scholarly journals Charles Edmund Ford. 24 October 1912 – 7 January 1999

2001 ◽  
Vol 47 ◽  
pp. 189-201 ◽  
Author(s):  
Mary F. Lyon

Charles Edmund Ford was distinguished for his outstanding contributions to mammalian cytogenetics, particularly human cytogenetics. He was especially renowned for his part in establishing the number of human chromosomes as 46, rather than 48 as previously believed. However, his contributions to the use of chromosome variants as cell markers in tracing cell lineages, particularly of haemopoietic cells, were of equal importance. He had a great mastery of cytological techniques and his ability to devise suitable methods for mammalian cells was a major factor in his contribution to the explosive advance of human and other mammalian genetics in the 1960s. Equally important were his superb observational powers in interpreting chromosome aberrations under the microscope, and his scrupulous adherence to scientific method.

2012 ◽  
Vol 40 (04) ◽  
pp. 267-270 ◽  
Author(s):  
H. Escobar ◽  
I. Nolte ◽  
N. Reimann-Berg

SummaryFor human tumours there are many reports documenting the correlation between chromosome aberrations and tumour entities. Due to the complex canine karyotypic pattern (78 chromosomes), cytogenetic studies of tumours of the dog are rare. However, the reports in the literature show, that canine chromosome 13 (CFA 13) is predominantly involved in chromosomal changes. Interestingly, CFA 13 shows high homology to regions on the human chromosomes 4 (HSA 4) and 8 (HSA 8), which harbour the proto-oncogenes c-KIT and c-MYC. Both of these genes are involved in the development and progression of some human and canine tumour diseases.


2016 ◽  
Vol 60 (4) ◽  
pp. 534-556 ◽  
Author(s):  
Ema Hrešanová

This paper explores the history of the ‘psychoprophylactic method of painless childbirth’ in socialist Czechoslovakia, in particular, in the Czech and Moravian regions of the country, showing that it substantially differs from the course that the method took in other countries. This non-pharmacological method of pain relief originated in the USSR and became well known as the Lamaze method in western English-speaking countries. Use of the method in Czechoslovakia, however, followed a very different path from both the West, where its use was refined mainly outside the biomedical frame, and the USSR, where it ceased to be pursued as a scientific method in the 1950s after Stalin’s death. The method was imported to Czechoslovakia in the early 1950s and it was politically promoted as Soviet science’s gift to women. In the 1960s the method became widespread in practice but research on it diminished and, in the 1970s, its use declined too. However, in the 1980s, in the last decade of the Communist regime, the method resurfaced in the pages of Czechoslovak medical journals and underwent an exciting renaissance, having been reintroduced by a few enthusiastic individuals, most of them women. This article explores the background to the renewed interest in the method while providing insight into the wider social and political context that shaped socialist maternity and birth care in different periods.


1980 ◽  
Vol 208 (1171) ◽  
pp. 121-133 ◽  

Cancers are clones of abnormal cells, arising presumably as the result of mutational or epigenetic alterations of gene expression. The kinetics of appearance of spontaneous cancers in populations of multiplying cells (i. e. the relation between age and cancer incidence) will therefore depend, among other things, on how these populations are organized and, in general, on the kinetics of the response of cells to prolonged mutagenesis. The organization of cell renewal in epithelia (i. e. the arrangement of cell lineages) is still rather obscure; in particular, it is not known to what extent the properties and organization of the stem cells tend to protect them from accumulating mutations. We have tried to mimic the arrangement of epithelia by attaching multiplying bacteria to filters. Study of mutagenesis in long-term cultures of such anchored bacteria has led to the discovery of some additional pathways for DNA repair which also appear to operate in mammalian cells.


Author(s):  
Mike Nellis

Since its operational beginnings in the United States in 1982—where its prototypes were first experimented with in the 1960s and 1970s—the electronic monitoring (EM) of offenders has spread to approximately 40 countries around the world, ostensibly—but not often effectively—to reduce the use of imprisonment by making bail, community supervision, and release from prison more controlling than they have hitherto been. No single authority monitors the development of EM around the world, and it is difficult to gain fully comprehensive accounts of what is happening outside the Western and Anglophone users of it. Some countries are secretive. Standpoints in writing on EM are varied and partisan. Although it still tends to be the pacesetter of technical innovation, the United States remains a relatively lower user of EM, in part because the exceptional punitiveness of its penal culture has inhibited its expansion, even when it has itself been developed in various punitive ways. Interprofessional and intergovernmental processes of “policy transfer” have contributed to EMs spreading around the world, but the commercial bodies that manufacture and market EM equipment have been of at least equal importance. In Europe, the Confederation of European Probation (CEP), a transnational probation advocacy organization, took an early interest in EM, and its regular conferences became a touchstone of international debate. As it developed globally, the United Nations reluctantly accepted that it may be of some value even in developing countries and set out standards for its use. Continuing innovations in EM technology will create new possibilities for offender supervision, both more and less punitive, but it is always culture, commerce, and politics in particular jurisdictions which shape the scale, pace, and form of its development.


2019 ◽  
Vol 12 (570) ◽  
pp. eaav5183 ◽  
Author(s):  
Rik Derynck ◽  
Erine H. Budi

Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if not all, cell lineages and many aspects of cell and tissue physiology in multicellular eukaryotes. Deregulation of TGF-β family signaling leads to developmental anomalies and disease, whereas enhanced TGF-β signaling contributes to cancer and fibrosis. Here, we review the fundamentals of the signaling mechanisms that are initiated upon TGF-β ligand binding to its cell surface receptors and the dependence of the signaling responses on input from and cooperation with other signaling pathways. We discuss how cells exquisitely control the functional presentation and activation of heteromeric receptor complexes of transmembrane, dual-specificity kinases and, thus, define their context-dependent responsiveness to ligands. We also introduce the mechanisms through which proteins called Smads act as intracellular effectors of ligand-induced gene expression responses and show that the specificity and impressive versatility of Smad signaling depend on cross-talk from other pathways. Last, we discuss how non-Smad signaling mechanisms, initiated by distinct ligand-activated receptor complexes, complement Smad signaling and thus contribute to cellular responses.


2018 ◽  
Vol 22 (4) ◽  
pp. 371-384
Author(s):  
Alona Martínez Pérez ◽  
Stephen Walker

This article brings together two distinct aspects of Aldo Rossi's urban theory and reads them against recent urban peripheral development in Madrid. By exploring the scientific method used in Rossi's work The Architecture of the City against the contemporary conditions of this metropolis, the authors examine whether and to what extent either ‘memory’ or ‘permanence’ are reflected in this new city. Additionally, the analogous city of fragments that Rossi explored in the second phase of his career is also brought into play, and considered in relation to Rossi's scientific method. Developing from Rossi's later approach, we carried out a photographic survey of these areas to understand the contemporary urban landscape. We utilise these two theoretical positions in his work as a form of critique on today's periphery, focusing on two of the Urban Action Plans (PAUs) — Las Tablas and San Chinarro — in the city of Madrid, and bridging the ideas of theory and project that were so important for La Tendenza, the group of architects to which Rossi belonged in the 1960s. These specific study areas allow a broader understanding of the patterns of urban development around Madrid, and the consequences of these projects as experienced by citizens of the city. More broadly, this analysis aims to further our understanding of the European urban peripheral condition, and points to the continuing relevance offered by the theoretical approaches of Rossi's work in today's context, a critical discourse that is felt to be necessary by the authors.


Sign in / Sign up

Export Citation Format

Share Document