Prevention of osteoporotic fractures in post-menopausal women

2000 ◽  
Vol 14 (2) ◽  
pp. 251-264 ◽  
Author(s):  
Juliet Compston
Keyword(s):  
Osteoporotic Fractures ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Relation between homocysteine and biochemical bone turnover markers and bone mineral density in peri- and post-menopausal women

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Markus Herrmann ◽  
Marius Kraenzlin ◽  
Gerhard Pape ◽  
Marga Sand-Hill ◽  
Wolfgang Herrmann
Keyword(s):  
Bone Mineral Density ◽  
Bone Resorption ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Venous Blood ◽  
Osteoporotic Fractures ◽  
Mineral Density ◽  
Menopausal Women ◽  
Hip Bmd ◽  
Post Menopausal

AbstractBackground: Recently, increased plasma homocysteine (Hcy) has been suggested as an independent risk factor for osteoporotic fractures. Therefore, it is tempting to speculate that Hcy adversely affects bone metabolism. This study aimed to analyze the relation between Hcy and biochemical markers of bone metabolism and bone mineral density (BMD). Materials and methods: We investigated 143 peri- and post-menopausal women [median age (25th–75th percentile), 67 (57–75) years]. All subjects underwent a detailed medical examination, measurement of bone mineral density at lumbar spine (BMD-LS) and total hip (BMD-HIP), and fasting venous blood and urine sampling. Osteocalcin (OC), serum calcium (Ca), urinary desoxypyridinoline cross-links (DPD), osteoprotegerin (OPG) and soluble receptor activator of NF-κB ligand (sRANKL) were studied. Results: According to BMD subjects were classified as normal (n=24), osteopenic (n=51) or osteoporotic (n=68). Median Hcy did not differ between normal, osteopenic and osteoporotic subjects (p=0.647). Partial correlation analysis, controlling for the major confounders, age, creatinine, menopause and previous fractures, revealed significant correlations between Hcy and DPD (r=0.193, p=0.022), as well as between Hcy and Ca (r=0.170, p=0.045). After adjustment for the same confounders, subsequent regression analysis confirmed significant associations of Hcy with DPD and Ca. No significant relations could be observed between Hcy and BMD-LS, BMD-HIP, OC, OPG or sRANKL. Conclusion: Our results demonstrate weak, but significant, relations between Hcy and markers of organic and inorganic bone resorption, suggesting a mechanistic role of Hcy in bone metabolism. The relation between Hcy and bone resorption was not dependent on OPG or sRANKL.

scholarly journals Etiology of Osteoporotic Fractures in Post-Menopausal Women

2015 ◽  
Vol 1 (2) ◽  
pp. 134
Author(s):  
Taeyong Lee ◽  
D. Anitha ◽  
Junghyun Park ◽  
Young-Seong Kim
Keyword(s):  
Osteoporotic Fractures ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Post-menopausal osteoporosis: prevalence of risk factors and probable symptoms

2018 ◽  
Vol 5 (12) ◽  
pp. 5253
Author(s):  
Manohar Bhatia ◽  
Ashok Mishra ◽  
Pradeep Sukla
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Lifestyle Modification ◽  
Osteoporotic Fractures ◽  
Modifiable Risk Factors ◽  
Average Life Expectancy ◽  
Milk Products ◽  
Post Menopausal Osteoporosis ◽  
Menopausal Women ◽  
Post Menopausal

Background: Osteoporosis jeopardizes the quality of life of many post-menopausal women due to its sequelae of fractures on trivial trauma. With a rapid increase in average life expectancy India is becoming home to a huge population at risk of osteoporosis. The aims and objectives of the study were to assess the prevalence of fractures due to trivial trauma and probable symptoms of osteoporosis and prevalence of modifiable and non-modifiable risk factors of osteoporosis in postmenopausal womenMethods: A cross-sectional study, conducted by a door to door survey in 400 post-menopausal women (below 65 yrs) in urban Gwalior city from September to December 2012. The risk factors of osteoporosis in post-menopausal women have been classified into modifiable and non-modifiable risk factors. Modifiable risk factors include exercise/physical activity and consuming milk and milk products while age of menarche, age of menopause, reproductive period and parity were categorized as non-modifiable risk factors.Results: In our study, the overall prevalence of osteoporotic symptoms was 62.75% (251/400). Out of 400 postmenopausal women, 45.25% had backache, 55.75% had joint pain and 24.00% had fractures. Prevalence of osteoporotic fractures was much higher (39.16%) in females not consuming milk and milk products & in females who never exercised (35.22%). 60% of females who underwent hysterectomy had osteoporotic fractures.Conclusions: The overall prevalence of osteoporotic fractures among post-menopausal females was higher in our study when compared to other studies in the same setting. Thus, a multipronged approach involving educational intervention, lifestyle modification and appropriate hormonal treatment is required. Lifestyle modification involves nutritional interventions and motivation for regular physical activity.

