Krokodil (Desomorphine)-induced osteonecrosis of the maxilla: a case report and literature review

Introduction: Desomorphine is an opioid formerly used to treat acute pain. It is simple to manufacture, which has recently led to an increase in its clandestine production under the name “Krokodil”. This article presents a case of oral problems related to its use first ever reported in France. Observation: A 36-year-old male patient presented with bone exposure in sector 1. He admitted to actively consuming “Krokodil IV” for several years. In the course of the clinical and radiological examinations, the patient was diagnosed with osteochemonecrosis of the maxillary induced by krokodil, considering that severe intrinsic and extrinsic adverse effects have been attributed to the drug. Discussion: A systematic literature review was conducted using articles from the Medline and Web of Science databases. To treat such a condition, two authors have described a process consisting of total excision of the necrotic tissue with 0.5 cm margins, combined with discontinuing the intake of the drug. However, these observations should be considered with caution because of the absence of any prospective studies. Conclusion: There are a number of etiologies for osteonecrosis in the context of radiotherapy, intake of bisphosphonates, and administration of bone resorption inhibitors. Unfortunately, in the case of krokodil, its high addictive nature makes it difficult for the patient to wean off the drug. Further, the heterogeneity of its manufacturing make it challenging to pharmacokinetically analyze its prolonged use. In view of the current literature, surgical therapy associated with weaning appears to be the most appropriate treatment, without being able to rule out addiction or necrotic relapses.

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Intestinal Myiasis Caused bySarcophagaspp. in Cusco, Peru: A Case Report and Review of the Literature

Case Reports in Infectious Diseases ◽

10.1155/2018/3685439 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Priscilla Ly ◽

Adiel Aizenberg ◽

Taylor Martin ◽

Martha Lopez ◽

Miguel Arturo Saldaña ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Intestinal Tract ◽

Strongyloides Stercoralis ◽

Necrotic Tissue ◽

Review Of The Literature ◽

Accidental Ingestion ◽

Morphological Examination ◽

Abdominal Symptoms ◽

Key Aspects

Myiasis is the infestation by dipterous fly larvae in humans and animals. The larvae can infect living or necrotic tissue involving the skin, nasopharynx, genitourinary, and gastrointestinal tracts. The accidental ingestion of eggs causes infection of the intestinal tract. We report a case of intestinal myiasis caused bySarcophagaspp. larvae in a two-year-old child from Limatambo province in the Cusco region of Peru. Live larvae were identified incidentally in this child’s stool sample during the study screening forStrongyloides stercoralis. The child did not have any constitutional or abdominal symptoms. The morphological examination of the specimen under magnification revealedSarcophagaspp. larvae. We performed a literature review of publications reporting intestinal myiasis caused bySarcophagaspp. and discussed key aspects of this infestation.

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Acute hypercalcemia and excessive bone resorption following anti-RANKL withdrawal: Case report and brief literature review

Bone ◽

10.1016/j.bone.2018.12.012 ◽

2019 ◽

Vol 120 ◽

pp. 482-486 ◽

Cited By ~ 8

Author(s):

Sophie Roux ◽

Marie-Hélène Massicotte ◽

Alexis Huot Daneault ◽

Lucie Brazeau-Lamontagne ◽

Jean Dufresne

Keyword(s):

Case Report ◽

Bone Resorption ◽

Literature Review ◽

Acute Hypercalcemia

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Solitary Endobronchial Papilloma with Malignant Transformation and Concomitant TB Infection: Case Report and Literature Review

Case Reports in Pulmonology ◽

10.1155/2017/1606432 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4

Author(s):

Mohammed Al Ghobain

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Literature Review ◽

Human Papilloma Virus ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Tumor Recurrence ◽

Posterior Segment ◽

Papilloma Virus ◽

Appropriate Treatment

We are reporting a case of solitary endobronchial papilloma located in posterior segment of the left upper lobe of the lung with malignant transformation and negative human papilloma virus (HPV) strains in a 40-year-old Saudi nonsmoker man. The patient had a concomitant tuberculosis (TB) infection. The patient received appropriate treatment in the form of anti-TB medication and surgical resection of the squamous cell carcinoma followed by chemotherapy. There was no evidence of tumor recurrence, resulting in a complete cure. We are reporting the case as well as a literature review related to the topic.

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Challenges encountered in the diagnosis of tuberculous otitis media: case report and literature review

The Journal of Laryngology & Otology ◽

10.1017/s0022215111000971 ◽

2011 ◽

Vol 125 (7) ◽

pp. 738-740 ◽

Cited By ~ 8

Author(s):

O T Dale ◽

A R Clarke ◽

A J Drysdale

Keyword(s):

Case Report ◽

Literature Review ◽

Otitis Media ◽

Rare Case ◽

Mycobacterial Infection ◽

Microbiological Diagnosis ◽

Suppurative Otitis Media ◽

Tuberculous Otitis Media ◽

The Uk ◽

Rule Out

AbstractObjective:To report a rare case of tuberculous otitis media, and to highlight barriers to clinical and microbiological diagnosis.Method:Case report and literature review.Results:Tuberculous otitis media is a rare cause of chronic ear infection in the UK. Its symptoms may mimic a range of other otological conditions, including otitis media, chronic suppurative otitis media, cholesteatoma and necrotising otitis media.Conclusion:This case report highlights the challenges of obtaining a clinical diagnosis of tuberculous otitis media, and emphasises the fact that screening for acid-fast bacilli is not sufficient, in isolation, to rule out mycobacterial infection.

