Recent Advances in the Transition-Metal-Free Arylation of Heteroarenes

Synthesis ◽  
2021 ◽  
Author(s):  
sefa ucar ◽  
Arif Dastan
Keyword(s):  
Transition Metal ◽  
Comprehensive Overview ◽  
Metal Free ◽  
The Past ◽  
Recent Advances

Transition-metal-free arylation reactions have attracted considerable attention, because of economic and environmental reasons over the past 40 years. In recent years, in particular, many efforts have been made to develop efficient transition-metal-free approaches for the arylation of heteroarenes. Covering the literature from 2015 to early 2021, this review aims to provide a comprehensive overview of the synthetic and mechanistic aspects of these atom economical and environmentally harmless reactions. 1 Introduction 2 Arylation of Pre-functionalized Heteroarenes 3 Direct C-H Arylation of Heteroarenes 3.1 C(Sp2)-H Arylation 3.2 C(sp3)-H Arylation 4 N-Arylation of Heteroarenes 5 Summary and Outlook

Recent Progress in Amination Enabled by Transition-Metal-Free C(sp2)–O/C(sp2)–S Bond Cleavage Strategy

Synthesis ◽  
2021 ◽  
Author(s):  
Xin-Ge Yang ◽  
Xue-Qiang Wang ◽  
Shen-Huan Li ◽  
Cheng-Yu Long
Keyword(s):  
Transition Metal ◽  
Natural Product ◽  
Aromatic Amines ◽  
Recent Progress ◽  
Bond Cleavage ◽  
Metal Free ◽  
Complementary Methods ◽  
The Past ◽  
Recent Advances ◽  
Metal Catalyzed

AbstractRecently, intense efforts have been dedicated to the development of novel synthetic strategies to access aromatic amines due to their importance in the pharmaceuticals, agrochemicals, materials, and natural product areas. Although numerous transition-metal-catalyzed C–N formation strategies have been described for the preparation of aromatic amines in the past few decades, complementary methods under transition-metal-free conditions are still required. We present the recent advances in the exploration of innovative amination approaches via C(sp2)–O/C(sp2)–S bond cleavage in this review.1 Introduction2 Stoichiometric Base-Promoted Amination3 Base-Catalyzed Amination4 Photoredox-Catalyzed Amination5 Acid-Promoted Amination6 Conclusion and Perspectives

Five-Membered Hetarene N-Oxides: Recent Advances in Synthesis and Reactivity

Synthesis ◽  
2021 ◽  
Author(s):  
Leonid Fershtat ◽  
Fedor Teslenko
Keyword(s):  
Transition Metal ◽  
Medicinal Chemistry ◽  
Materials Science ◽  
State Of The Art ◽  
Short Review ◽  
Advanced Materials ◽  
Metal Free ◽  
Recent Advances ◽  
Application Potential ◽  
Metal Catalyzed

Five-membered heterocyclic N-oxides attracted special attention due to their strong application potential in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are constantly required. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are briefly summarized. Main routes to transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. Transformation patterns of the hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented.

Transition metal-free decarboxylative alkylation reactions

2016 ◽  
Vol 14 (46) ◽  
pp. 10763-10777 ◽  
Author(s):  
Ping Liu ◽  
Guanghui Zhang ◽  
Peipei Sun
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
Metal Free ◽  
Recent Advances ◽  
Alkylation Reactions

This review summarizes recent advances in the transition metal-free decarboxylative alkylation of carboxylic acids and their derivatives.

Recent Advances in Radical Initiated C-N Bond Formation under Transition Metal-Free Conditions

2017 ◽  
Vol 37 (3) ◽  
pp. 566 ◽  
Author(s):  
Sitian Yuan ◽  
Yanhua Wang ◽  
Guanyinsheng Qiu ◽  
Jinbiao Liu
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Metal Free ◽  
Recent Advances

scholarly journals Recent advances in the transition-metal-free synthesis of quinoxalines

RSC Advances ◽  
2021 ◽  
Vol 11 (59) ◽  
pp. 37325-37353
Author(s):  
Biplob Borah ◽  
L. Raju Chowhan
Keyword(s):  
Transition Metal ◽  
Review Article ◽  
Metal Free ◽  
Recent Advances

Recent advances in the synthesis of quinoxalines under transition metal free conditions are summarized in this review article.

scholarly journals Recent Advances in Cyclization Reaction of Alkynes under Transition Metal-Free Conditions

2020 ◽  
Vol 40 (6) ◽  
pp. 1529
Author(s):  
Lei Zhang ◽  
Sitian Yuan ◽  
Peng Wang ◽  
Jinbiao Liu
Keyword(s):  
Transition Metal ◽  
Cyclization Reaction ◽  
Metal Free ◽  
Recent Advances

Oxford Textbook of Rheumatoid Arthritis

2020 ◽  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Presentation ◽  
Disease Assessment ◽  
Future Research ◽  
Clinical Aspects ◽  
Comprehensive Overview ◽  
Future Directions ◽  
The Past ◽  
Recent Advances ◽  
Drug Treatments

This new textbook provides a comprehensive overview of the scientific and clinical aspects of rheumatoid arthritis (RA). Split into eight sections—history, diagnosis, and epidemiology; pathogenesis; clinical presentation; disease assessment; impact on life; non-drug treatments; drug treatments; and management and outcomes—it collects the contemporary ideas about RA and explains the revolutionary changes that have taken place over the past two decades, and indicates areas of future research. Witten by leading clinicians and scientists in the field, each chapter gives a detailed background, key recent advances, areas of doubt, and future directions of research.

scholarly journals Recent advances in transition metal-free catalytic hydroelementation (E = B, Si, Ge, and Sn) of alkynes

RSC Advances ◽  
2020 ◽  
Vol 10 (71) ◽  
pp. 43539-43565
Author(s):  
Vitthal B. Saptal ◽  
Ruibin Wang ◽  
Sehoon Park
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Recent Advances

This review describes the recent advances in the transition metal-free hydroelementation of alkynes with various metalloid hydrides.

Recent Advances of Transition-Metal-Free Trifluoromethylation with Togni’s Reagents

2022 ◽  
Author(s):  
Jin-Yang Chen ◽  
Jing Huang ◽  
Kai Sun ◽  
Wei-Min He
Keyword(s):  
Transition Metal ◽  
Organic Transformations ◽  
Metal Free ◽  
Recent Advances

Developments in transition-metal-free trifluoromethylation have attracted broad interests driven by the increasing importance of CF3-containing compounds. Among diverse trifluoromethylation reagents, Togni’s reagents displayed exceptional reactivities, and abundant meaningful organic transformations...

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