Urine Albumin-Creatinine Ratio Versus Albumin Excretion for Albuminuria Staging: A Prospective Longitudinal Cohort Study

2016 ◽  
Vol 67 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Priya Vart ◽  
Lieneke Scheven ◽  
Hiddo J. Lambers Heerspink ◽  
Paul E. de Jong ◽  
Dick de Zeeuw ◽  
...  
Keyword(s):  
Cohort Study ◽  
Longitudinal Cohort Study ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Albumin Excretion ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio ◽  
Prospective Longitudinal ◽  
Ratio Versus ◽  
Prospective Longitudinal Cohort

scholarly journals Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes

2018 ◽  
Vol 56 (1) ◽  
pp. 155-162 ◽  
Author(s):  
Gautam Das ◽  
Peter N Taylor ◽  
Hussam Abusahmin ◽  
Amer Ali ◽  
Brian P Tennant ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin Excretion ◽  
Albumin Excretion ◽  
Urine Albumin ◽  
The Metabolic Syndrome ◽  
Patients With Diabetes ◽  
Urine Albumin Creatinine Ratio ◽  
Serum Tsh

Background Microalbuminuria represents vascular and endothelial dysfunction. Thyroid hormones can influence urine albumin excretion as it exerts crucial effects on the kidney and on the vascular system. This study explores the relationship between serum thyrotropin and urine albumin excretion in euthyroid patients with diabetes. Methods A total of 433 patients with type 1 or 2 diabetes were included in this retrospective cross-sectional study. Data included anthropometric measurements and biochemical parameters from diabetes clinic. Males with urine albumin creatinine ratio >2.5 and female’s >3.5 mg/mmoL were considered to have microalbuminuria. Results 34.9% of the patients had microalbuminuria. Prevalence of microalbuminuria increased according to TSH quartiles (26.9, 34.6, 38.5 and 44.9%, P for trend = 0.02). In a fully adjusted logistic regression model, higher TSH concentrations were associated with high prevalence of microalbuminuria (adjusted odds ratio 2.06 [95% CI: 1.14–3.72]; P = 0.02), while comparing the highest with the lowest quartile of TSH. Multiple linear regression analysis showed an independent association between serum TSH and urine albumin creatinine ratio (β = 0.007, t = 2.03 and P = 0.04). The risk of having microalbuminuria was higher with rise in TSH concentration in patients with younger age (<65 years), raised body mass index (≥25 kg/m2), hypertension, type 2 diabetes and hyperlipidaemia and age was the most important determinant ( P for interaction = 0.02). Conclusion Serum TSH even in the euthyroid range was positively associated with microalbuminuria in euthyroid patients with diabetes independent of traditional risk factors. This relationship was strongest in patients with components of the metabolic syndrome.

scholarly journals Urine Albumin/Creatinine Ratio and Microvascular Disease in Elderly Hypertensive Patients without Comorbidities

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Guihua Jian ◽  
Wenjun Lin ◽  
Niansong Wang ◽  
Junnan Wu ◽  
Xianfeng Wu
Keyword(s):  
Cohort Study ◽  
Essential Hypertension ◽  
Microvascular Disease ◽  
Creatinine Ratio ◽  
Elderly Male ◽  
Albumin Creatinine Ratio ◽  
Hypertensive Patients ◽  
Female Patients ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio

Objectives. A high urine albumin/creatinine ratio (UACR) is associated with microvascular disease in hypertensive patients. However, hypertensive patients frequently have other comorbidities. Thus, it is difficult to distinguish the role of UACR from that of comorbidities in microvascular disease. The aim of this study was to evaluate the association between UACR and microvascular disease in elderly hypertension patients without comorbidities. Methods. A cross-sectional cohort study of 2252 essential hypertension patients aged 65-94 years without comorbidities between January 1, 2016, and December 31, 2017, was conducted. Microvascular disease was evaluated by hypertension retinopathy (HR). Multivariable adjusted odds of HR by UACR quartiles were determined using logistic regression. Results. The HR prevalence was 22.1% ( n = 472 ) among the cohort study and was significantly different among UACR quartiles (19.7%, 20.3%, 22.0%, and 26.4% in quartiles 1, 2, 3, and 4, respectively, P = 0.036 ). After adjustment for covariates, higher UACR ( odds   ratio   OR = 1.42 , 95% confidence interval (CI) 1.05-1.92, quartile 4 versus 1) were significantly associated with HR. Among male patients, higher UACR ( OR = 1.65 , 95% CI 1.07-2.55, quartile 4 versus 1) were significantly associated with HR after adjustment for covariates. Among female patients, however, 64% and 40% increased odds of HR were noted in the highest and lowest UACR (quartiles 4 and 1, respectively) compared to UACR quartile 2. Conclusions. Microvascular disease was associated with higher UACR in elderly male essential hypertension patients without comorbidities but was associated with lower and higher UACR in female patients without comorbidities.

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