The Relationship between Blood Coagulation and Thrombosis and Atherosclerosis in Man, Monkeys and Carnivores

1974 ◽  
Vol 31 (01) ◽  
pp. 103-118 ◽  
Author(s):  
Christine M Hawkey
Keyword(s):  
Cardiovascular Disease ◽  
Blood Coagulation ◽  
Animal Species ◽  
Average Rate ◽  
Human Species ◽  
Coagulation Mechanism ◽  
Comparative Survey ◽  
The Relationship ◽  
Blood Coagulation Mechanism ◽  
Increased Susceptibility

SummaryA comparative survey of the blood coagulation mechanism has been carried out in man, non-human primates and carnivores. In man, the average rate of conversion of fibrinogen to fibrin by thrombin is slightly faster and the ability of plasma to neutralise thrombin is less than in the animal species. Otherwise, in general, the activity of the clotting mechanism in monkeys and carnivores is equal to or greater than that of man. These results do not explain the increased susceptibility to spontaneous cardiovascular disease seen in the human species.

THE BLOOD COAGULATION MECHANISM OF FROGS, WITH RESPECT TO THE SPECIES SPECIFICITY OF THROMBO PLASTIN, TO INTRACARDIAL THROMBIN INJECTION, AND TO THE EFFECT OF SEASONAL CHANGES

1952 ◽  
Vol 30 (5) ◽  
pp. 420-424
Author(s):  
John J. Spitzer ◽  
Judy A. Spitzer
Keyword(s):  
Prothrombin Time ◽  
Blood Coagulation ◽  
Seasonal Changes ◽  
Thrombin Injection ◽  
Clotting Time ◽  
Coagulation Time ◽  
Coagulation Mechanism ◽  
Significant Difference ◽  
Whole Blood Coagulation Time ◽  
Blood Coagulation Mechanism

1. The prothrombin time of frogs is much shorter using frog rather than rabbit thromboplastin in the determination. The contrary is true for dogs, rabbits, and rats. In guinea pigs there was no significant difference between the two kinds of thromboplastin. 2. The intracardiai injection of thrombin in frogs induces a triphasic response regarding the whole blood coagulation time: (a) shortening, (b) prolongation, and (c) return towards the normal. The return is quicker than in the case of mammals. 3. The following seasonal changes were obtained in “winter” frogs as compared to “summer” animals: (a) pro longed clotting time, (b) increased prothrombin time, and (c) lessened effectiveness of intracardiai thrombin solution. The clotting time with added thrombin was not changed.

Evaluation of the blood coagulation mechanism and platelet aggregation in individuals with mechanical or biological heart prostheses

2002 ◽  
Vol 13 (2) ◽  
pp. 129-134 ◽  
Author(s):  
C. N. Ferreira ◽  
L. M. Vieira ◽  
L. M. S. Dusse ◽  
C. V. Reis ◽  
C. F. S. Amaral ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Blood Coagulation ◽  
Coagulation Mechanism ◽  
Blood Coagulation Mechanism

Alterations in blood coagulation mechanism after incompatible blood transfusion

1955 ◽  
Vol 89 (3) ◽  
pp. 583-592 ◽  
Author(s):  
Donald G. McKay ◽  
Robert M. Hardaway ◽  
G.H. Wahle ◽  
Richard Edelstein ◽  
Donald E. Tartock
Keyword(s):  
Blood Transfusion ◽  
Blood Coagulation ◽  
Coagulation Mechanism ◽  
Blood Coagulation Mechanism

Investigation on Carbohydrate Residues Involved in the Blood Coagulation Mechanism Using Lectins

1979 ◽  
Author(s):  
H.J. Klein ◽  
E. Wenzel ◽  
B. Podolsak
Keyword(s):  
Blood Coagulation ◽  
Room Temperature ◽  
Coagulation Factors ◽  
Inhibitory Influence ◽  
Blood Coagulation Factors ◽  
Clotting System ◽  
Global Test ◽  
Coagulation Mechanism ◽  
Strongly Connected ◽  
Blood Coagulation Mechanism

Decline in the activity of blood coagulation factors of titrated pooled human plasma (in%) after incubation with lectins (final concentration 1mg/ml, 15 min.at room temperature):The inhibitory influence of lectins could be prevented by adding specific carbohydrates. Taking the specificity of lectins into account, one could assume that carbohydrate residue Ac-D-gluc. has a prominent influence on clotting activity of FXII and VIII.F-v-activity also seems to be strongly connected with glucosyl or mannosyl residues. Also PTT, as global test for the “intrinsic clotting system” was remarkably prolonged(6x)with WGL (not shown on the table).It is striking that FVII activity is not inhibited by the lectins examined. This raises the question, whether carbon.resid.take part in”extrinsic clotting” at all.

Interference in localization of I131 fibrinogen in rat tumors by anticoagulants

1964 ◽  
Vol 206 (3) ◽  
pp. 573-579 ◽  
Author(s):  
Joseph R. Shaeffer
Keyword(s):  
Blood Coagulation ◽  
Intravenous Injection ◽  
Experimental Period ◽  
Tumor Localization ◽  
Transplantable Tumor ◽  
Specific Tumor ◽  
Coagulation Mechanism ◽  
Liver And Kidney ◽  
Rat Tumors ◽  
Blood Coagulation Mechanism

A transplantable tumor of the rat, the Murphy-Sturm lymphosarcoma, was found to contain 15–25% of the administered radioactive dose 18 hr after intravenous injection of I131-labeled rat fibrinogen in a rat bearing a tumor in the 2–12 g wt. range. At this time the concentration of radioactivity per gram of tumor was found to be some 4–15 times that of such vascular organs as the liver and kidney, smaller tumors (2–5 g) localizing much more of the injected radioactive dose per gram than larger tumors (8–12 g). These tumors did not concentrate radioactivity after intravenous injection of either I131 γ-globulin or inorganic NaI131. The administration of heparin or warfarin in dosages adequate to completely inhibit the blood coagulation mechanism throughout the 18-hr experimental period decreased this specific tumor localization of I131 fibrinogen by 60–80%. It is concluded that the effect of heparin and warfarin on the coagulation mechanism is probably responsible for this decrease. A possible mechanism of tumor localization of I131 fibrinogen is discussed.

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