Assessing Connectivity in stroke patients: the relationship between effective connectivity in the motor system and electrophysiological excitability of the cortico-spinal system in chronic stroke patients

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
A.S. Sarfeld ◽  
S. Diekhoff ◽  
A.K. Rehme ◽  
S. Eickhoff ◽  
G.R. Fink ◽  
...  
2018 ◽  
Vol 24 (8) ◽  
pp. 6225-6231
Author(s):  
S Rachmayanti ◽  
W Kusumaningsih

Hypertension and diabetes mellitus are the most common risk factors of stroke.The study aimed to determine the relationship between stroke risk factors, hypertension and diabetes mellitus, with dependency of chronic stroke patients in Department of Medical Rehabilitation RSCM. The study is conducted by using the analytical observational cross-sectional study. The samples used in this study were 44 respondents selected by quota sampling method. The relationship between variabels was analyzed by bivariate test Chi-Square and multivariate analysis: Logistic Regression. Based on Chi-Square test, relationship between MSBI scoring with hypertension and diabetes mellitus as stroke risk factors, sequentiallly p = 0,122 and p = 0,002. Furthermore, Logistic Regression test suggested that hypertension and diabetes mellitus as stroke risk factors related to MSBI scoring, respectively; hypertension p = 0,076 (OR 4,076; CI95 0,861–19,297) and diabetes mellitus p = 0,007 (OR 22,690; CI95 2,332–220,722). Discussion: Diabetes mellitus is the most prominent risk factor in severe dependecy of chronic stroke patients.


2021 ◽  
Vol 15 (3) ◽  
pp. 185-192
Author(s):  
Lale Lajevardi ◽  
◽  
Ghorban Taghizade ◽  
Zahra Parnain ◽  
◽  
...  

Background and Objectives: Cognitive and psychological impairments are among the disabling consequences of chronic stroke. Despite the high prevalence of these impairments in patients with chronic stroke and the significant impact of psychological factors on cognitive factors in other neurological diseases, no study was found to investigate the relationship between psychological factors and cognitive factors in chronic stroke patients with chronic fatigue. Therefore, this study aimed to investigate the relationship between psychological factors and cognitive functions in chronic stroke patients with chronic fatigue Methods: A total of 85 chronic stroke patients with chronic fatigue visited the Rehabilitation Centers of Tehran, Iran, were selected through the simple non-probability sampling method and enrolled in this correlational study. The Fatigue Severity Scale, Beck Depression Inventory, and Beck Anxiety Inventory were used to measure the levels of the fatigue, depression, and anxiety of patients with strokes, respectively. Besides, the cognitive functions of the participants were assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pain Visual Analog Scale. Results: Based on the regression models, the Mini-Mental State Examination and the Montreal Cognitive Assessment explained up to 24.2% and 39.6% of the variance of cognitive functions, respectively. In all step-by-step models, the variables of anxiety, education level, and depression were the strongest predictors of cognitive functions. Conclusion: According to the clinical findings, psychological impairments, such as anxiety can adversely affect cognitive factors in chronic stroke patients with chronic fatigue. Therefore, therapeutic interventions focused on psychological factors may considerably improve the cognitive skills of these patients.


Author(s):  
Giulia Lioi ◽  
Adolfo Veliz ◽  
Julie Coloigner ◽  
Quentin Duché ◽  
Simon Butet ◽  
...  

Author(s):  
Katsuhiro Nishino ◽  
Suguru Yamaguchi ◽  
Kousuke Matsuzono ◽  
Hiroyuki Yamamoto

The results showed that the range of motion (ROM) was improved in 6 out of 7 cases, while fine movement of the hand was also improved in 4 cases. These improvements were observed a few days after the initiation of whole-hand electrical neural stimulation. In one chronic stroke case, the treatment resulted in an almost full recovery of hand control during the first 30 minutes of sub-threshold sensory stimulation, including pinching and grasping. This dramatic recovery led the authors to hypothesize that the responder would show no lesioning of the motor cortex on CT or MRI images. While more cases are needed to test the limitations of this modality and to determine the relationship between the level of recovery and the topology of CNS lesioning, this work illustrates the utility of this approach for improving motor control of the hand in chronic stroke patients.


2014 ◽  
Vol 112 (9) ◽  
pp. 2251-2263 ◽  
Author(s):  
Julià L. Amengual ◽  
Thomas F. Münte ◽  
Josep Marco-Pallarés ◽  
Nuria Rojo ◽  
Jennifer Grau-Sánchez ◽  
...  

Stroke induces a loss of neural function, but it triggers a complex amount of mechanisms to compensate the associated functional impairment. The present study aims to increase our understanding of the functional reshape of the motor system observed in chronic stroke patients during the preparation and the execution of movements. A cohort of 14 chronic stroke patients with a mild-to-moderate hemiparesis and 14 matched healthy controls were included in this study. Participants were asked to perform a bimanual reaction time task synchronizing alternated responses to the presentation of a visual cue. We used Laplacian-transformed EEG activity (LT-EEG) recorded at the locations Cz and C3/C4 to study the response-locked components associated with the motor system activity during the performance of this task. Behaviorally, patients showed larger variable errors than controls in synchronizing the frequency of execution of responses to the interstimulus interval, as well as slower responses compared with controls. LT-EEG analysis showed that whereas control participants increased their supplementary motor area (SMA) activity during the preparation of all responses, patients only showed an increment of activity over this area during their first response of the sequence. More interestingly, patients showed a clear increment of the LT-EEG activity associated with SMA shortly after motor responses as compared to the control participants. Finally, patients showed a hand-dependent inhibitory activity over motor areas ipsilateral to the response hand. Overall, our findings reveal drastic differences in the temporal dynamics of the LT-EEG components associated with the activity over motor and premotor cortices in chronic stroke patients compared with matched control participants during alternated hand responses.


2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Leonardo Bonilha ◽  
Travis Nesland ◽  
Chris Rorden ◽  
Paul Fillmore ◽  
Ruwan P. Ratnayake ◽  
...  

Background. The extent of brain damage in chronic stroke patients is traditionally defined as the necrotic tissue observed on magnetic resonance image (MRI). However, patients often exhibit symptoms suggesting that functional impairment may affect areas beyond the cortical necrotic lesion, for example, when cortical symptoms ensue after subcortical damage. This observation suggests that disconnection or diaschisis can lead to remote cortical dysfunction that can be functionally equivalent to direct cortical lesions.Objective. To directly measure subcortical disconnection after stroke.Methods. We describe a principled approach utilizing the whole brain connectome reconstructed from diffusion MRI to evaluate the reduction of apparent white matter fiber density in the hemisphere affected by the stroke compared with the spared hemisphere.Results. In eight chronic stroke patients, we observed subcortical disconnection extending beyond the location of tissue necrosis and affecting major white matter pathways underlying the necrotic area.Conclusions. We suggest that it is possible to detect and quantify previously unappreciated areas of subcortical and cortical disconnection. Specifically, this method can be used to evaluate the relationship between lesion location and symptoms, with emphasis on a connectivity-based approach.


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