Identification and chemical study of plants used in the traditional treatment of Buruli Ulcer in Benin

Sickle cell disease is a hemoglobinopathy. In hypoxia situation, homozygous individuals might suffer from vaso-occlusive seizures, hemolytic anemia and increased susceptibility to infections. A recipe of the leaves of Ficus carpensis, Newbouldia laevis, Carpolobia lutea and Carpolobia caudate, four plants used in the traditional treatment of sickle cell disease in the Daloa region, was the subject of this study. This investigation was initiated in order to assess sickle cell inhibitory activity of the recipe, by using Emmel’s method. The decocted (DS) and the aqueous extract (EA) of the recipe brought the residual sickle cell rate at 10 and 11% respectively. Which correspond to sickle cell inhibitory activity of 90% for the decocted (DS) and 89% for the aqueous extract (EA). These activities were higher than that of phenylalanine (83%) which is used as an antisickling amino acid reference. The chemical study of the both extracts of the recipe revealed the presence of compounds known for their anti-oxidant and anti-sickle cell activities. Those flavonoids, polyphenols and alkaloids could be partly responsible for the sickle cell inhibitory activity of the recipe. These results showed that both the extracts of the recipe had antisickling activity. The use of this recipe of four plants in the traditional treatment of sickle cell disease in the Daloa region might be justified.

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Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation andIn VitroActivity of Alkaloids Isolated fromHolarrhena floribundaUsed in Traditional Treatment of Buruli Ulcer

BioMed Research International ◽

10.1155/2015/835767 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Achille Yemoa ◽

Joachim Gbenou ◽

Dissou Affolabi ◽

Mansourou Moudachirou ◽

André Bigot ◽

...

Keyword(s):

Buruli Ulcer ◽

Cost Effective ◽

Antimycobacterial Activity ◽

Mycobacterium Ulcerans ◽

Traditional Treatment ◽

Aerial Parts ◽

Antimycobacterial Agents ◽

Pharmacologically Active ◽

Hydroethanolic Extract

Buruli ulcer (BU) imposes a serious economic burden on affected households and on health systems that are involved in diagnosing the disease and treating patients. Research is needed to find cost-effective therapies for this costly disease. Plants have always been an important source of new pharmacologically active molecules. Consequently we decided to undertake the study of plants used in traditional treatment of BU in Benin and investigate their antimycobacterial activity as well as their chemical composition. Extracts from forty-four (44) plant species were selected on account of reported traditional uses for the treatment of BU in Benin and were assayed for antimycobacterial activities. Crude hydroethanolic extract from aerial parts ofHolarrhena floribunda(G. Don) T. Durand and Schinz was found to have significant antimycobacterial activity againstM.ulcerans(MIC = 125 µg/mL). We describe here the identification of four steroidal alkaloids fromMycobacterium ulceransgrowth-inhibiting fractions of the alkaloidal extract of the aerial parts ofHolarrhena floribunda. Holadysamine was purified in sufficient amount to allow the determination of its MCI (=50 µg/mL). These results give some support to the use of this plant in traditional medicine.

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Traditional treatment of Buruli ulcer in Benin

Archives of Dermatology ◽

10.1001/archderm.131.6.741 ◽

1995 ◽

Vol 131 (6) ◽

pp. 741-742 ◽

Cited By ~ 10

Author(s):

A. Guedenom

Keyword(s):

Buruli Ulcer ◽

Traditional Treatment

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Traditional Treatment of Buruli Ulcer in Bénin

Archives of Dermatology ◽

10.1001/archderm.1995.01690180121030 ◽

1995 ◽

Vol 131 (6) ◽

pp. 741

Author(s):

C. Zinsou

Keyword(s):

Buruli Ulcer ◽

Traditional Treatment

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Chemical study on Paenibacillus odorifer, a bacterial species isolated from lichen

Planta Medica ◽

10.1055/s-0036-1596731 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

N Thi Bach Le ◽

D David ◽

T Sophie

Keyword(s):

Bacterial Species ◽

Chemical Study

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A QUANTUM CHEMICAL STUDY OF THE MOLECULAR STRUCTURE OF ZINC(II) AND BORON(III) COMPLEXES WITH MONOIODO AND DIBROMO SUBSTITUTED DIPYRRINES

Журнал структурной химии ◽

10.15372/jsc20160104 ◽

2016 ◽

Vol 57 (1) ◽

Keyword(s):

Molecular Structure ◽

Quantum Chemical ◽

Quantum Chemical Study ◽

Chemical Study

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Delayed Treatment of Spinal Cord Injury In Young: A Case Report

Neurologico Spinale Medico Chirurgico ◽

10.15562/nsmc.v1i2.93 ◽

2018 ◽

Vol 1 (2) ◽

pp. 15

Author(s):

Joshua Sutikno

Keyword(s):

Spinal Cord ◽

Spinal Cord Injury ◽

Traffic Accidents ◽

Epidemiological Data ◽

Morbidity Rate ◽

High Morbidity ◽

Low Back ◽

Traditional Treatment ◽

Delayed Treatment ◽

Cord Injury

Background: Spinal cord injury (SCI), one of the problems caused by traffic accidents, has a high morbidity in developing country like Indonesia. In Indonesia, the use of motorcycles is increasing every year. The epidemiological data from Fatmawati Hospital of spinal cord injury in 2014 was 104 cases both traumatic and non-traumatic SCI. In this case, a young boy with worsening of SCI, delayed the treatment for about 3 months.Case: A 19 years-old male complained of limbs paralysis for the past two weeks. He felt numbness and tingling in hamstring and calf areas. From past medical history, he had a motorcycle accident 3 months prior. After the accident, he suffered from extreme low back pain, but he could still move his legs. Due to economic restrictions, the patient refused to go to the hospital, and they chose a traditional treatment. For about three months, the pain was decreasing, but he was never pain-free. As the symptoms continued to worsen, the neurosurgeon decided to decompress the spinal cord and performed discectomy. After a week of treatment, the pain disappeared, motor muscle got better, and he could feel again the sensation on the dermatome of S1. Conclusion: Early treatment is recommended to get a better outcome. The surgery is not the only treatment, rehabilitation and orthotics using are important too. Delayed treatment increases morbidity rate.

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