Antiviral treatment with peginterferon plus Ribavirin reduces serum leptin levels in patients with chronic hepatitis C

2010 ◽  
Vol 48 (05) ◽  
Author(s):  
C Putz-Bankuti ◽  
T Stojakovic ◽  
H Scharnagl ◽  
B Bauer ◽  
H Pock ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Serum Leptin

MS456 EFFECTS OF ANTIVIRAL TREATMENT ON SERUM LEPTIN LEVELS AND LIPID PROFILE IN PATIENTS WITH CHRONIC HEPATITIS C

2010 ◽  
Vol 11 (2) ◽  
pp. 202
Author(s):  
T. Stojakovic ◽  
C. Putz-Bankuti ◽  
H. Scharnagl ◽  
B. Bauer ◽  
H. Pock ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Lipid Profile ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Serum Leptin

scholarly journals HOMA, BMI, and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic, Nonobese, and Nondiabetic Chronic Hepatitis C Genotype 1 Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Alessandro Grasso ◽  
Federica Malfatti ◽  
Gabriella Andraghetti ◽  
Simona Marenco ◽  
Chiara Mazzucchelli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Genotype 1 ◽  
Serum Leptin ◽  
Peginterferon And Ribavirin ◽  
Chronic Hcv

Objective. To investigate the relationship between insulin resistance and viral load decay in nondiabetic and noncirrhotic genotype 1 chronic HCV patients during peginterferon and ribavirin treatment and the possible influence of BMI and leptin as metabolic confounders.Methods. 75 consecutive noncirrhotic, nonobese, and nondiabetic patients with genotype 1 chronic hepatitis C treated with peginterferon alpha 2a plus ribavirin were evaluated. HOMA-IR, serum leptin, and BMI were measured in all patients at baseline and at weeks 12 and 48, whereas viral load was measured at the same time points and then 24 weeks after the end of treatment.Results. HOMA-IR was significantly associated with both BMI and leptin at baseline. During peginterferon plus ribavirin treatment, there was a significant reduction of HOMA-IR at weeks 12 and 48 from baseline (P=0.033and 0.048, resp.) in patients who achieved an early viral load decay (EVR), a trend not observed in patients who not achieved EVR. No variations during treatment were observed regarding BMI and leptin irrespective of EVR.Conclusion. The early reduction of HOMA-IR but not of BMI and leptin during antiviral treatment in noncirrhotic, chronic hepatitis C genotype 1 patients who achieved EVR suggests a viral genesis of insulin resistance in patients with nonmetabolic phenotype.

Genetic polymorphisms as the predictors of response to antiviral treatment in chronic hepatitis C virus infection

2011 ◽  
Vol 152 (22) ◽  
pp. 876-881
Author(s):  
Alajos Pár
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Polymorphisms ◽  
Chronic Hepatitis C ◽  
Genome Wide Association Study ◽  
Antiviral Treatment ◽  
Hcv Infection ◽  
Snp Analysis ◽  
Chronic Hcv

The review discusses the genetic polymorphisms involved in the pathogenesis of hepatitis C virus (HCV) infection, that may determine the outcome of disease. In this field earlier both certain major histocompatibility complex (MHC) alleles and some cytokine gene variants have also been studied. Recently, the genome-wide association study (GWAS) and targeted single nucleotide polymorphism (SNP) analysis have revealed that a variant in the promoter region of interleukin-28B (IL-28B) gene is strongly linked to viral clearance and it may be the strongest pretreatment predictor of treatment response in chronic hepatitis C. Last year it was shown that two genetic variants leading to inosine triphosphatase deficiency protect against haemolytic anemia in patients receiving ribavirin during antiviral treatment for chronic HCV infection. Orv. Hetil., 2011, 152, 876–881.

The Effects of Interferon and Ribavirin in Chronic Hepatite C

2017 ◽  
Vol 68 (9) ◽  
pp. 2147-2150
Author(s):  
Liliana Coldea ◽  
Florin Grosu ◽  
Alina Liliana Pintea ◽  
Sebastian Ioan Cernusca Mitariu ◽  
Nicolae Grigore ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Public Health Problem ◽  
Complete Response ◽  
Extrahepatic Manifestations ◽  
Hépatite C ◽  
Response Versus

The chronic hepatitis C is a frequently problem in worldwide, the number of infected individuals is high and go on, getting a public health problem [1]. In Romania there are nearly 1 million persons infected with hepatitis C virus, the scope of spreading is related with specific risk factors. An important number of infection with hepatitis C virus present simultaneous extrahepatic manifestations proved to be alone manifestation tracing; its important for diagnosis and treatment. We analyzed the effects of interferon and ribavirin in chronic hepatitis C in General C.F. Hospital Sibiu, between 2008 � 2012. The association between infection with hepatitis C virus and extrahepatic manifestations is important to be recognized for adequate diagnosis tests. By comparing the results of therapy in patients with hepatic and extrahepatic manifestations, the study found that 30 patients (58.83 %) with liver manifestations had an incomplete response versus 10 patients (26.32 %) with extrahepatic manifestations; 11 patients (21.54 %) with hepatic manifestations had a complete response versus 3 patients (7.89 %) with extrahepatic manifestations; and 10 patients (19.63 %) with hepatic manifestations did not respond to treatment versus 25 patients (65.79 %) with extrahepatic manifestations. Analyzing the results of antiviral therapy in patients with hepatic manifestations and those with extrahepatic manifestations, antiviral treatment appears to be more advantageous in cases with only hepatic manifestations.

scholarly journals Interferon-free antiviral treatment of chronic hepatitis C in the transplant setting

2015 ◽  
Vol 28 (9) ◽  
pp. 1011-1024 ◽  
Author(s):  
Sandra Beinhardt ◽  
Markus Peck-Radosavljevic ◽  
Harald Hofer ◽  
Peter Ferenci
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment

scholarly journals Pleuro-Pulmonary Nocardiosis as Opportunistic Infection in a Patient with Chronic Hepatitis C under Combination Treatment with Pegylated Interferon, Ribavirin, and Boceprevir

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Csilla Putz-Bankuti ◽  
Harald H. Kessler ◽  
Thomas Valentin ◽  
Eva Leitner ◽  
Emina Talakic ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Pulmonary Infection ◽  
Antiviral Treatment ◽  
Pegylated Interferon ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Aerobic Actinomycetes

Nocardiosis is an infrequent but serious pulmonary infection caused by Gram-positive aerobic actinomycetes. In this paper, we report on a 48-year-old patient with pleuropulmonary nocardiosis and cirrhosis due to chronic hepatitis C virus infection treated with triple antiviral treatment complicated by prolonged neutropenia.

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