Therapeutic response assessment of high-intensity focused ultrasound (HIFU) ablation for pancreatic cancer: Utility of contrast-enhanced ultrasonography (CEUS)

PURPOSE: To evaluate the feasibility of dynamic contrast enhanced ultrasound (DCE-US) in predicting treatment response of high-intensity focused ultrasound (HIFU) in patients with locally advanced pancreatic cancer (LAPC) lesions. PATIENTS AND METHODS: In this prospective study, 10 patients with pathologically confirmed LAPC lesions (7 men, 3 women; average age, 61.13±5.80 years) were prospectively enrolled. All patients received HIFU treatment with peak intensity at 12000 W/cm2. Contrast enhanced ultrasound (CEUS) was performed with an ACUSON Oxana 2 ultrasound equipment and a 6 C-1 transducer (1–6 Hz). A dose of 2.4 ml SonoVue was injected for each examination. Time intensity curves (TICs) were generated and quantitative analyses were performed by SonoLiver software. B mode ultrasound (BMUS) features, CEUS enhancement patterns, TICs, CEUS quantitative parameters and serum carcinoma antigen 19-9 (CA19-9) levels were compared before and 4 weeks after HIFU treatment. Statistical analyses were performed with SPSS Version 20.0 and GraphPad Prism 5. RESULTS: While comparing before and after HIFU, no significant difference was obtained on mean size of lesion, BMUS or CEUS features. After HIFU treatment, TICs showed decreased and delayed enhancement. Among all CEUS quantitative parameters, significant decrease could be found in maximum intensity (MI) (60.66±23.95% vs 41.31±26.74%) and mean transit time (mTT) (76.66±47.61 s vs 38.42±28.35 s). CA19-9 level decreased significantly after HIFU (2747.92±4237.41 U/ml vs 715.08±1773.90 U/ml) (P = 0.05). CONCLUSION: DCE-US combining with quantitative analysis might be a useful imaging method for early treatment response evaluation of HIFU in LAPC lesions.

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A preliminary clinical study on high-intensity focused ultrasound therapy for tubal pregnancy

Scottish Medical Journal ◽

10.1258/smj.2011.011161 ◽

2011 ◽

Vol 56 (4) ◽

pp. 214-219

Author(s):

G-B He ◽

W Luo ◽

X-D Zhou ◽

L-W Liu ◽

M Yu ◽

...

Keyword(s):

High Intensity ◽

Focused Ultrasound ◽

Tubal Pregnancy ◽

High Intensity Focused Ultrasound ◽

Lesion Volume ◽

Hifu Treatment ◽

Contrast Enhanced ◽

Before And After ◽

Contrast Enhanced Ultrasonography ◽

Β Hcg

Our aim was to explore the clinical application value of high-intensity focused ultrasound (HIFU) therapy for tubal pregnancy. Forty hospitalized patients with tubal pregnancies (28 cases of non-ruptured tubal pregnancy and 12 cases of ruptured tubal pregnancy) were selected to receive HIFU therapy. Serum human chorionic gonadotropin (β-HCG) concentrations were compared before and after treatment. Serum β-HCG was measured weekly and patients received observation only if the concentration decreased by 15% or more, compared with the previous value. Patients were given supplement HIFU therapy if the decrease in the serum β-HCG was <15% within two weeks. Ultrasound was used to detect the volume changes in the ectopic lesions before and after treatment, and changes in vital signs and complications were recorded. Contrast-enhanced ultrasonography was used to assess fallopian tube patency after treatment. HIFU treatment was successful in 33 of the 40 patients (82%). Seven patients failed HIFU treatment and received surgical therapy (18%). Before and after treatment, serum β-HCG concentrations and lesion volume were significantly different ( P < 0.05, P < 0.01, respectively). Post-treatment tubal contrast-enhanced ultrasonography showed tubal patency on the affected side in 21 cases (64%) at six months and in 27 cases (82%) at 12 months. In conclusion, HIFU is safe and effective, and can be a treatment option for tubal pregnancy.

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Contrast-enhanced Ultrasonography Assessment of Therapeutic Efficacy for Ultrasound-guided High-intensity Focused Ultrasound Ablation of Uterine Fibroids: Comparison with Contrast-enhanced Magnetic Resonance

Journal of Medical Ultrasound ◽

10.1016/j.jmu.2013.10.007 ◽

2014 ◽

Vol 22 (1) ◽

pp. 22-28 ◽

Cited By ~ 3

Author(s):

Yang Wang ◽

Wei Wang ◽

Huiyi Ye

Keyword(s):

Magnetic Resonance ◽

High Intensity ◽

Focused Ultrasound ◽

Uterine Fibroids ◽

High Intensity Focused Ultrasound ◽

Ultrasound Guided ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Ultrasound Ablation ◽

Focused Ultrasound Ablation

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Contrast-enhanced ultrasound for evaluating response to pulsed-wave high-intensity focused ultrasound therapy in advanced pancreatic cancer

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211342 ◽

2022 ◽

pp. 1-11

Author(s):

Yu Yang ◽

Xian-quan Shi ◽

Guang Chen ◽

Xiao-na Zhou ◽

Lin-xue Qian

Keyword(s):

Pancreatic Cancer ◽

High Intensity ◽

Focused Ultrasound ◽

Advanced Pancreatic Cancer ◽

High Intensity Focused Ultrasound ◽

Response To Treatment ◽

Contrast Enhanced Ultrasound ◽

Hifu Treatment ◽

Group 4 ◽

Contrast Enhanced

OBJECTIVE: To examine whether contrast-enhanced ultrasound (CEUS) parameters in patients with advanced pancreatic cancer could be used to assess response to treatment with pulsed-wave high intensity focused ultrasound (PW-HIFU). METHODS: We prospectively recorded the pretreatment and posttreatment CEUS related parameters, CA19-9, pain scores of 30 patients with advanced pancreatic cancer treated with PW-HIFU treatment. Correlation of clinical parameters, tumor characteristics, and PW-HIFU treatment energy with CEUS parameters were analyzed. RESULTS: Pain score decreased after treatment (from 4.80±2.14 to 3.28±1.93, p = 0.001). CA19-9 dropped in RT decreased group, 4 weeks after one session PW-HIFU, compared with prolonged group (p = 0.013). According to the display of blood vessels in the mass by CEUS, tumors were classified by vessel grade (VG), VG1: no vessel can be seen; VG 2: vessels diameter < 5 mm; VG 3: vessels diameter > 5 mm. VGs were different between increased and decreased relative rise intensity (rRI) groups (p = 0.008). VG1 group shown a decreased rRI after treatment, while VG3 group showed the opposite trend (p = 0.006). CONCLUSIONS: CEUS can evaluating response to PW-HIFU in advanced pancreatic cancer. Quantitative analysis may help to assess the short-term efficacy of patients and help for individualized treatment.

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