Exploring the CNS effects of acupuncture needling with TMS

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
M Zunhammer ◽  
V Busch ◽  
J Franz ◽  
J Haas ◽  
P Eichhammer
Keyword(s):  
Cns Effects

scholarly journals The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice

2018 ◽  
Vol 7 (12) ◽  
pp. 2389
Author(s):  
Amit S. Kamdi ◽  
Sarika D. Kokane ◽  
Pankaj N. Bohra ◽  
Suvarna M. Kalambe
Keyword(s):  
Avoidance Response ◽  
Conditioned Avoidance ◽  
Conditioned Avoidance Response ◽  
P Value ◽  
Alcoholic Extract ◽  
Swiss Albino Mice ◽  
Withania Coagulans ◽  
Antipsychotic Activity ◽  
Albino Mice ◽  
Cns Effects

Background: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines. The numerous antipsychotic medications used today are not lacking the adverse drug reactions. The Withania coagulans a susceptible species, is not explored much for its CNS effects except in late seventies. Therefore, it was thought worthwhile to investigate anti-psychotic activities of alcoholic extract of Withania coagulans fruits. The objective of the present study was to assess the antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Cook’s Pole Climb Apparatus for conditioned avoidance response (CAR)Methods: Cook’s Pole Climb Apparatus for conditioned avoidance response was used for assessing the antipsychotic activity of the alcoholic extract of 200mg/kg, 500mg/kg and 1000mg/kg doses of Withania coagulans fruits.Results: There was statistically (p-value >0.05) no significant association between any of the 200mg/kg, 500mg/kg and 1000mg/kg doses of the alcoholic extracts of Withania coagulans fruits with antipsychotic activity in Swiss albino mice.Conclusions: Withania coagulans fruits alcoholic extract did not demonstrate antipsychotic activity in Swiss albino mice under standard conditions.

Efficacy, safety and CNS effects after switch from efavirenz/tenofovir/emtricitabine to doravirine/tenofovir/lamivudine in a randomized controlled trial

AIDS ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Mark Nelson ◽  
Alan Winston ◽  
Andrew Hill ◽  
Rosie Mngqibisa ◽  
Ayesha Bassa ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Cns Effects

Non-sedative antihistamines: ▾ terfenadine and ▾ astemizole

1984 ◽  
Vol 22 (6) ◽  
pp. 21-23
Keyword(s):  
Allergic Rhinitis ◽  
Histamine Release ◽  
Cns Effects

Terfenadine (Triludan - Merrell) and astemizole (Hismanal - Janssen) are two chemically unrelated oral H1-receptor antihistamines marketed recently for the relief of allergic rhinitis, conjunctivitis and other manifestations of histamine release, such as urticaria. Both are claimed to be free of the usual anticholinergic and CNS effects, especially sedation, which limit the use of other H1 antihistamines. If this major claim justified?

Elucidating the Phytochemical and Pharmacological Potential of Myristica fragrans (Nutmeg)

2020 ◽  
pp. 52-61 ◽  
Author(s):  
Ena Gupta
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Daily Intake ◽  
Low Doses ◽  
Acceptable Daily Intake ◽  
Bioactive Constituents ◽  
Myristica Fragrans ◽  
The Family ◽  
Pharmacological Potential ◽  
Cns Effects

Myristica fragrans or nutmeg is a ground spice of the family Myristicaceae. Its tree has dark leaves mainly cultivated in Grenada, Malaysia, and Kerala. It is majorly a source of two spices derived from its fruit: nutmeg (jaiphal) from its seed and mace (javitri) from the covering of seed. The important bioactive constituents present in nutmeg include macelignan, carvacrol, myristicin, β-caryophyllene, β-pinene, α-pinene, p-cymene, and eugenol. Low doses of nutmeg do not cause any side effects whereas after consuming 5g toxic overdose occurs, and central nervous system (CNS) effects were induced after consuming 1 to 2 mg/kg b.wt. of nutmeg. Various therapeutic or medicinal applications were shown by nutmeg such as antioxidant, antimicrobial, aphrodisiac, anticancer, hepatoprotective, anti-inflammatory, antidepressant, and cardioprotective activity. This review chapter focuses on ethnobotany, phytochemistry, acceptable daily intake, and different pharmacological actions of this medicinal plant.

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