Non-invasive fetal platelet and red cell blood group genotyping with the use of targeted massively parallel sequencing of maternal plasma cell-free DNA

2016 ◽  
Vol 76 (10) ◽  
Author(s):  
S Wienzek-Lischka ◽  
J Dehl ◽  
A Krautwurst ◽  
V Fröhner ◽  
H Hackstein ◽  
...  
Keyword(s):  
Blood Group ◽  
Plasma Cell ◽  
Massively Parallel Sequencing ◽  
Maternal Plasma ◽  
Massively Parallel ◽  
Red Cell ◽  
Cell Free Dna ◽  
Parallel Sequencing ◽  
Non Invasive ◽  
Free Dna

scholarly journals The fragmentation patterns of maternal plasma cell‐free DNA and its applications in non‐invasive prenatal testing

2020 ◽  
Vol 40 (8) ◽  
pp. 911-917 ◽  
Author(s):  
Min Pan ◽  
Pingsheng Chen ◽  
Jiafeng Lu ◽  
Zhiyu Liu ◽  
Erteng Jia ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Prenatal Testing ◽  
Maternal Plasma ◽  
Cell Free Dna ◽  
Non Invasive ◽  
Free Dna ◽  
Fragmentation Patterns

430 Epigenetic cell-free DNA biomarkers of prostate cancer: The search by massively parallel sequencing

2015 ◽  
Vol 51 ◽  
pp. S88
Author(s):  
A. Bondar ◽  
A. Kurilshikov ◽  
E. Morozkin ◽  
M. Zaripov ◽  
M. Kabilov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Massively Parallel Sequencing ◽  
Massively Parallel ◽  
Cell Free Dna ◽  
Parallel Sequencing ◽  
Free Dna

scholarly journals Non-invasive prenatal diagnosis by massively parallel sequencing of maternal plasma DNA

Open Biology ◽  
2012 ◽  
Vol 2 (6) ◽  
pp. 120086 ◽  
Author(s):  
Yuk Ming Dennis Lo
Keyword(s):  
Prenatal Diagnosis ◽  
Massively Parallel Sequencing ◽  
Maternal Plasma ◽  
Massively Parallel ◽  
Plasma Dna ◽  
Parallel Sequencing ◽  
Non Invasive ◽  
Prenatal Detection ◽  
A Genome ◽  
Chromosomal Aneuploidies

The presence of foetal DNA in the plasma of pregnant women has opened up new possibilities for non-invasive prenatal diagnosis. The use of circulating foetal DNA for the non-invasive prenatal detection of foetal chromosomal aneuploidies is challenging as foetal DNA represents a minor fraction of maternal plasma DNA. In 2007, it was shown that single molecule counting methods would allow the detection of the presence of a trisomic foetus, as long as enough molecules were counted. With the advent of massively parallel sequencing, millions or billions of DNA molecules can be readily counted. Using massively parallel sequencing, foetal trisomies 21, 13 and 18 have been detected from maternal plasma. Recently, large-scale clinical studies have validated the robustness of this approach for the prenatal detection of foetal chromosomal aneuploidies. A proof-of-concept study has also shown that a genome-wide genetic and mutational map of a foetus can be constructed from the maternal plasma DNA sequencing data. These developments suggest that the analysis of foetal DNA in maternal plasma would play an increasingly important role in future obstetrics practice. It is thus a priority that the ethical, social and legal issues regarding this technology be systematically studied.

Massively parallel sequencing of cell-free DNA enriched from a single drop of urine.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e23189-e23189
Author(s):  
Chen-Hsiung Yeh ◽  
Andrew Ford ◽  
Jonathan Spurgin ◽  
Ashlee Stamba ◽  
James Posey
Keyword(s):  
Massively Parallel Sequencing ◽  
Massively Parallel ◽  
Single Drop ◽  
Cell Free Dna ◽  
Parallel Sequencing ◽  
Free Dna
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