scholarly journals Facial fibromatosis: benign and aggressive, yet treatable!

2019 ◽  
Vol 25 (3) ◽  
pp. 29
Author(s):  
Gabriel Rodrigues ◽  
Devesh Sanjeev Ballal ◽  
Kantilatha Pai ◽  
Sunitha Carnelio ◽  
Vikas Singhal ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Needle Aspiration ◽  
Desmoid Tumors ◽  
Fine Needle ◽  
Facial Swelling ◽  
High Incidence ◽  
Neck Area ◽  
Subcutaneous Lipoma

Fibromatosis or desmoid tumors are locally aggressive neoplasms that have a propensity for local invasion and recurrence. The mainstay of treatment is excision with negative margins and the role of radiotherapy is controversial. Desmoids arising in the head and neck area are rare and pose a dilemma to the surgeon due to large number of vital structures that preclude resection with wide margins. This leads to a high incidence of recurrence. We present a case of a 24-year-old male who presented with an asymptomatic left sided facial swelling causing cosmetic deformity. A subcutaneous lipoma/fibroma/neuroma was suspected and a fine needle aspiration done was inconclusive. Computed tomography revealed a subcutaneous swelling that was excised. Histopathology revealed it to be a desmoid tumor. At the end of 4-year-follow-up, he has no local recurrence.

Role of fine needle aspiration cytology and computed tomography in the diagnosis of parotid swellings

1989 ◽  
Vol 76 (12) ◽  
pp. 1273-1274 ◽  
Author(s):  
E. R. T. C. Owen ◽  
A. K. Banerjee ◽  
A. J. N. Prichard ◽  
E. A. Hudson ◽  
A. E. Kark
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Granulomatous inflammation and organizing pneumonia: Role of computed tomography-guided lung fine needle aspirations, touch preparations and core biopsies in the evaluation of common non-neoplastic diagnoses

CytoJournal ◽  
2014 ◽  
Vol 11 ◽  
pp. 2 ◽  
Author(s):  
Anjali Saqi ◽  
Shana M. Coley ◽  
John P. Crapanzano
Keyword(s):  
Computed Tomography ◽  
Granulomatous Inflammation ◽  
Cytological Diagnosis ◽  
Type Ii ◽  
Organizing Pneumonia ◽  
Site Assessment ◽  
Fine Needle ◽  
Type Ii Pneumocytes

Background: Fine-needle aspirations (FNAs) and core biopsies (CBs), with or without touch preparations (TPs), are performed to characterize pulmonary lesions. Although a positive (P) or suspicious report is sufficient for further management, the significance of unsatisfactory (U), negative (N) and atypical (A) cytological diagnoses remains uncertain. The aims of the study were to correlate U, N and A cytological diagnoses with histological and/or clinical/radiological follow-up and evaluate the utility of FNAs, TPs and CBs. Materials and Methods: We performed a retrospective search and examined 30 consecutive computed tomography-guided transthoracic U, N and A lung FNAs (n = 23) and TPs (n = 7) with surgical pathology (SP) (n = 17) and/or clinical/radiological follow-up (n = 13) and compared them to 10 SP-confirmed P FNAs, which served as controls. Results: The 30 FNAs and TPs were from 29 patients. All 6 U specimens were scantly cellular. Granulomas, the most common specific benign cytological diagnosis, were evident in 8 (of 13) and 7 (of 11) N and A cytology cases, respectively. Histology corroborated the presence of granulomas identified on cytology. Organizing pneumonia was the second leading benign specific diagnosis (5/17), but it was rendered on histology (n = 5) and not FNAs or TPs. Evaluation of the A cases revealed that type II pneumocytes were the source of “atypical”, diagnoses often associated with granulomas or organizing pneumonia and lacked 3-D clusters evident in all P cases. Discussion: U, N and A FNAs and TPs lacked 3-D clusters seen in carcinomas and were negative on follow-up. Granulomas and organizing pneumonia were the most common specific benign diagnoses, but the latter was recognized on histology only. In the absence of a definitive FNA result at the time of on-site assessment, a CB with a TP containing type II pneumocytes increases the likelihood of a specific benign diagnosis.

