Preoperative evaluation and optimization of medical status of patients are important components of anesthesia practice. Increasing numbers of patients with serious comorbidities undergo procedures that require anesthesia services outside of the operating room (OOOR). Often the location alters the challenges of caring for these patients. Surgical, anesthesia, or nursing personnel who can assist with airway and resuscitation management may not be available; equipment and medications may be limited. Many OOOR locations will not have the usual support of an intensive care unit (ICU), skilled postanesthesia recovery personnel, respiratory therapy, or ready access to an inpatient bed, blood banking, interventional cardiology, or diagnostic services. Many of the patients are elderly, ill, and even unlikely candidates for conventional surgery (e.g., transmucosal resection of gastric tumors, transjugular intrahepatic portosystemic shunts). Yet patients and/or providers may be reluctant to expend time and energy in extensive preoperative evaluation before a seemingly minor procedure. This chapter will outline the basics of preprocedure preparation of patients scheduled to receive anesthesia in OOOR settings.