scholarly journals Denosumab for the Prevention of Osteoporotic Fractures in Post-Menopausal Women

2011 ◽  
Vol 29 (11) ◽  
pp. 951-961 ◽  
Author(s):  
Graham Scotland ◽  
Norman Waugh ◽  
Pamela Royle ◽  
Paul McNamee ◽  
Rob Henderson ◽  
...  
Keyword(s):  
Osteoporotic Fractures ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals POS1116 ENHANCING OSTEOPOROSIS MANAGEMENT: THE CONTRIBUTION OF FRAX® AND VFA IN TUNISIAN WOMEN

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 837.3-838
Author(s):  
C. Daldoul ◽  
N. El Amri ◽  
S. Laataoui ◽  
K. Baccouche ◽  
H. Zegaloui ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Fracture Risk ◽  
Osteoporotic Fractures ◽  
Interquartile Range ◽  
Therapeutic Decision ◽  
Major Osteoporotic Fractures ◽  
Menopausal Women ◽  
The Mean ◽  
The Difference ◽  
Post Menopausal

Background:The FRAX® is a tool proposed by the World Health Organization (WHO) to calculate 10-year fracture risk of hip fracture and major osteoporotic fractures. The utility of this tool is to help treatment decision when it is litigious. Previous low trauma fracture represent a factor in FRAX® calculation. However, asymptomatic osteoporotic vertebral fractures (VF) identified on X-rays or Vertebral Fracture Assessment (VFA) scans are rarely included. To the best of our knowledge, there was no previous evaluation of fracture risk in Tunisian women.Objectives:To compare hip fracture risk and major osteoporotic fractures risk using the FRAX® tool, without and with the consideration of asymptomatic VF on VFA. To evaluate the impact of FRAX® calculation and asymptomatic VF identified on VFA on osteoporosis management.Methods:We conducted a cross-sectional study over a period of 5 months at the rheumatology department. The study included post-menopausal women without a previous diagnosis of VF referred for BMD (Bone mineral density) measurement. Each participant had a BMD assessment and a VFA scan to detect VF. The FRAX® was calculated using femoral neck BMD initially without then with consideration of VF. The change of therapeutic decision was assessed after taking into consideration FRAX® and the VFA results.Results:The study included 210 post-menopausal women with a mean age of 61.5±8.5 years. The mean BMI was 31.04±5.52 kg/m2. One women was a current smoker and alcohol intake was not found in our sample. Thirty-seven percent of our participants had at least one fragility fracture. A severe fragility fracture was recorded in 10.5% and a previous hip fracture was reported in 5.24%. An early menopause was found in 19.5% of our women. Twenty percent of our population were receiving corticosteroids and 8.2% of our population had rheumatoid arthritis. The mean vertebral and total hip BMD was 0.955±0.165 g/cm2 and 0.850±0.135 g/cm2 respectively. Osteoporosis and low BMD were found in respectively 50% and 34.28%. The median probability of major osteoporotic fracture for our population was 1.5% with an interquartile range from 0.9 to 2.5% without using VFA data and 1.65% with an interquartile range from 1 to 2.6% while taking into consideration VFA results and the difference was statistically significant (p<0.0001). The median probability of hip fracture for our population was 0.4% with an interquartile range from 0.1 to 0.9% without using VFA data and 0.4% with an interquartile range from 0.1 to 1% while taking into consideration VFA results and the difference was statistically significant (p<0.0001). In all patients, the FRAX® was under the threshold intervention even after including the asymptomatic VF and it did not change the therapeutic decision. The presence of asymptomatic VF on VFA changed the therapeutic decision in 15% and indicated an anti-osteoporosis drug therapy.Conclusion:VFA scanning helped in the therapeutic decision in 15% of our population. In this evaluation, we showed that a comprehensive fracture risk pathway incorporating VFA has enhanced diagnosis of vertebral fractures and improved targeting of treatment better than FRAX® tool.Disclosure of Interests:None declared.

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