Drug-Induced Changes of Physiologically Active Agents in the Central Nervous System and Their Significance

1969 ◽  
Vol 2 (03) ◽  
pp. 176-190 ◽  
Author(s):  
H.-H. Frey
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Induced ◽  
The Central Nervous System ◽  
Induced Changes

scholarly journals Acute Graft-Versus-Host Disease, Infections, Vascular Events and Drug Toxicities Affecting the Central Nervous System

2021 ◽  
Vol 12 ◽  
Author(s):  
Janaki Manoja Vinnakota ◽  
Robert Zeiser
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Gvhd ◽  
Hematopoietic Cell Transplantation ◽  
Neurological Deficits ◽  
Vascular Events ◽  
Drug Induced ◽  
Curative Therapy ◽  
The Central Nervous System ◽  
Acute Graft

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for patients with hematological malignancies. Acute Graft versus host diseases (GVHD) is a major immune mediated side effect of allo-HCT that can affect the central nervous system (CNS) in addition to post-allo-HCT vascular events, drug toxicity or infections. Here we summarize and discuss recent preclinical data on the CNS as a target of acute GVHD and the known mechanisms contributing to neurotoxicity with a focus on microglia and T cells. We also discuss open questions in the field and place the findings made in mouse models in a clinical context. While in mice the neurological deficits can be assessed in a controlled fashion, in patients the etiology of the CNS damage is difficult to attribute to acute GVHD versus infections, vascular events, and drug-induced toxicity. Ultimately, we discuss novel therapies for GVHD of the CNS. Our understanding of the biological mechanisms that lead to neurotoxicity after allo-HCT increased over the last decade. This review provides insights into CNS manifestations of GVHD versus other etiologies of CNS damage in mice and patients.

Recognizing Radiation-induced Changes in the Central Nervous System: Where to Look and What to Look For

Radiographics ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 224-248
Author(s):  
Masaki Katsura ◽  
Jiro Sato ◽  
Masaaki Akahane ◽  
Toshihiro Furuta ◽  
Harushi Mori ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radiation Induced ◽  
The Central Nervous System ◽  
Induced Changes

MULTIPLE MALFORMATIONS STUDIED WITH A NATIONAL REGISTER OF MALFORMATIONS

PEDIATRICS ◽  
1969 ◽  
Vol 44 (3) ◽  
pp. 410-417
Author(s):  
Bengt Källén ◽  
Jan Winberg
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Congenital Malformations ◽  
Cleft Lip ◽  
Simultaneous Occurrence ◽  
National Register ◽  
Drug Induced ◽  
Malformation Syndrome ◽  
Specific Syndrome ◽  
The Central Nervous System

An analysis was performed of 120 children, born with multiple malformations and reported to the Swedish national register of congenital malformations. The simultaneous occurrence of two or more specific malformations may be random or due to the presence of a specific syndrome. A statistical analysis demonstrates that specific associations do occur between certain malformations, and one "new" syndrome was found, consisting of closure defects of the central nervous system, an- or microphthalmia, cleft lip and/or cleft palate, and reduction malformations of the limbs, not related to the amelia-phocomelia group. Children with this constellation of malformations were especially common during the first half of 1965. Its cause is unknown. The method of analysis presented may be useful for an early detection of a new, drug-induced malformation syndrome.

Drug-induced atrial fibrillation/flutter associated with drugs affecting the central nervous system

Pharmateca ◽  
2021 ◽  
Vol 3_2021 ◽  
pp. 10-17
Author(s):  
O.D. Ostroumova Ostroumova ◽  
M.S. Cherniaeva Cherniaeva ◽  
O.M. Maslennikova Maslennikova ◽  
O.V. Zykova Zykova ◽  
A.G. Komarova Komarova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Central Nervous System ◽  
Nervous System ◽  
Drug Induced ◽  
The Central Nervous System

In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System

1999 ◽  
Vol 43 (8) ◽  
pp. 2101-2101
Author(s):  
Hideki Kita ◽  
Hirotami Matsuo ◽  
Hitomi Takanaga ◽  
Junichi Kawakami ◽  
Koujirou Yamamoto ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
The Central Nervous System ◽  
Anti Inflammatory

Radiation-induced changes in the central nervous system and head and neck.

Radiographics ◽  
1996 ◽  
Vol 16 (5) ◽  
pp. 1055-1072 ◽  
Author(s):  
B M Rabin ◽  
J R Meyer ◽  
J W Berlin ◽  
M H Marymount ◽  
P S Palka ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Head And Neck ◽  
Radiation Induced ◽  
The Central Nervous System ◽  
Induced Changes

Progesterone modulates diabetes/hyperglycemia-induced changes in the central nervous system and sciatic nerve

Neuroscience ◽  
2017 ◽  
Vol 350 ◽  
pp. 1-12 ◽  
Author(s):  
Fahim Atif ◽  
Megan C. Prunty ◽  
Nefize Turan ◽  
Donald G. Stein ◽  
Seema Yousuf
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sciatic Nerve ◽  
The Central Nervous System ◽  
Induced Changes
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