The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation

2009 ◽  
Vol 62 (10) ◽  
pp. 931-934 ◽  
Author(s):  
C A P Wauters ◽  
B Kooistra ◽  
L J A Strobbe
Keyword(s):  
Ultrasound Guidance ◽  
Needle Aspiration ◽  
Processing Technique ◽  
Benign Lesions ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Malignant Lesions ◽  
The Difference

Aim:To compare breast fine needle aspiration (FNA) specimens prepared by conventional smearing (CS) versus monolayer preparation (MP), with respect to the conclusiveness of the cytopathological diagnosis.Methods:From 1992 to 1996, aspirators prepared aspirates themselves by direct smearing onto 2–4 slides. From 1999 to 2003, aspirate preparation was performed in the laboratory, creating a MP, using a Hettich cytocentrifuge. FNA diagnoses were categorised into inadequate (C1), benign (C2), atypical (C3), suspicious for malignancy (C4) and malignant (C5). The reference standard constituted histological follow-up. A conclusive FNA diagnosis was defined as C2 in lesions benign on follow-up and C5 in lesions malignant on histology.Results:From 1992 to 1996, 692 aspirates were processed by CS, whereas from 1999 to 2003, 1301 aspirates were processed by MP. More FNA were ultrasound-guided in the MP group (85.6% versus 21.5%, p<0.001). When compared with CS, MP-prepared FNA had conclusive diagnoses significantly more often (72.8% versus 58.5%, p<0.001). This effect remained significant when corrected for the difference in ultrasound guidance (adjusted odds ratio 1.7, 95% confidence interval 1.3 to 2.2, p<0.001), and was larger for malignant lesions than for benign lesions (51.7% versus 79.9%, p<0.001).Conclusion:Patients presenting with breast lesions can more often be offered a same-day, conclusive cytopathological diagnosis when FNA are prepared by a manual MP processing technique.

Evaluation of Indeterminate Thyroid Cytology by Second-Opinion Diagnosis or Repeat Fine-Needle Aspiration: Which Is the Best Approach?

2015 ◽  
Vol 59 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Rene Gerhard ◽  
Scott L. Boerner
Keyword(s):  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Definitive Diagnosis ◽  
Second Opinion ◽  
Fine Needle ◽  
Thyroid Cytology ◽  
Needle Aspiration Cytology ◽  
Thyroid Cytopathology

Objective: This study investigated a published series evaluating the role of second-opinion diagnosis (SOD) or repeat fine-needle aspiration cytology (RFNA) for indeterminate thyroid aspirates. Study Design: Twenty-three studies were selected and the following parameters were analyzed: disagreement between SOD or RFNA and the original diagnosis (OD), reclassification of OD according to the Bethesda system for reporting thyroid cytopathology, the rate of definitive diagnosis and the diagnostic performance of SOD and RFNA. Results: 7,154 thyroid FNAs were retrieved from 9 studies that investigated the role of SOD, including 1,048 (14.6%) cases originally reported as indeterminate. The 14 studies that analyzed the role of thyroid RFNA comprised 67,581 FNAs and included 7,246 (10.7%) indeterminate cases. A definitive diagnosis was achieved by SOD in 450 cases (42.9%) and RFNA in 1,645 cases (57.2%, p = 0.0001). Based on cases with histological follow-up, SOD demonstrated significantly higher rates of positive predictive value and accuracy than RFNA (55.8 vs. 37.7%, p = 0.0001; 67.4 vs. 56.0%, p = 0.0034, respectively). Conclusions: Both SOD and RFNA demonstrated an improvement in the diagnosis of initially indeterminate thyroid FNAs. RFNA achieved a definitive diagnosis for the majority of indeterminate cases. Regarding histological follow-up, SOD was shown to be more accurate than RFNA.

scholarly journals Cytologic features of primary monophasic synovial sarcoma of the thyroid gland

CytoJournal ◽  
2017 ◽  
Vol 14 ◽  
pp. 24 ◽  
Author(s):  
Chang-Soo Park ◽  
Young Kim ◽  
Eun-Hui Jeong ◽  
Nah-Ihm Kim ◽  
Yoo-Duk Choi
Keyword(s):  
Thyroid Gland ◽  
Synovial Sarcoma ◽  
Soft Tissue Tumor ◽  
Molecular Genetic ◽  
Needle Aspiration ◽  
Molecular Genetic Study ◽  
Fine Needle ◽  
The Past ◽  
Neck Area

Synovial sarcoma (SS) is a rare soft tissue tumor, commonly arising in para-articular areas of extremities, but can also present in the head and neck area. However, primary SS of the thyroid gland is an extremely rare tumor which has been reported only five times in previous English literatures. This report presents fine needle aspiration (FNA) cytology of primary monophasic SS of the thyroid gland. A 47-year- old woman incidentally detected thyroid nodule in the isthmus of right thyroid gland on an ultrasonography by regular health check-up. Because the possibility of malignancy could not be ruled out, FNA and surgical resection were performed. The cytological, histopathological, immunohistochemical, and molecular genetic study of SYT-SSX transcript were discussed. For the past 3 years of follow-up after surgery, no recurrence or metastasis has been identified.

