Relevance of chromosome 13 aberrations in canine tumours

2012 ◽  
Vol 40 (04) ◽  
pp. 267-270 ◽  
Author(s):  
H. Escobar ◽  
I. Nolte ◽  
N. Reimann-Berg
Keyword(s):  
Chromosome Aberrations ◽  
Human Chromosomes ◽  
High Homology ◽  
Chromosome 13 ◽  
Human Tumours ◽  
Cytogenetic Studies ◽  
Canine Chromosome ◽  
Chromosomal Changes

SummaryFor human tumours there are many reports documenting the correlation between chromosome aberrations and tumour entities. Due to the complex canine karyotypic pattern (78 chromosomes), cytogenetic studies of tumours of the dog are rare. However, the reports in the literature show, that canine chromosome 13 (CFA 13) is predominantly involved in chromosomal changes. Interestingly, CFA 13 shows high homology to regions on the human chromosomes 4 (HSA 4) and 8 (HSA 8), which harbour the proto-oncogenes c-KIT and c-MYC. Both of these genes are involved in the development and progression of some human and canine tumour diseases.

Chronic. Myeloid Leukemia with Monoclonal Gammopathy Terminating in Myeloid Crisis and Immunoblastic Lymphoma

1989 ◽  
Vol 75 (2) ◽  
pp. 106-109
Author(s):  
Luigi M. Larocca ◽  
Marcella Zollino ◽  
Arnaldo Carbone ◽  
Maria Luisa Eboli ◽  
Giorgio Mango ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Monoclonal Gammopathy ◽  
Myeloid Leukemia ◽  
Blast Crisis ◽  
Chromosome Abnormalities ◽  
Immunoblastic Lymphoma ◽  
Cytogenetic Studies ◽  
Ph Chromosome ◽  
Chromosomal Changes ◽  
Complex Chromosome

A patient, with chronic myeloid leukemia and IgA monoclonal gammopathy, who contemporaneously developed myeloid blast crisis and immunoblastic lymphoma is reported. Cytogenetic studies showed complex chromosome abnormalities concerning chromosomes 8, 14 and 22, other than the Ph chromosome. A possible relationship between the emergence of immunoblasts from slow proliferating lymphoplasmacytoid cells, myeloid blasts crisis and chromosomal changes is discussed.

scholarly journals Charles Edmund Ford. 24 October 1912 – 7 January 1999

2001 ◽  
Vol 47 ◽  
pp. 189-201 ◽  
Author(s):  
Mary F. Lyon
Keyword(s):  
Chromosome Aberrations ◽  
Scientific Method ◽  
Mammalian Cells ◽  
Human Chromosomes ◽  
Cell Lineages ◽  
Human Cytogenetics ◽  
Equal Importance ◽  
Mammalian Genetics ◽  
The 1960S ◽  
Haemopoietic Cells

Charles Edmund Ford was distinguished for his outstanding contributions to mammalian cytogenetics, particularly human cytogenetics. He was especially renowned for his part in establishing the number of human chromosomes as 46, rather than 48 as previously believed. However, his contributions to the use of chromosome variants as cell markers in tracing cell lineages, particularly of haemopoietic cells, were of equal importance. He had a great mastery of cytological techniques and his ability to devise suitable methods for mammalian cells was a major factor in his contribution to the explosive advance of human and other mammalian genetics in the 1960s. Equally important were his superb observational powers in interpreting chromosome aberrations under the microscope, and his scrupulous adherence to scientific method.

A novel locus on canine chromosome 13 is associated with cataract in the Australian Shepherd breed of domestic dog

2015 ◽  
Vol 26 (5-6) ◽  
pp. 257-263 ◽  
Author(s):  
Sally L. Ricketts ◽  
Louise Pettitt ◽  
Bryan McLaughlin ◽  
Christopher A. Jenkins ◽  
Cathryn S. Mellersh
Keyword(s):  
Domestic Dog ◽  
Chromosome 13 ◽  
Canine Chromosome

