Cytotoxicity of two medicinal plants commonly used in the management of diabetes in Eastern Cape South Africa using Chang liver cell lines

The effect of oil palm (Elaeis guineensis) fruit aqueous extract (OPF) on glucose uptake activity of three different cell lines was investigated. The cell lines were incubated with different concentrations of OPF to evaluate the stimulatory effect of OPF towards glucose uptake activity of L6 myotubes, 3T3F442A adipocytes and Chang liver cell line. The glucose uptake activities of all tested cells were enhanced in the presence of OPF extract (basal condition). Nevertheless in combination of OPF extract and 100 nM insulin, the glucose uptake activity was only significantly enhanced in L6 myotubes and 3T3F442A adipocytes cell lines. The extracts enhanced the glucose uptake into cells through either insulin-mimetic or insulin-sensitizing property or combination of these two properties. It can be suggested that the OPF extract exerts its antihyperglycemic action partly by mediated glucose uptake into the glucose-responsive disposal cells, muscle, adipose and liver.

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Medicinal Plants Used for the Traditional Management of Diabetes in the Eastern Cape, South Africa: Pharmacology and Toxicology

Molecules ◽

10.3390/molecules23112759 ◽

2018 ◽

Vol 23 (11) ◽

pp. 2759 ◽

Cited By ~ 8

Author(s):

Samuel Odeyemi ◽

Graeme Bradley

Keyword(s):

South Africa ◽

Medicinal Plants ◽

Scientific Evidence ◽

Traditional Healers ◽

Bioactive Molecules ◽

Eastern Cape ◽

Insulin Mimetic ◽

Almost All

The use of medicinal plants for the management of diabetes mellitus is on the rise in the developing countries, including South Africa. There is increasing scientific evidence that supports the claims by the traditional healers. In this review, we compare the families of previously reported anti-diabetic plants in the Eastern Cape by rating the anti-diabetic activity, mode of action and also highlight their therapeutic potentials based on the available evidence on their pharmacology and toxicity. Forty-five plants mentioned in ethnobotanical surveys were subjected to a comprehensive literature search in the available electronic databases such as PubMed, ScienceDirect, Google Scholar and Elsevier, by using “plant name” and “family” as the keywords for the primary searches to determine the plants that have been scientifically investigated for anti-diabetic activity. The search returned 25 families with Asteraceae highly reported, followed by Asphodelaceae and Alliaceae. Most of the plants have been studied for their anti-diabetic potentials in vivo and/or in vitro, with most of the plants having a higher percentage of insulin release and inhibition against carbohydrate digesting enzymes as compared with insulin mimetic and peripheral glucose uptake. Almost all the investigated plants also inhibit oxidative stress as part of their hypoglycemic activity with less toxicity. However, the isolation of their bioactive molecules is still lacking. This review provides a resource to enable thorough assessments of the therapeutic profiles of available medicinal plants used for the management of diabetes in the Eastern Cape, South Africa. Further studies such as the identification of the active ingredients of potent plants still need to be carried out; this may lead to new molecules in drug discovery and development.

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Ethnoveterinary medicinal plants application for the treatment of tick-borne diseases in cattle around the Eastern Cape Province of South Africa

Journal of Medicinal Plants for Economic Development ◽

10.4102/jomped.v4i1.100 ◽

2020 ◽

Vol 4 (1) ◽

Author(s):

Siza Mthi ◽

Jean Rust ◽

Mandla Yawa ◽

Louis Tyasi

Keyword(s):

South Africa ◽

Medicinal Plants ◽

Eastern Cape Province ◽

Eastern Cape

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The prevalence and perceived efficacy of medicinal plants used for stomach ailments in the Amathole District Municipality, Eastern Cape, South Africa

South African Journal of Botany ◽

10.1016/j.sajb.2016.10.018 ◽

2017 ◽

Vol 108 ◽

pp. 144-148 ◽

Cited By ~ 4

Author(s):

O.A. Wintola ◽

W.M. Otang ◽

A.J. Afolayan

Keyword(s):

South Africa ◽

Medicinal Plants ◽

Eastern Cape ◽

Perceived Efficacy

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Protective effect of astragaloside IV on oxidative damages of Chang Liver cell induced by ethanol and H2O2

China Journal of Chinese Materia Medica ◽

10.4268/cjcmm20142229 ◽

2014 ◽

Keyword(s):

Protective Effect ◽

Liver Cell ◽

Astragaloside Iv ◽

Chang Liver Cell ◽

Oxidative Damages ◽

Chang Liver

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Medicinal Plants Used by the Inhabitants of Alfred Nzo District Municipality in the Eastern Cape Province, South Africa

Journal of Pharmacy and Nutrition Sciences ◽

10.29169/1927-5951.2019.09.03.4 ◽

2019 ◽

Vol 9 (3) ◽

pp. 157-166

Author(s):

Zingisa Thinyane ◽

Alfred Maroyi

Keyword(s):

South Africa ◽

Medicinal Plants ◽

Plant Species ◽

Primary Healthcare ◽

Biological Activities ◽

Herbal Medicines ◽

Pharmaceutical Products ◽

Eastern Cape Province ◽

Eastern Cape ◽

Snowball Sampling

Plant species used as herbal medicines play an important in the provision of primary healthcare in several rural communities. The current study was aimed at documenting medicinal plants used by the inhabitants of Alfred Nzo District Municipality in the Eastern Cape province, South Africa. Information on medicinal plants used for primary healthcare was collected through open-ended interviews with a sample of 124 participants selected via snowball-sampling technique between April 2017 and May 2018. A total of 34 plant species and one fungus species representing 20 families were used in the treatment of 13 different human diseases. The major diseases treated by the documented species included respiratory system, pain, sores and wounds, infections and infestations, digestive system, blood and cardiovascular system, fever and malaria, general ailments, reproductive system and sexual health and mental disorders. Popular herbal medicines with relative frequency citation (RFC) values exceeding 0.50 included Bulbine frutescens, Clivia miniata var. miniata, Elephantorrhiza elephantina, Centella asiatica, Hypoxis hemerocallidea, Dicerothamnus rhinocerotis, Leonotis leonurus, Agapanthus africanus and Datura stramonium. Such repository of medicinal plants and fungi reinforces the need for an evaluation of their biological activities as a basis for developing future medicines and pharmaceutical products.

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