Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction

Synlett ◽  
2018 ◽  
Vol 29 (16) ◽  
pp. 2199-2202 ◽  
Author(s):  
Chuan Xu ◽  
Zhong-Zhu Chen ◽  
Zhi-Gang Xu ◽  
Yong Ding ◽  
Jiang-Ping Meng ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Cascade Reaction ◽  
Cyclization Reaction ◽  
Reaction Sequence ◽  
One Pot ◽  
Microwave Assisted ◽  
Small Series ◽  
Leaving Group

A small series of hydantoins was efficiently synthesized via a two-step Ugi/cyclization reaction sequence using alkyne group as a leaving group under basic conditions. This microwave-assisted one-pot cyclization strategy could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like hydantoins.

Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

Synthesis ◽  
2020 ◽  
Author(s):  
Guolin Zhang ◽  
Yongping Yu ◽  
Zijuan Wang ◽  
Wenteng Chen ◽  
Chang He
Keyword(s):  
Bond Formation ◽  
Cascade Reaction ◽  
Cyclization Reaction ◽  
One Pot ◽  
Tandem Cyclization ◽  
The One

AbstractA one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed­ cascade reaction involving C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator­ protein (TSPO) ligand.

scholarly journals Cyclization reaction of amines with dialkyl carbonates to yield 1,3-oxazinan-2-ones

2011 ◽  
Vol 84 (3) ◽  
pp. 707-719 ◽  
Author(s):  
C. Robert McElroy ◽  
Fabio Aricò ◽  
Franco Benetollo ◽  
Pietro Tundo
Keyword(s):  
Primary Amine ◽  
Good Yield ◽  
Time Span ◽  
Cyclization Reaction ◽  
One Pot ◽  
Dialkyl Carbonates ◽  
Short Time Span ◽  
Leaving Group ◽  
Reaction Proceeds ◽  
Short Time

A number of six-membered cyclic carbamates (oxazinanones) were synthesized from the reaction of a primary amine or hydrazine with a dicarbonate derivative of 1,3-diols in a one-pot reaction, in good yield, short time span, and in the absence of a solvent. The reaction proceeds in two steps: an intermolecular reaction to give a linear intermediate and an intramolecular cyclization to yield the cyclic carbamate. This is the first example of a carbonate reacting selectively and sequentially, firstly at the carbonyl center to form a linear carbamate and then as a leaving group to yield a cyclic carbamate.

scholarly journals Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction

2020 ◽  
Vol 16 ◽  
pp. 663-669
Author(s):  
Yong Li ◽  
Zheng Huang ◽  
Jia Xu ◽  
Yong Ding ◽  
Dian-Yong Tang ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Cascade Reaction ◽  
Synthetic Methods ◽  
Tetramic Acid ◽  
Facile Synthesis ◽  
One Pot ◽  
Simple Operation ◽  
Microwave Assisted ◽  
Broad Scope ◽  
Microwave Assisted Method

A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogues in good yields. With commercially available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogues, which cannot be easily accessed by the classic synthetic methods.

scholarly journals A new class of fluorogenic thiazolo[2,3-b]quinazolinone receptor: selective detection towards mercury and hydrogen bisulfate ions in aqueous medium

RSC Advances ◽  
2021 ◽  
Vol 11 (53) ◽  
pp. 33288-33293
Author(s):  
Prajna Parimita Mohanta ◽  
Aparna Prabha Devi ◽  
Bhawani Prasad Bag ◽  
Hari Narayan Pati ◽  
Ajaya Kumar Behera
Keyword(s):  
Aqueous Medium ◽  
Cascade Reaction ◽  
Selective Detection ◽  
One Pot ◽  
Structural Arrangement ◽  
New Class ◽  
Microwave Assisted

Fluorophoric thiazoloquinazoline derivatives were synthesized under microwave assisted one-pot three-component cascade reaction. Owing to their unique structural arrangement, a new bioactive molecular receptor was developed for HSO4− and Hg2+ ions.

Identification of novel imidazoles as IDO1 inhibitors through microwave‐assisted one‐pot multicomponent reactions

2019 ◽  
Vol 352 (11) ◽  
pp. 1900165 ◽  
Author(s):  
Zhizheng Bai ◽  
Huidan Huang ◽  
Jianqiu Chen ◽  
Xiaoyun Zhang ◽  
Yimei Ding
Keyword(s):  
Multicomponent Reactions ◽  
One Pot ◽  
Microwave Assisted

Microwave-assisted one-pot synthesis of pyrimido［4,5-b］quinolines derivatives

2013 ◽  
Vol 30 (6) ◽  
pp. 636-642
Author(s):  
Xueli Zhang ◽  
Zhilan Lin ◽  
Huiling Hu ◽  
Jiaxin He ◽  
Yuan Gao
Keyword(s):  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis
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