scholarly journals Urine Albumin/Creatinine Ratio and Microvascular Disease in Elderly Hypertensive Patients without Comorbidities

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Guihua Jian ◽  
Wenjun Lin ◽  
Niansong Wang ◽  
Junnan Wu ◽  
Xianfeng Wu
Keyword(s):  
Cohort Study ◽  
Essential Hypertension ◽  
Microvascular Disease ◽  
Creatinine Ratio ◽  
Elderly Male ◽  
Albumin Creatinine Ratio ◽  
Hypertensive Patients ◽  
Female Patients ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio

Objectives. A high urine albumin/creatinine ratio (UACR) is associated with microvascular disease in hypertensive patients. However, hypertensive patients frequently have other comorbidities. Thus, it is difficult to distinguish the role of UACR from that of comorbidities in microvascular disease. The aim of this study was to evaluate the association between UACR and microvascular disease in elderly hypertension patients without comorbidities. Methods. A cross-sectional cohort study of 2252 essential hypertension patients aged 65-94 years without comorbidities between January 1, 2016, and December 31, 2017, was conducted. Microvascular disease was evaluated by hypertension retinopathy (HR). Multivariable adjusted odds of HR by UACR quartiles were determined using logistic regression. Results. The HR prevalence was 22.1% ( n = 472 ) among the cohort study and was significantly different among UACR quartiles (19.7%, 20.3%, 22.0%, and 26.4% in quartiles 1, 2, 3, and 4, respectively, P = 0.036 ). After adjustment for covariates, higher UACR ( odds   ratio   OR = 1.42 , 95% confidence interval (CI) 1.05-1.92, quartile 4 versus 1) were significantly associated with HR. Among male patients, higher UACR ( OR = 1.65 , 95% CI 1.07-2.55, quartile 4 versus 1) were significantly associated with HR after adjustment for covariates. Among female patients, however, 64% and 40% increased odds of HR were noted in the highest and lowest UACR (quartiles 4 and 1, respectively) compared to UACR quartile 2. Conclusions. Microvascular disease was associated with higher UACR in elderly male essential hypertension patients without comorbidities but was associated with lower and higher UACR in female patients without comorbidities.

Effect of Cilnidipine on Normal to Marginally Elevated Urine Albumin-Creatinine Ratio in Asymptomatic Non-Diabetic Hypertensive Patients

2010 ◽  
Vol 30 (10) ◽  
pp. 699-706 ◽  
Author(s):  
Takaaki Nakatsu ◽  
Shinji Toyonaga ◽  
Keiichi Mashima ◽  
Yoko Yuki ◽  
Aya Nishitani ◽  
...  
Keyword(s):  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Hypertensive Patients ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio

scholarly journals Comparison of urine albumin creatinine ratio with the pediatric index of mortality 2 score for prediction of pediatric intensive care unit outcomes

2021 ◽  
Author(s):  
Shifa Nismath ◽  
Suchetha S. Rao ◽  
B. S. Baliga ◽  
Vaman Kulkarni ◽  
Gayatri M. Rao
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Characteristic Curve ◽  
Pediatric Intensive Care ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Urine Albumin Creatinine Ratio ◽  
Pediatric Index Of Mortality

Abstract Background Predicting morbidity and mortality in a pediatric intensive care unit (PICU) is of extreme importance to make precise decisions for better outcomes. Aim We compared the urine albumin creatinine ratio (ACR) with the established PICU score, pediatric index of mortality 2 (PIM 2) for predicting PICU outcomes. Methods This cross-sectional study enrolled 67 patients admitted to PICU with systemic inflammatory response syndrome. Urine ACR was estimated on admission, and PIM 2 score was calculated. ACR was compared with PIM 2 for PICU outcome measures: the need for inotropes, development of multiple organ dysfunction syndrome (MODS), duration of PICU stay, and survival. Results Microalbuminuria was found in 77.6% of patients with a median ACR of 80 mg/g. ACR showed a significant association with the need for inotropes (p < 0.001), MODS (p = 0.001), and significant correlation to PICU stay (p 0.001, rho = 0.361). The area under the receiver operating characteristic curve for ACR (0.798) was comparable to that of PIM 2 (0.896). The cutoff value of ACR derived to predict mortality was 110 mg/g. The study subjects were divided into 2 groups: below cutoff and above the cutoff. Outcome variables, inotrope use, MODS, mortality, and PICU stay compared between these subgroups, were statistically significant. Conclusion ACR is a good predictor of PICU outcomes and is comparable to PIM 2 for mortality prediction.

scholarly journals Relationship between serum thyrotropin and urine albumin excretion in euthyroid subjects with diabetes

2018 ◽  
Vol 56 (1) ◽  
pp. 155-162 ◽  
Author(s):  
Gautam Das ◽  
Peter N Taylor ◽  
Hussam Abusahmin ◽  
Amer Ali ◽  
Brian P Tennant ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin Excretion ◽  
Albumin Excretion ◽  
Urine Albumin ◽  
The Metabolic Syndrome ◽  
Patients With Diabetes ◽  
Urine Albumin Creatinine Ratio ◽  
Serum Tsh

Background Microalbuminuria represents vascular and endothelial dysfunction. Thyroid hormones can influence urine albumin excretion as it exerts crucial effects on the kidney and on the vascular system. This study explores the relationship between serum thyrotropin and urine albumin excretion in euthyroid patients with diabetes. Methods A total of 433 patients with type 1 or 2 diabetes were included in this retrospective cross-sectional study. Data included anthropometric measurements and biochemical parameters from diabetes clinic. Males with urine albumin creatinine ratio >2.5 and female’s >3.5 mg/mmoL were considered to have microalbuminuria. Results 34.9% of the patients had microalbuminuria. Prevalence of microalbuminuria increased according to TSH quartiles (26.9, 34.6, 38.5 and 44.9%, P for trend = 0.02). In a fully adjusted logistic regression model, higher TSH concentrations were associated with high prevalence of microalbuminuria (adjusted odds ratio 2.06 [95% CI: 1.14–3.72]; P = 0.02), while comparing the highest with the lowest quartile of TSH. Multiple linear regression analysis showed an independent association between serum TSH and urine albumin creatinine ratio (β = 0.007, t = 2.03 and P = 0.04). The risk of having microalbuminuria was higher with rise in TSH concentration in patients with younger age (<65 years), raised body mass index (≥25 kg/m2), hypertension, type 2 diabetes and hyperlipidaemia and age was the most important determinant ( P for interaction = 0.02). Conclusion Serum TSH even in the euthyroid range was positively associated with microalbuminuria in euthyroid patients with diabetes independent of traditional risk factors. This relationship was strongest in patients with components of the metabolic syndrome.

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