scholarly journals Computed tomography-guided fine-needle aspiration biopsy

1997 ◽  
Vol 115 (1) ◽  
pp. 1343-1348
Author(s):  
Gilda da Cunha Santos ◽  
Sandra Regina Morini ◽  
Luzete Cristina Silva Granero ◽  
Rubens Chojniak ◽  
Adhemar Longatto Filho
Keyword(s):  
Computed Tomography ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Needle Aspiration ◽  
Histological Diagnosis ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Computed Tomography Guidance ◽  
Needle Aspiration Cytology

The therapeutic and prognostic evaluation of malignant neoplasias depends largely upon a precise morphologic diagnosis. Several papers have focused on the importance of fine-needle aspiration under computed tomography guidance in the diagnosis of unresectable neoplasms and in the investigation of metastases. The objective of this study is to evaluate the diagnostic accuracy, the sensitivity, and the negative predictive value obtained with the technique. Fine-needle aspiration cytology (FNAC) was performed on 207 patients, with a total of 210 cases, from 1991 to 1994, under computed tomography (CT) guidance. There were 128 (61.8 percent) males and 79 (38.2 percent) females with a mean age of 41 years (range 1 to 91 years). Lung and liver were the most frequent anatomic sites. The analysis of this material disclosed 41 cases with cytological diagnosis of negative for malignancy (19.52 percent), and in 131 (62.38 percent), the diagnosis was positive. It was possible to define the cytologic lineage in 54 percent of the cases. The diagnosis in 14 (6.67 percent) cases was suspicíous for malignancy, and in 24 (11.43 percent) cases the material was insufficient for the cytologic diagnosis. Of the 210 cases, 106 showed histological diagnosis and/ or clinical follow-up. Forty-seven (44.3 percent) had histological diagnosis before the FNAC and 50 cases (56.7 percent) histological diagnosis after the procedure. The comparison between cytological and histological diagnosis showed a sensibility of 80.4 percent, specificity of 100 percent, positive predictive value of 100 percent and negative of 16.7 percent. The efficiency of the test was 81.1 percent. This study showed that FNAC, under computed tomography guidance, is a sensitive and specific technique for the diagnosis of deep-seated lesions.

scholarly journals Tumor Neuroendokrin: Kasus Serial di RSUD Dr. Soetomo

2018 ◽  
Vol 2 (1) ◽  
pp. 28 ◽  
Author(s):  
Made Mahayasa ◽  
Paulus Soetamto Wibowo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Fine Needle Aspiration ◽  
Multislice Computed Tomography ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Resonance Imaging ◽  
Fine Needle

Latar belakang: tumor neuroendokrin (NETs) adalah neoplasma yang dapat mensekresi hormon dengan sindrom klinis yang bervariasi. Meskipun insidennya relatif rendah, NETs merupakan tantangan klinis karena presentasi klinis yang bervariasi dan tidak ada modalitas pencitraan awal yang dapat efektif. Kasus: didapatkan 5 kasus tumor neuroendokrin selama kurun waktu 2 tahun (2008-2010). Hampir sebagian besar pasien yaitu 80% mengeluh nyeri abdomen dan 1 orang pasien (20%) dengan keluhan sulit defekasi. Dari pemeriksaan pencitraan awal, ditunjukkan bahwa terdapat 2 subjek dengan asal tumor dari pankreas, 1 dari paraaorta kiri, 1 dari supra-renalis, dan 1 dari presakral. Pemeriksaan jaringan tumor melalui FNAB (fine needle aspiration biopsy) mengonfirmasi adanya Malignant Neuroendocrine Tumor pada semua pasien. Pada pemeriksaan penanda jaringan intraseluler semua menunjukkan peningkatan NSE yaitu berkisar dari 30,9-218,40 ng/ml. Dari penilaian resektabilitas tumor didapatkan 1 orang resektabel, 3 orang non-resektabel, dan 1 orang lagi menolak tindakan. Pada sebuah kasus dilakukan reseksi luas, yaitu tumor neuroendokrin pre-sakral yang sudah infiltrasi ke os sakrum (S3-4). Selama follow up paska operasi pasien ini didapatkan metastasis pada hepar dan meninggal 2 tahun kemudian. Simpulan: tumor neuroendokrin adalah bentuk neoplasma yang jarang dan muncul dengan berbagai variasi klinis. Penegakan diagnosis jaringan dapat dilakukan dengan FNAB guiding USG (ultrasonografi) atau CT dan pemeriksaan penanda jaringan NSE. Penentuan resektabilitas tumor dapat dilakukan dengan pemeriksaan CT, MSCT (multislice computed tomography) atau MRI (magnetic resonance imaging. Kesulitan dalam hal tindakan dan mortalitas yang tinggi disebabkan karena hampir sebagian besar pasien datang dalam keadaan tumor yang sudah lanjut.

