scholarly journals Antifibrotic Agents for the Management of CKD: A Review

2022 ◽  
Author(s):  
Marta Ruiz-Ortega ◽  
Santiago Lamas ◽  
Alberto Ortiz
Keyword(s):  
Antifibrotic Agents

scholarly journals Renin Inhibition Reverses Renal Disease in Transgenic Mice by Shifting the Balance Between Profibrotic and Antifibrotic Agents

Hypertension ◽  
2013 ◽  
Vol 61 (4) ◽  
pp. 901-907 ◽  
Author(s):  
Panagiotis Kavvadas ◽  
Lise Weis ◽  
Ahmed B. Abed ◽  
David L. Feldman ◽  
Jean-Claude Dussaule ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Renal Disease ◽  
Renin Inhibition ◽  
Antifibrotic Agents

Risk of Hypotony After Primary Trabeculectomy With Antifibrotic Agents in a Black West African Population

1998 ◽  
Vol 7 (2) ◽  
pp. 82???85 ◽  
Author(s):  
Kuldev Singh ◽  
Sally Byrd ◽  
Peter R. Egbert ◽  
Donald Budenz
Keyword(s):  
West African ◽  
African Population ◽  
Antifibrotic Agents

scholarly journals Effects of antifibrotic agents on TGF-β1, CTGF and IFN-γ expression in patients with idiopathic pulmonary fibrosis

2007 ◽  
Vol 101 (8) ◽  
pp. 1821-1829 ◽  
Author(s):  
Eleni G. Tzortzaki ◽  
Katerina M. Antoniou ◽  
Maria I. Zervou ◽  
Irini Lambiri ◽  
Anastassios Koutsopoulos ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Ifn Γ ◽  
Antifibrotic Agents ◽  
Tgf Β1

Noncorneal Complications

2013 ◽  
Author(s):  
Anurag Shrivastava ◽  
Kuldev Singh
Keyword(s):  
Careful Attention ◽  
Filtration Surgery ◽  
Antifibrotic Therapy ◽  
Increased Risk ◽  
Bleb Leak ◽  
Antifibrotic Agents ◽  
Thin Walled ◽  
Careful Manipulation

Most glaucoma specialists advocate the use of 5-fluorouracil (5-FU) and mitomycin-C (MMC) in various concentrations during the intraoperative and postoperative periods to help inhibit postoperative scarring, the primary cause of filtration surgery failure. Although the increased use of antifibrotic agents as adjunctive therapy to guarded filtration surgery has improved the likelihood of operative success, there are many additional complications associated with this class of medications. It is the nature of filtration surgery as it is performed today that successful drainage of aqueous comes with a price. Any adjunct that improves the intraocular pressure (IOP)-lowering success of surgery must be assessed in light of this increased risk. A leaking bleb is one of the most common complications seen after trabeculectomy and may occur at any point postoperatively. This complication has been reported with an incidence ranging between 17% and 42% according to one review. More recent estimates have been somewhat lower, at between 8% and 14.6%. The longer the postoperative follow-up, the greater the cumulative likelihood of bleb leakage. It is imperative that the bleb be checked periodically for leaks, primarily through examination and standard Seidel testing. Use of antifibrotic therapy is associated with increased formation of thin-walled cystic blebs, which are more likely to result in both short-term and long-term complications. The timing of a bleb leak will dictate management. Many early postoperative bleb leaks resolve without intervention but can significantly decrease the likelihood of trabeculectomy success. Early postoperative bleb leaks are often attributed to surgical technique and can generally be avoided by use of appropriate blunt instruments and careful attention to surgical detail. The simple use of nontoothed forceps when handling the conjunctiva can prevent small buttonhole conjunctival tears, which often result in early postoperative bleb leaks. However, even with careful manipulation, friable conjunctival tissue can be prone to small tears. While some have advocated the use of light cautery, or even tissue adhesives to close bleb leaks, the use of such techniques has diminished in the antifibrotic era. Intraoperative suturing of buttonholes is definitive.

scholarly journals Acute exacerbation of chronic fibrosing interstitial pneumonia in patients receiving antifibrotic agents: incidence and risk factors from real-world experience

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kodai Kawamura ◽  
Kazuya Ichikado ◽  
Hidenori Ichiyasu ◽  
Keisuke Anan ◽  
Yuko Yasuda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Exacerbation ◽  
Interstitial Pneumonia ◽  
Real World ◽  
Antifibrotic Agents

Development of hepatic fibrosis (cirrhosis) model in rats and screening of the antifibrotic agents

1998 ◽  
Vol 95 ◽  
pp. 165
Author(s):  
Y.S. Lee ◽  
K.Y. Kim ◽  
B.S. Yu ◽  
K.S. Kil ◽  
J.Y. Jeong ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Antifibrotic Agents

Screening for inhibitors of the MMP-2/-9 — Collagen interaction as antifibrotic agents by surface plasmon resonance

2003 ◽  
Vol 38 ◽  
pp. 85
Author(s):  
A. Schuster ◽  
M. Ruehl ◽  
R. Farndale ◽  
G. Knight ◽  
M. Seja ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Antifibrotic Agents
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