scholarly journals Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney

2017 ◽  
Vol 70 (3) ◽  
pp. 406-414 ◽  
Author(s):  
Meredith C. Foster ◽  
Andrew S. Levey ◽  
Lesley A. Inker ◽  
Tariq Shafi ◽  
Li Fan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Serum Protein ◽  
The Elderly ◽  
Low Molecular Weight

scholarly journals Effect of ageing on plasma lipoprotein(a) levels

2002 ◽  
Vol 39 (3) ◽  
pp. 237-240 ◽  
Author(s):  
Harukuni Akita ◽  
Miyao Matsubara ◽  
Hitoshi Shibuya ◽  
Hirotoshi Fuda ◽  
Hitoshi Chiba
Keyword(s):  
Molecular Weight ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
The Elderly ◽  
Low Molecular Weight ◽  
Lipoprotein A ◽  
Significant Difference ◽  
The Mean ◽  
Japanese Subjects

Background Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerosis and increases with age. The purpose of this study was to determine the effect of ageing on Lp(a) for three different apo(a) phenotypes. Methods We measured plasma Lp(a) concentrations in 551 unrelated Japanese subjects (20-88 years of age). We performed statistical analyses separately for three apo(a) phenotypes: the low-molecular-weight (LMW) phenotype with the F, B or S1 isoform, the intermediate-molecular-weight (IMW) phenotype with the S2 isoform and the high-molecular-weight (HMW) phenotype with the S3 or S4 isoform. Results For each phenotype, the mean plasma Lp(a) concentration and the frequency of Lp(a) concentrations ≥ 250 mg/L increased with age. Further, a statistically significant difference was always found between the younger subjects (20-39 years of age) and the elderly (over 60 years). The frequency of coronary heart disease increased with age, particularly for the LMW and IMW phenotypes. Conclusions We conclude that ageing elevates plasma Lp(a) concentrations, which may have a role in the prevalence of coronary heart disease in the elderly, especially those with the LMW or IMW phenotypes.

Low molecular weight heparin and fatal spontaneous extraperitoneal hematoma in the elderly

2011 ◽  
Vol 12 (1) ◽  
pp. 172-174 ◽  
Author(s):  
Federica Pace ◽  
Giovanni M. Colombo ◽  
Lucia R. Del Vecchio ◽  
Andrea Tavanti ◽  
Giancarlo Aguglia ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
The Elderly ◽  
Low Molecular Weight

scholarly journals Safety and Efficacy of Low Molecular Weight Heparin for Thromboprophylaxis in the Elderly: A Network Meta-Analysis of Randomized Clinical Trials

2021 ◽  
Vol 12 ◽  
Author(s):  
Hui-qin Yang ◽  
Man-cang Liu ◽  
Wen-jun Yin ◽  
Ling-yun Zhou ◽  
Xiao-cong Zuo
Keyword(s):  
Molecular Weight ◽  
High Risk ◽  
Low Molecular Weight Heparin ◽  
Meta Analysis ◽  
The Elderly ◽  
Cumulative Probability ◽  
Low Molecular Weight ◽  
Efficacy And Safety ◽  
Safety And Efficacy ◽  
Safety Outcomes