Transthoracic Computed Tomography–Guided Lung Nodule Biopsy: Comparison of Core Needle and Fine Needle Aspiration Techniques

2016 ◽  
Vol 67 (3) ◽  
pp. 284-289 ◽  
Author(s):  
Bippan S. Sangha ◽  
Cameron J. Hague ◽  
Jennifer Jessup ◽  
Robert O'Connor ◽  
John R. Mayo
Keyword(s):  
Computed Tomography ◽  
Complication Rate ◽  
Chest Tube ◽  
Needle Biopsy ◽  
Pulmonary Hemorrhage ◽  
Needle Aspiration ◽  
Core Needle ◽  
Fine Needle ◽  
Diagnostic Samples

Purpose To determine if there is a statistically significant difference in the computed tomography (CT)–guided trans-thoracic needle biopsy diagnostic rate, complication rate, and degree of pathologist confidence in diagnosis between core needle biopsy (CNB) and fine needle aspiration biopsy (FNAB). Methods A retrospective cohort design was used to compare the diagnostic biopsy rate, diagnostic confidence, and biopsy-related complications of pneumothorax, chest tube placement, pulmonary hemorrhage, hemoptysis, admission to hospital, and length of stay between 251 transthoracic needle biopsies obtained via CNB (126) or FNAB (125). Complication rates were assessed using imaging and clinical follow-up. Final diagnosis was confirmed via surgical pathology or clinical follow-up over a period of up to 10 years. Results CNB provided diagnostic samples in 91% and FNA in 80% of biopsies, which was statistically significant ( P < .05). The sensitivities for CNB and FNAB were 89% (85 of 95) and 95% (84 of 88), respectively. The specificity of CNB was 100% (21 of 21) and for FNAB was 81% (2 of 11) with 2 false positives in the FNAB group. The differences in complication rate was not statistically significant for pneumothorax (50% vs 46%; determined by routine postbiopsy CT), chest tube (2% vs 4%), hemoptysis (4% vs 6%), and pulmonary hemorrhage (38% vs 47%) between FNAB and CNB, respectively. Seven patients requiring chest tube were admitted to hospital, 2 in the FNAB cohort for an average of 2.5 days and 5 in the CNB cohort for an average of 4.6 days. Conclusions CNB provided more diagnostic samples with no statistical difference in complication rate.

scholarly journals Identifying Contraindication to Resection in Patients with Pancreatic Carcinoma: The Role of Endoscopic Ultrasound

2002 ◽  
Vol 16 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Maurits J Wiersema
Keyword(s):  
Computed Tomography ◽  
Pancreatic Carcinoma ◽  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Imaging Modalities ◽  
Helical Computed Tomography ◽  
Dual Phase ◽  
Fine Needle

OBJECTIVE: To present recently published material comparing the performance of endosonography relative to other imaging modalities when evaluating the patient with a suspected or known pancreas carcinoma.METHODS: Medline was searched using the terms ‘endosonography’ and ‘pancreas neoplasms’. References from retrieved papers were reviewed to identify other reports. Emphasis was placed on peer-reviewed material published within the past three years that included comparison with other imaging modalities.RESULTS: Despite advances in cross-sectional imaging modalities, endosonography remains the most sensitive and specific method for identifying pancreatic mass lesions. The resectability of pancreatic carcinoma is best determined with dual-phase helical computed tomography, although endosonography may be slightly more accurate for lymph node assessment. Endoscopic ultrasound-guided fine needle aspiration biopsy has a high sensitivity (93%) and specificity (100%) when used in patients with masses in whom pancreatic cancer is suspected but prior biopsies have been negative.CONCLUSIONS: Endosonography helps in the diagnosis of pancreatic neoplasms through definitive inclusion or exclusion of a mass lesion as well as biopsy confirmation of malignancy. The role of endosonography in the determination of resectability has been eclipsed by dual-phase helical computed tomography. However, endoscopic ultrasound with fine needle aspiration of nonperitumoral lymph nodes may identify advanced disease with sufficient frequency to justify its routine use in patients with lesions that are thought to be resectable based on helical computed tomography.

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