Can obliquumol isolated from Ptaeroxylon obliquum be a new framework molecule for future antifungal antibiotics?

Universities have long recognized the need to create pathways for ideas and new technologies to advance from academic labs to market; however, the decentralized and haphazard nature of American innovation means that some discoveries may be neglected. In order to more effectively address the issues with innovation, a research team led by Steven Currall produced a new framework in the book Organized Innovation: A Blueprint for Renewing America's Prosperity. Because of the current drive of universities to increase innovation, economic development, and corporate partnerships, we thought it was timely to revisit this book and offer commentary on its lessons for navigating these demands.

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A New Framework for Industrial Cooperation between Korea and the EAEU

SSRN Electronic Journal ◽

10.2139/ssrn.3304929 ◽

2018 ◽

Author(s):

Joungho Park ◽

Dongho Yeom ◽

Boogyun Kang ◽

Jiyoung Min ◽

ChiHyun Yun

Keyword(s):

Industrial Cooperation ◽

New Framework

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A New Framework for Foreign Exchange Risk Management in the Canadian Department of National Defence

SSRN Electronic Journal ◽

10.2139/ssrn.419561 ◽

2003 ◽

Author(s):

Christopher H. Bucar ◽

Naceur Essaddam ◽

Richard Groves

Keyword(s):

Risk Management ◽

Foreign Exchange ◽

Foreign Exchange Risk ◽

Exchange Risk ◽

Department Of National Defence ◽

National Defence ◽

New Framework ◽

Canadian Department ◽

Exchange Risk Management

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Strategic planning in today's dynamic world

Water Science & Technology Water Supply ◽

10.2166/ws.2005.0022 ◽

2005 ◽

Vol 5 (2) ◽

pp. 53-62

Author(s):

Terrance M. Brueck

Keyword(s):

Strategic Planning ◽

Cause And Effect ◽

Security Issues ◽

Strategic Plans ◽

Planning Framework ◽

The Subject ◽

New Framework

Utilities today must adapt quickly to complex changes in workforce, infrastructure, technology, and regulations, as well as outside factors of the economy, security issues, and societal trends. Linear, cause-and-effect strategic planning does not work well in today's world. Given these uncertainties, how can utilities develop meaningful and useful strategic plans? Faced with these challenges, a group of 18 leading international utilities, assisted through IWA, has developed new ways of strategic planning. This project, sponsored by AwwaRF and conducted by EMA, has created a dynamic and flexible strategic planning framework. A new framework, coupled with many of these utilities' experiences in strategic planning, is the subject of this paper.

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Design and synthesis of new antifungals based on N- un-substituted azoles as 14α demethylase inhibitor

Current Computer - Aided Drug Design ◽

10.2174/1573409916666200217090855 ◽

2020 ◽

Vol 16 ◽

Author(s):

Asghar Davood ◽

Aneseh Rahimi ◽

Maryam Iman ◽

Parisa Azerang ◽

Soroush Sardari ◽

...

Keyword(s):

Antimicrobial Agents ◽

Antifungal Agents ◽

Molecular Design ◽

Pathogenic Fungi ◽

Antimicrobial Activities ◽

Docking Studies ◽

Receptor Interaction ◽

Main Role ◽

Design And Synthesis ◽

Antifungal Antibiotics

Objective(s): Azole antifungal agents, which are widely used as antifungal antibiotics, inhibit cytochrome P450 sterol 14α-demethylase (CYP51). Nearly all azole antifungal agents are N-substituted azoles. In addition, an azolylphenalkyl pharmacophore is uniquely shared by all azole antifungals. Due to importance of nitrogen atom of azoles (N-3 of imidazole and N-4 of triazole) in coordination with heme in the binding site of the enzyme, here a group of N- un-substituted azoles in which both of nitrogen is un-substituted was reported. Materials and Methods: Designed compounds were synthesized by reaction of imidazole-4-carboxaldehyde with appropriate arylamines and subsequently reduced to desired amine derivatives. Antifungal activity against Candida albicans and Saccharomyces cervisiae were done using a broth micro-dilution assay. Docking studies were done using AutoDock. Results: Antimicrobial evaluation revealed that some of these compounds exhibited moderate antimicrobial activities against tested pathogenic fungi, wherein compound 3, 7 and 8 were potent. Docking studies propose that all of the prepared azoles interacted with 14α-DM, wherein azole-heme coordination play main role in drug-receptor interaction. Conclusion: Our results offer some useful references in order to molecular design performance or modification of this series of compounds as a lead compound to discover new and potent antimicrobial agents.

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The Art of Improvisation and Street-Level Bureaucracy

Public Voices ◽

10.22140/pv.86 ◽

2016 ◽

Vol 12 (2) ◽

pp. 68

Author(s):

Lauren Bock Mullins

Keyword(s):

Bureaucratic Discretion ◽

Street Level ◽

Similarities And Differences ◽

New Framework ◽

Street Level Bureaucracy

This article explores the similarities and differences between the art of improvisation and street-level bureaucracy. By offering a new framework that points out the similarities between bureaucratic discretion and improvisation, we see how street-level bureaucracy has artistic elements, which can be helpful in expanding our understanding of this phenomenon.

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