Background: Given their changing pathophysiology, elderly patients carry a high risk of embolism and bleeding events; hence, use of appropriate anticoagulants is very important. Low molecular weight heparin (LMWH) is one of the most widely used anticoagulants although LMWHs differ in their anti-Xa, antithrombin, and anticoagulant activities. To date, no study has directly compared the safety and efficacy of different LMWHs in the elderly. We aimed to compare such differences by conducting a network meta-analysis.Methods: We searched the Pubmed, Embase, and Cochrane databases for randomized controlled trials (RCTs) of LMWHs that included patients ≥60 years old up to July 22, 2020. Safety outcomes included venous thromboembolism (VTE) or VTE-related death, deep thrombus embolism, and pulmonary embolism. Safety outcomes were clinically relevant bleeding, major bleeding, minor bleeding, and all-cause death. We calculated relative ratios (RR) and 95% confidence intervals (CI) for all outcomes. The cumulative ranking probabilities (SUCRA) were conducted to rank the comparative effects and safety of all LMWHs.Results: We included 27 RCTs (30,441 elderly), comprising five LMWHs. LMWH was more effective than placebo in preventing VTE or VTE-related death (RR 0.36, 95% CI 0.25–0.53) but less effective than a novel oral anticoagulant (RR 1.59, 95% CI 1.33–1.91) and safer than acenocoumarol regarding risk of clinically relevant bleeding (RR 0.67, 95% CI 0.49–0.90). However, indirect comparison of efficacy and safety of the five LMWHs showed no significant difference in our network analysis, and the subgroup analyses (such as in patients with deep venous thrombosis, cardiac disease, or age >65 years old) supported the results. The SUCRA showed that tinzaparin performed best in preventing VTE or VTE-related death (SUCRA 68.8%, cumulative probability 42.3%) and all-cause death (SUCRA 84.2%, cumulative probability 40.7%), whereas nadroparin was predominant in decreasing the risk of clinically relevant bleeding (SUCRA 84.8%, cumulative probability 77.0%).Conclusions: On present evidence, there are no significant differences in the efficacy and safety of different LMWHs for the elderly. According to the rank probability analysis, nadroparin seems to be safer for the elderly with a high risk of bleeding, whereas tinzaparin is more effective for those with low bleeding risk.

scholarly journals Role of Early Low-Molecular-Weight Heparin Prophylaxis in the Surgical Treatment of Degenerative Spinal Diseases in the Elderly Patients

2016 ◽  
Vol 07 (09) ◽  
pp. 375-380
Author(s):  
Carlo Doria ◽  
Gianfilippo Caggiari ◽  
Giulia Raffaella Mosele ◽  
Leonardo Puddu ◽  
Paolo Tranquilli Leali
Keyword(s):  
Molecular Weight ◽  
Surgical Treatment ◽  
Elderly Patients ◽  
Low Molecular Weight Heparin ◽  
The Elderly ◽  
Low Molecular Weight ◽  
Spinal Diseases ◽  
Heparin Prophylaxis

scholarly journals Low molecular weight heparin improves healing of chronic venous ulcers especially in the elderly

2013 ◽  
Vol 12 (2) ◽  
pp. 150-153 ◽  
Author(s):  
Raffaele Serra ◽  
Gianluca Buffone ◽  
Vincenzo Molinari ◽  
Rossella Montemurro ◽  
Paolo Perri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
The Elderly ◽  
Low Molecular Weight ◽  
Venous Ulcers

Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes

2001 ◽  
Vol 38 (2) ◽  
pp. 120-123 ◽  
Author(s):  
Miyao Matsubara ◽  
Harukuni Akita ◽  
Hitoshi Shibuya ◽  
Hitoshi Chiba
Keyword(s):  
Molecular Weight ◽  
The Elderly ◽  
High Plasma ◽  
Low Molecular Weight ◽  
Exact Probability ◽  
Japanese Men ◽  
Established Risk Factor ◽  
Apolipoprotein A ◽  
Old Men ◽  
Japanese Subjects

Lipoprotein(a) [Lp(a)] is an established risk factor for atherosclerosis. High plasma Lp(a) concentrations are associated with low-molecular-weight (LMW) apolipoprotein(a) (apo a) phenotypes, which raises the question of whether LMW apo a phenotypes occur less frequently in the elderly. To assess this possibility, we studied apo A phenotype and allele frequencies in Japanese subjects ≥80 years old (men:women=40:34) in comparison with those <80 years old (men:women= 221:296). Significantly fewer LMW phenotypes and LMW alleles were observed in ≥80 year old men compared with those <80 years old: 2·5% versus 16·1% for the LMW phenotype frequency and 1·3% versus 9·7% for the LMW allele frequency ( P<0·05, Fisher's exact probability test). Similar differences were not found in the women. Consistent with this, plasma Lp(a) concentrations were significantly lower in the men ≥80 years old than in the younger group. These results indicate that LMW apo a phenotypes are associated with a shorter lifespan in men but not in women, possibly reflecting the higher susceptibility of men to atherosclerosis.

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