The management of retroperitoneal soft tissue sarcoma: a single institution experience with a review of the literature

2001 ◽  
Vol 27 (5) ◽  
pp. 491-497 ◽  
Author(s):  
A Pirayesh ◽  
Y Chee ◽  
T.R Helliwell ◽  
M.J Hershman ◽  
S.J Leinster ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Review Of The Literature ◽  
Single Institution ◽  
Retroperitoneal Soft Tissue Sarcoma

Aggressive Surgical Policies in a Retrospectively Reviewed Single-Institution Case Series of Retroperitoneal Soft Tissue Sarcoma Patients

2009 ◽  
Vol 27 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Alessandro Gronchi ◽  
Salvatore Lo Vullo ◽  
Marco Fiore ◽  
Chiara Mussi ◽  
Silvia Stacchiotti ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Sarcoma ◽  
Distant Metastases ◽  
Single Institution ◽  
En Bloc ◽  
Histologic Subtype ◽  
Retroperitoneal Soft Tissue Sarcoma

Purpose To explore whether the adoption of a systematic attempt to perform wider resections may lead to prognostic improvements in retroperitoneal soft tissue sarcoma (RSTS). Patients and Methods Two hundred eighty-eight consecutive patients who were surgically treated at a single referral center were analyzed. Because a shift toward a systematic, more aggressive surgical approach (ie, liberal en bloc resection of adjacent organs) was in place from 2002 onward, patients were divided in two groups accordingly. Overall survival, crude cumulative incidence (CCI) of local recurrence, and distant metastases were estimated. Univariable and multivariable analyses were carried out. Results Patients who underwent operation in the early period had a 5-year local recurrence rate of 48% compared with 28% for patients who were treated in the recent period. The number of distant metastases was greater in the recent group (22% v 13%), and overall survival was similar. In addition to the period of treatment, important independent determinants for local recurrence-free survival were histologic grade, histologic subtype, and radiation therapy. Overall, liposarcomas and grades 1 to 2 tumors had the greatest local benefit at 5 years. Conclusion In a single institution, the adoption of a policy of more liberal visceral en bloc resections was paralleled by greater local control. This benefit might translate into a prognostic improvement only on a longer follow-up for patients with a more indolent disease, whereas systemic failures seem to be the main problem in high-grade tumors. Radiation therapy could add some additional benefit to local outcome and possibly to survival.

Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution

2014 ◽  
Vol 22 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Jin Taek Park ◽  
Jong-Lyel Roh ◽  
Seon-Ok Kim ◽  
Kyung-Ja Cho ◽  
Seung-Ho Choi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Head And Neck ◽  
Single Institution ◽  
Oncological Outcomes

scholarly journals P-268 Surgical outcomes and strict follow-up of retroperitoneal soft-tissue sarcoma

2016 ◽  
Vol 27 ◽  
pp. ii77
Author(s):  
A. Chiappa ◽  
E. Bertani ◽  
A. Zbar ◽  
D. Foschi ◽  
F. Luca ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Surgical Outcomes ◽  
Retroperitoneal Soft Tissue Sarcoma

scholarly journals Soft-Tissue Sarcoma Mimicking Large Haematoma: A Report of Two Cases and Review of the Literature

2006 ◽  
Vol 14 (1) ◽  
pp. 90-95 ◽  
Author(s):  
R Niimi ◽  
A Matsumine ◽  
K Kusuzaki ◽  
A Okamura ◽  
T Matsubara ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Review Of The Literature

Influence of Prereferral Surgery in Soft Tissue Sarcoma: 10 Years’ Experience in a Single Institution

Orthopedics ◽  
2012 ◽  
Vol 35 (8) ◽  
pp. e1214-e1220 ◽  
Author(s):  
Maximilian Zacherl ◽  
Norbert Kastner ◽  
Matthias Glehr ◽  
Susanne Scheipl ◽  
Gerold Schwantzer ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Single Institution

scholarly journals Efficacy of combination-chemotherapy with pirarubicin, ifosfamide, and etoposide for soft tissue sarcoma: a single-institution retrospective analysis

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shiro Saito ◽  
Hisaki Aiba ◽  
Satoshi Yamada ◽  
Hideki Okamoto ◽  
Katsuhiro Hayashi ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Adverse Events ◽  
Combination Chemotherapy ◽  
Progressive Disease ◽  
Treatment Phase ◽  
Hematological Toxicity ◽  
Single Institution ◽  
Grade 3

Abstract Background The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy for patients with this disease. Methods Between 2008 and 2017, 25 patients with soft tissue sarcoma were treated with pirarubicin (30 mg/m2, 2 days), ifosfamide (2 g/m2, 5 days), and etoposide (100 mg/m2, 3 days) every 3 weeks. The primary endpoint was overall response, and the secondary endpoint was adverse events of this regimen. Results Responses to this regimen according to RECIST criteria were partial response (n = 9, 36%), stable disease (n = 9, 36%) and progressive disease (n = 7, 28%). During the treatment phase, frequent grade 3 or worse adverse events were hematological toxicities including white blood cell decreases (96%), febrile neutropenia (68%), anemia (68%), and platelet count decreases (48%). No long-term adverse events were reported during the study period. Conclusion This regimen was comparable to previously published doxorubicin-based combination chemotherapy in terms of response rate. Although there were no long-lasting adverse events, based on our results, severe hematological toxicity should be considered.

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