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Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2019-0110 ◽

2019 ◽

Vol 32 (9) ◽

pp. 1039-1042 ◽

Cited By ~ 1

Author(s):

Anju Sukumaran

Keyword(s):

Case Report ◽

Literature Review ◽

Case Reports ◽

Case Presentation ◽

Appropriate Treatment ◽

Disease Case ◽

Prompt Diagnosis

Abstract Background Neurosarcoidosis is not a common entity from an endocrinology standpoint. Prompt diagnosis is essential in order to determine appropriate treatment and to establish prognosis. Case presentation Our case illustrates the difficulties encountered in making a diagnosis of sarcoidosis in an adolescent who presented with polyuria, polydipsia and hypernatremia. She developed panhypopituitarism and her deficits did not improve after treatment. Conclusion Pediatric endocrinologists diagnose and treat panhypopituitarism associated with many conditions. Neurosarcoidosis should be considered as part of the diagnosis in patients with panhypopituitarism, especially if there is evidence of multi organ disease. Case reports can effectively address the gap in knowledge due to the limited exposure of physicians to this field, especially in children.

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Conversion Disorder in a Pharmacogenomics, Polypharmacy Patient: Case Report

INNOVATIONS in pharmacy ◽

10.24926/iip.v12i4.4034 ◽

2021 ◽

Vol 12 (4) ◽

pp. 19

Author(s):

Michael J. Schuh ◽

Sheena Crosby

Keyword(s):

Case Report ◽

Psychiatric Disorder ◽

Patient Care ◽

Conversion Disorder ◽

Physical Medicine ◽

Patient Case ◽

Clinical Pharmacists ◽

Case Summary ◽

Appropriate Treatment ◽

Rule Out

Background: Conversion disorder (CD) is a relatively common psychiatric disorder likely encountered by clinical pharmacists but probably not easily identified by pharmacists. Case Summary: This is a patient case where a patient with a tremor was referred to the pharmacist led, polypharmacy, pharmacogenomics (PGx) service to rule out a PGx cause due to medication metabolism. No pharmacologic or PGx cause was found for the tremor which helped support and confirm a diagnosis of CD. Practice Implications: By working collaboratively with psychiatrists, neurologists, physical medicine colleagues, clinical pharmacists may add value to patient care by assisting with diagnoses and appropriate treatment.

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Postmeniscectomy osteonecrosis of the knee: A case report and literature review

Journal of Musculoskeletal Surgery and Research ◽

10.25259/jmsr_44_2021 ◽

2021 ◽

Vol 0 ◽

pp. 1-5

Author(s):

Abdulaziz Z Alomar

Keyword(s):

Case Report ◽

Middle East ◽

Early Diagnosis ◽

Literature Review ◽

Close Association ◽

Arab Countries ◽

Current Evidence ◽

Rare Form ◽

Spontaneous Osteonecrosis ◽

Appropriate Treatment

Postarthroscopic osteonecrosis of the knee (PAONK) is a rare form of osteonecrosis for which the pathogenesis and etiology remain poorly understood; however, there is evidence of a close association with meniscectomy in most PAONK cases. Based on this evidence, postmeniscectomy osteonecrosis of the knee (PMONK) has been suggested as a new category. As early diagnosis and appropriate treatment can improve prognosis, there is a need to differentiate PMONK from spontaneous osteonecrosis of the knee (SONK). This differentiation is specifically important in the Middle East and Arab countries where PMONK and PAONK have not been reported before, which could have resulted from under-reporting or under-diagnosis. To address this gap, we present a case of PMONK from this region and discuss assessment findings and treatment relative to the current evidence.

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Prolonged Coma after Pituitary Macro- adenoma Surgery: A Case Report with Short Literature review

Nepal Medical College Journal ◽

10.3126/nmcj.v21i3.26472 ◽

2019 ◽

Vol 21 (3) ◽

pp. 244-248

Author(s):

M. Karki ◽

A.J. Thapa ◽

Yam Bahadur Roka

Keyword(s):

Case Report ◽

Literature Review ◽

Pituitary Apoplexy ◽

Brain Mri ◽

Whole Body ◽

Total Excision ◽

Blurred Vision ◽

Tumor Patient ◽

Pterional Craniotomy ◽

Prolonged Coma

Prolonged coma after surgery of pituitary macro-adenoma with apoplexy, often previously unnoticed, is rare and not well reported complication. A 65 year male presented with complaints of headache and blurred vision since few months. Brain MRI was done and it reported macro- adenoma with pituitary apoplexy. Right pterional craniotomy was done following total excision of tumor. Patient developed whole body seizure at first day of surgery and went to prolonged coma.

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An unusual cause of postmenopausal bleeding: A case report

Z H Sikder Women’s Medical College Journal ◽

10.47648/zhswmcj.2020.v0201.08 ◽

2020 ◽

Vol 2 (Number 1) ◽

pp. 31-32

Author(s):

Sk. Zinnat Ara Nasreen ◽

Nusrat Mahjabeen

Keyword(s):

Case Report ◽

Postmenopausal Woman ◽

Literature Review ◽

Surgical Management ◽

Vaginal Bleeding ◽

Postmenopausal Bleeding ◽

History Of ◽

Rule Out

A 55year old postmenopausal woman presented to the gynaecology clinic with a 1week history of vaginal bleeding. She was investigated to rule out local and systemic causes including genital malignancy. The investigations were negative for genital malignancy and her symptoms settled with medical and surgical management. A short literature review of this unusual cause of postmenopausal bleeding is discussed here.

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