules, and the increased reliance on contrived samples to attain sufficient ctDNA for analytical validation. By addressing these unique challenges, the BloodPAC hopes to expedite sponsors’ presubmission discussions with the Food and Drug Administration (FDA) with the protocols presented herein. By sharing best practices with the broader community, this work may also save the time and capacity of FDA reviewers through increased efficiency.

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