IDENTIFICATION AND NOMENCLATURE FOR G-BANDED BOVINE CHROMOSOMES

1977 ◽  
Vol 19 (2) ◽  
pp. 271-282 ◽  
Author(s):  
C. C. Lin ◽  
D. R. Newton ◽  
R. B. Church
Keyword(s):  
Chromosome Aberrations ◽  
Bovine Chromosome ◽  
Banding Technique ◽  
Human Chromosomes ◽  
Giemsa Banding ◽  
Unequivocal Identification

A reliable trypsin-Giemsa banding technique for producing clearly differentiated G-bands on bovine chromosomes was introduced. Unequivocal identification of individual bovine chromosome pairs is now possible. A system similar to the standardization of human chromosomes was proposed for the nomenclature of the G-bands. This scheme of nomenclature will facilitate the identification and recording of chromosome aberrations in this species.

Unusual Chromosomal Rearrangement Resulted in Interstitial Monosomy 9p: Case Report

2016 ◽  
Vol 148 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Ceren D. Durmaz ◽  
Kanay Yararbaş ◽  
Nüket Y. Kutlay ◽  
Özlem Türedi ◽  
İsmigül Akın ◽  
...  
Keyword(s):  
Case Report ◽  
Congenital Malformations ◽  
Chromosomal Rearrangement ◽  
De Novo ◽  
Psychomotor Development ◽  
Molecular Karyotyping ◽  
Fish Analysis ◽  
Chromosome 13 ◽  
Craniofacial Dysmorphism ◽  
Cytogenetic Studies

We report on a 4.5-year-old boy with interstitial monosomy 9p in a unique and complex de novo rearrangement. The patient had been referred for craniofacial dysmorphism, delayed psychomotor development, and various congenital malformations. We combined cytogenetic studies and FISH analyses to delineate the deletion. The result of our cytogenetic studies was 46,XY,der(9)(p22pter). In order to confirm the deletion, we also performed FISH analysis, which showed that the 9p subtelomeric region was inserted into chromosome 13. Molecular karyotyping was performed to describe the exact genomic breakpoints of the rearrangement. In conclusion, this case is a complex insertion/deletion abnormality which has not been reported before.

scholarly journals Non-Random Mis-Segregation of Human Chromosomes

2018 ◽  
Author(s):  
J. T. Worrall ◽  
N. Tamura ◽  
N. Shaikh ◽  
A. Mazzagatti ◽  
T. van Lingen ◽  
...  
Keyword(s):  
Single Cell ◽  
High Throughput ◽  
Single Cell Analysis ◽  
Human Chromosomes ◽  
High Throughput Analysis ◽  
Selection Processes ◽  
Equal Chance ◽  
Chromosomal Changes ◽  
Technological Limitations ◽  
Recurrent Patterns

SummaryRecurrent patterns of chromosomal changes (aneuploidy) are widespread in cancer. These patterns are mainly attributed to selection processes due to an assumption that human chromosomes carry equal chance of being mis-segregated into daughter cells when fidelity of cell division is compromised. Human chromosomes vary widely in size, gene density and other parameters that might generate bias in mis-segregation rates, however technological limitations have precluded a systematic and high throughput analysis of chromosome-specific aneuploidy. Here, using fluorescence In-Situ hybridization (FISH) imaging of specific centromeres coupled with high-throughput single cell analysis, as well as single-cell sequencing we show that human chromosome mis-segregation is non-random. Merotelic kinetochore attachment induced by nocodazole washout leads to elevated aneuploidy of a subset of chromosomes, and high rates of anaphase lagging of chromosomes 1 and 2. Mechanistically, we show that these chromosomes are prone to cohesion fatigue that results in anaphase lagging upon release from nocodazole or Eg5 inhibition. Our findings suggest that inherent properties of specific chromosomes can influence chromosome mis-segregation and aneuploidy, with implications for studies on aneuploidy in human disease.

Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome 13 linked to beige (bg) and identifies a new region of homology between mouse and human chromosomes

Genomics ◽  
1991 ◽  
Vol 9 (2) ◽  
pp. 401-403 ◽  
Author(s):  
Nancy A. Jenkins ◽  
Monica J. Justice ◽  
Debra J. Gilbert ◽  
Mon-Li Chu ◽  
Neal G. Copeland
Keyword(s):  
Mouse Chromosome ◽  
Human Chromosomes ◽  
Chromosome 13
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