Non-invasive imaging of endogenous neural stem cell mobilization in vivo using Positron Emission Tomography

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
MA Rueger ◽  
H Backes ◽  
M Walberer ◽  
B Neumaier ◽  
R Ullrich ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Mobilization ◽  
Emission Tomography ◽  
Non Invasive ◽  
Positron Emission ◽  
Cell Mobilization

scholarly journals Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Martin Thunemann ◽  
Barbara F. Schörg ◽  
Susanne Feil ◽  
Yun Lin ◽  
Jakob Voelkl ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Cell Populations ◽  
Specific Cell ◽  
Non Invasive ◽  
Positron Emission

scholarly journals Non-invasive imaging of high-risk coronary plaque: the role of computed tomography and positron emission tomography

2020 ◽  
Vol 93 (1113) ◽  
pp. 20190740 ◽  
Author(s):  
Rong Bing ◽  
Krithika Loganath ◽  
Philip Adamson ◽  
David Newby ◽  
Alastair Moss
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Coronary Plaque ◽  
Emission Tomography ◽  
Plaque Morphology ◽  
Biological Processes ◽  
Non Invasive ◽  
Positron Emission

Despite recent advances, cardiovascular disease remains the leading cause of death globally. As such, there is a need to optimise our current diagnostic and risk stratification pathways in order to better deliver individualised preventative therapies. Non-invasive imaging of coronary artery plaque can interrogate multiple aspects of coronary atherosclerotic disease, including plaque morphology, anatomy and flow. More recently, disease activity is being assessed to provide mechanistic insights into in vivo atherosclerosis biology. Molecular imaging using positron emission tomography is unique in this field, with the potential to identify specific biological processes using either bespoke or re-purposed radiotracers. This review provides an overview of non-invasive vulnerable plaque detection and molecular imaging of coronary atherosclerosis.

scholarly journals Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nobuo Suzui ◽  
Takuya Shibata ◽  
Yong-Gen Yin ◽  
Yoshihito Funaki ◽  
Keisuke Kurita ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Iodide ◽  
Emission Tomography ◽  
Sodium Ions ◽  
Living Animal ◽  
Non Invasive ◽  
Positron Emission ◽  
Tracer Solution ◽  
The Impact

Abstract Visualizing the dynamics of cesium (Cs) is desirable to understand the impact of radiocesium when accidentally ingested or inhaled by humans. However, visualization of radiocesium in vivo is currently limited to plants. Herein, we describe a method for the production and purification of 127Cs and its use in visualizing Cs dynamics in a living animal. The positron-emitting nuclide 127Cs was produced using the 127I (α, 4n) 127Cs reaction, which was induced by irradiation of sodium iodide with a 4He2+ beam from a cyclotron. We excluded sodium ions by using a material that specifically adsorbs Cs as a purification column and successfully eluted 127Cs by flowing a solution of ammonium sulfate into the column. We injected the purified 127Cs tracer solution into living rats and the dynamics of Cs were visualized using positron emission tomography; the distributional images showed the same tendency as the results of previous studies using disruptive methods. Thus, this method is useful for the non-invasive investigation of radiocesium in a living animal.

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