scholarly journals Concerning gender and therapy after acute myocardial infarction: are there differences between men and women?

2000 ◽  
Vol 21 (4) ◽  
pp. 261-262 ◽  
Author(s):  
J Alpert
2017 ◽  
Vol 120 (10) ◽  
pp. 1715-1719 ◽  
Author(s):  
Hilmi Alnsasra ◽  
Doron Zahger ◽  
Diklah Geva ◽  
Shlomi Matetzky ◽  
Roy Beigel ◽  
...  

Author(s):  
Lauren E Thompson ◽  
Frederick A Masoudi ◽  
Kensey L Gosch ◽  
Pamela N Peterson ◽  
Adam C Salisbury ◽  
...  

Background: Hemoglobin decline following acute myocardial infarction (AMI) is associated with long-term morbidity. Since women have lower baseline hemoglobin levels than men, whether the same absolute change in hemoglobin after AMI similarly affects outcomes in women and men is unknown. Methods: We examined patients discharged after AMI in the TRIUMPH registry between 2005 and 2008 who had admission and discharge hemoglobin levels. We compared the relationship between absolute change in hemoglobin during hospitalization with 6- and 12-month mortality and re-hospitalization by gender after adjusting for clinical variables including admission hemoglobin. Results: Of the 4,243 patients with AMI, 33% (1,400 of 4,243) were women. Women were older, had more co-morbidities, and were less likely to present with STEMI, or receive catheterization. Women had lower admission hemoglobin (12.9 g/dL ± 1.9 vs 14.5 ± 2.0, p= <0.01) and a smaller mean absolute change in hemoglobin during hospitalization (-1.5 g/dL ± 1.8 vs -1.6 ±1.8, p = 0.01) compared to men. The association between hemoglobin declines during hospitalization and mortality and re-hospitalization rates at 6 and 12-months were of a similar magnitude between men and women (all interaction p > 0.05). (Figure 1) Conclusion: Although women with AMI had lower admission hemoglobin values, similar declines in hemoglobin during hospitalization were associated with increases in mortality and re-hospitalization in women and men. These findings suggest that absolute change in hemoglobin is equally important at predicting outcomes in women and men, regardless of admission hemoglobin levels.


2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
S.H. Hosseini Dehkordi ◽  
F. Gholitabar ◽  
A. Lemor ◽  
S. Lee ◽  
S. Ahsan ◽  
...  

2000 ◽  
Vol 85 (12) ◽  
pp. 1486-1489 ◽  
Author(s):  
Viola Vaccarino ◽  
Lori Parsons ◽  
Nathan R. Every ◽  
Hal V. Barron ◽  
Harlan M. Krumholz

2001 ◽  
Vol 38 (3) ◽  
pp. 729-735 ◽  
Author(s):  
Kate MacIntyre ◽  
Simon Stewart ◽  
Simon Capewell ◽  
James W.T Chalmers ◽  
Jill P Pell ◽  
...  

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e022782 ◽  
Author(s):  
Mouaz Alsawas ◽  
Zhen Wang ◽  
M Hassan Murad ◽  
Mohammed Yousufuddin

ObjectiveTo assess gender disparity in outcomes among hospitalised patients with acute myocardial infarction (AMI), acute decompensated heart failure (ADHF) or pneumonia.DesignA retrospective cohort study.SettingA tertiary referral centre in Midwest, USA.ParticipantsWe evaluated 12 265 adult patients hospitalised with ADHF, 15 777 with AMI and 12 929 with pneumonia, from 1 January 1995 through 31 August 2015. Patients were selected using International Classification of Diseases, Ninth Revision, Clinical Modification codes.Primary and secondary outcome measuresPrevalence of comorbidities, 30-day mortality and 30-day readmission. Comorbidities were chosen from the 20 chronic conditions, specified by the Office of the Assistant Secretary for Health. Logistic regression analysis was conducted adjusting for multiple confounders.ResultsPrevalence of comorbidities was significantly different between men and women in all three conditions. After adjusting for age, length of stay, multicomorbidities and residence, there was no significant difference in 30-day mortality between men and women in AMI or ADHF, but men with pneumonia had slightly higher 30-day mortality with an OR of 1.19 (95% CI 1.06 to 1.34). There was no significant difference in 30-day readmission between men and women with AMI or pneumonia, but women with ADHF were slightly more likely to be readmitted within 30 days with OR 0.90 (95% CI 0.82 to 0.99).ConclusionGender differences in the distribution of comorbidities exist in patients hospitalised with AMI, ADHF and pneumonia. However, there is minimal clinically meaningful impact of these differences on outcomes. Efforts to address gender difference may need to be diverted towards targeting overall population health, reducing race/ethnicity disparity and improving access to care.


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