Proteomic Analysis of Chronic Pancreatitis and Pancreatic Adenocarcinoma

2005 ◽  
Vol 129 (5) ◽  
pp. 1454-1463 ◽  
Author(s):  
Tatjana Crnogorac–Jurcevic ◽  
Rathi Gangeswaran ◽  
Vipul Bhakta ◽  
Gabriele Capurso ◽  
Samuel Lattimore ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Adenocarcinoma ◽  
Proteomic Analysis

MTHFR C677T polymorphism in chronic pancreatitis and pancreatic adenocarcinoma

2008 ◽  
Vol 26 (6) ◽  
pp. 659-663 ◽  
Author(s):  
Ivan Nisevic ◽  
Jelena Dinic ◽  
Aleksandra Nikolic ◽  
Valentina Djordjevic ◽  
Snezana Lukic ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Adenocarcinoma ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

Diagnostic criteria of pancreatic pathology.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16696-e16696
Author(s):  
Irina V. Neskubina ◽  
Elena M. Frantsiyants ◽  
Irina V. Kaplieva ◽  
Ekaterina I. Surikova ◽  
Valeria A. Bandovkina ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Pancreatic Adenocarcinoma ◽  
Neuroendocrine Tumors ◽  
Malignant Tumors ◽  
Lymphatic Vessels ◽  
Blood Levels ◽  
Pancreatic Neuroendocrine Tumors ◽  
Pancreatic Pathology ◽  
Diagnostic Criterion

e16696 Background: Vascular endothelial growth factors (VEGF) and their receptors provide malignant tumors with new blood and lymphatic vessels. However, it is unknown whether their level in the blood can help to determine the tumor nature or to distinguish malignant pathology from chronic organ inflammation. The purpose of the study was to reveal the dynamics of VEGF in the blood of patients with chronic pancreatitis and pancreatic cancer. Methods: The study included male patients with chronic pancreatitis (n = 9), pancreatic adenocarcinoma T1-3N0-1M0 (n = 10) and pancreatic neuroendocrine tumors T1-3N0-1M0 (n = 12) before treatment. Healthy males (n = 21) were controls. Blood levels of VEGF-A, VEGF-C, VEGF-R1 and VEGF-R3 were determined by ELISA using standard test systems (Cusabio, China). Results: VEGF-A in the blood of patients with pancreatic cancer increased: in adenocarcinoma by 2.6 times, in neuroendocrine tumors by 1.7 times (p < 0.05), while chronic pancreatitis was characterized with reduced VEGF-A in the blood – 2.2 times lower than in healthy people. Serum concentration of VEGF-C increased only in patients with adenocarcinoma – 1.3 times higher than the norm (p < 0.05). The amount of VEGF-R1 and VEGF-R3 receptors increased in the blood of patients with chronic pancreatitis (by 2.2 and 1.6 times respectively, p < 0.05) and pancreatic neuroendocrine tumors (2.2 and 1.3 times, p < 0.05). Conclusions: The rise of VEGF-A in the blood is a sign of malignant pancreatic pathology; its combination with the accumulation of VEGF-C in the blood is a diagnostic criterion for pancreatic adenocarcinoma, and a combination with an increase in VEGF-R1 and VEGF-R3 is a diagnostic criterion for pancreatic neuroendocrine tumors. In contrast, chronic pancreatitis is characterized by reduced VEGF-A together with the increase in both types of receptors in the blood.

Expression of cancer testis antigens in pancreatic carcinoma cell lines, pancreatic adenocarcinoma and chronic pancreatitis

2004 ◽  
Vol 109 (4) ◽  
pp. 568-575 ◽  
Author(s):  
Boris Kubuschok ◽  
Xiaoxiun Xie ◽  
Ralf Jesnowski ◽  
Klaus-Dieter Preuss ◽  
Bernd F.M. Romeike ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Carcinoma ◽  
Pancreatic Adenocarcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Carcinoma Cell Lines ◽  
Cancer Testis Antigens ◽  
Cancer Testis

scholarly journals CFTR F508del mutation and 5T allele in patients with chronic pancreatitis and pancreatic adenocarcinoma

2011 ◽  
Vol 58 (3) ◽  
pp. 43-47
Author(s):  
Aleksandra Nikolic ◽  
Jelena Dinic ◽  
Dragica Radojkovic ◽  
Snezana Lukic ◽  
Dragan Popovic ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Chronic Pancreatitis ◽  
Pancreatic Adenocarcinoma ◽  
Genetic Variants ◽  
Cftr Gene ◽  
Common Mutation ◽  
Healthy Individuals ◽  
Pancreatic Diseases ◽  
Pancreatic Disorders ◽  
Pancreatic Pathology

Introduction: Mutations in the CFTR gene may be associated with various types of pancreatic pathology and result in higher risk of pancreatic disorders. While delta F508 is the most common mutation in cystic fibrosis patients, the allel 5T is associated with atypical forms of cystic fibrosis. Study aim: The aim of this study was to establish the frequencies of F508del mutation and 5T allele in the CFTR gene in patients with chronic pancreatitis and pancreatic cancer, as well as to investigate whether these genetic variants represent risk factors for pancreatic diseases. Study methods: The study has encompassed 50 patients with chronic pancreatitis and 50 patients with pancreatic adenocarcinoma, as well as 124 healthy individuals. The analysis of F508del mutation and alleles 5T, 7T and 9T of the polythymidine tract was performed on DNA extracted from periferal blood by PCR-mediated site-direted mutagenesis (PSM) method. Results: The frequency of F508del mutation in the group of patients with chronic pancreatitis (3.0%) was significantly increased (p=0.032) in comparison to the group of healthy individuals (0.4%), while other analyzed differences were not statistically significant. Conclusion: The results of this study indicate that F508del mutation in the CFTR gene respresents a risk factor for the development of chronic pancreatitis.

Sign in / Sign up

Export Citation Format

Share Document