Besser als Genexpressionstests?

Onkologische Welt ◽

10.1055/s-0038-1649303 ◽

2018 ◽

Vol 09 (02) ◽

pp. 65-66

Author(s):

Alexander Kretzschmar

Keyword(s):

New York ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Proof Of Concept ◽

Zirkulierende Tumorzellen

Zirkulierende Tumorzellen (Circulating Tumor Cells; CTC) sind Prädiktoren von Spät-rezidiven bei Frauen mit einem Hormonrezeptor-positiven (HR-positiv), HER2-negativen frühen Mammakarzinom. Dies ergab eine Proof-of-Concept-Studie, die von Dr. Joseph Sparano, New York, auf dem SABCS 2017 vorgestellt wurde. Spätrezidive machen etwa die Hälfte aller Östrogenrezeptor-positiven Rezidive aus. Genexpressionstests können zwar das Risiko eines Rezidivs insgesamt quantifizieren. Sparanos Arbeitsgruppe glaubt aber, dass CTC bessere Biomarker für Spätrezidive sind.

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Final results of a multicenter phase II clinical trial evaluating the activity of single-agent lapatinib in patients with HER2-negative metastatic breast cancer and HER2-positive circulating tumor cells. A proof-of-concept study

Breast Cancer Research and Treatment ◽

10.1007/s10549-012-2045-1 ◽

2012 ◽

Vol 134 (1) ◽

pp. 283-289 ◽

Author(s):

Marta Pestrin ◽

Silvia Bessi ◽

Fabio Puglisi ◽

Alessandro M. Minisini ◽

Giovanna Masci ◽

...

Keyword(s):

Breast Cancer ◽

Clinical Trial ◽

Metastatic Breast Cancer ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Single Agent ◽

Metastatic Breast ◽

Proof Of Concept ◽

Her2 Positive ◽

Multicenter Phase

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Abstract P6-10-27: The clinical utility of mutations detected on circulating tumor cells: A proof of concept study based on a metastasized breast cancer index patient

10.1158/1538-7445.sabcs19-p6-10-27 ◽

2020 ◽

Author(s):

André Franken ◽

Bianca Behrens ◽

Florian Reinhardt ◽

Liwen Yang ◽

Mahdi Rivandi ◽

...

Keyword(s):

Breast Cancer ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Clinical Utility ◽

Index Patient ◽

Proof Of Concept ◽

Concept Study ◽

Breast Cancer Index

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The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study

PLoS ONE ◽

10.1371/journal.pone.0062543 ◽

2013 ◽

Vol 8 (5) ◽

pp. e62543 ◽

Author(s):

Justin Stebbing ◽

Rachel Payne ◽

Justine Reise ◽

Adam E. Frampton ◽

Miranda Avery ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Metastatic Breast ◽

Proof Of Concept ◽

Primary Tumors ◽

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The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes - A Proof-of-Concept Study

PLoS ONE ◽

10.1371/journal.pone.0158354 ◽

2016 ◽

Vol 11 (8) ◽

pp. e0158354 ◽

Author(s):

Gerit Theil ◽

Kersten Fischer ◽

Ekkehard Weber ◽

Rita Medek ◽

Raschid Hoda ◽

...

Keyword(s):

Prostate Cancer ◽

Tumor Cells ◽

Clinical Outcomes ◽

Circulating Tumor Cells ◽

Proof Of Concept ◽

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Enrichment of circulating tumor cells from a large blood volume using leukapheresis and elutriation: Proof of concept

Cytometry Part B Clinical Cytometry ◽

10.1002/cyto.b.20560 ◽

2010 ◽

Vol 80B (2) ◽

pp. 100-111 ◽

Author(s):

Robert L. Eifler ◽

Judith Lind ◽

Dieter Falkenhagen ◽

Viktoria Weber ◽

Michael B. Fischer ◽

...

Keyword(s):

Tumor Cells ◽

Circulating Tumor Cells ◽

Blood Volume ◽

Proof Of Concept

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Circulating Tumor Cells Predict Outcome in Metastatic Breast Ca

Internal Medicine News ◽

10.1016/s1097-8690(05)70257-2 ◽

2005 ◽

Vol 38 (7) ◽

pp. 12

Keyword(s):

Tumor Cells ◽

Circulating Tumor Cells ◽

Metastatic Breast

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Impact of Disseminated Tumor Cells in Bone Marrow and Circulating Tumor Cells in the Blood of Breast Cancer Patients

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0028-1121889 ◽

2008 ◽

Vol 68 (12) ◽

Author(s):

V Müller ◽

T Fehm ◽

W Janni ◽

K Pantel

Keyword(s):

Breast Cancer ◽

Bone Marrow ◽

Cancer Patients ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Disseminated Tumor Cells ◽

Breast Cancer Patients

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Characterization and potential clinical implications of different subtypes of circulating tumor cells in patients with hepatocellular carcinoma

Zeitschrift für Gastroenterologie ◽

10.1055/s-0032-1332085 ◽

2013 ◽

Vol 51 (01) ◽

Author(s):

I Nel ◽

HA Baba ◽

J Ertle ◽

F Weber ◽

B Sitek ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Clinical Implications

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CTCtrap – Circulating Tumor Cells TheRapeutic APheresis: a novel biotechnology enabling personalized therapy for all cancer patients

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0034-1388519 ◽

2014 ◽

Vol 74 (S 01) ◽

Author(s):

H Neubauer ◽

N Kasprowicz ◽

B Rack ◽

C Vizler ◽

M Scholz ◽

...

Keyword(s):

Cancer Patients ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Personalized Therapy

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The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a study in 107 patients

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0034-1388600 ◽

2014 ◽

Vol 74 (S 01) ◽

Author(s):

M Wallwiener ◽

AD Hartkopf ◽

S Riethdorf ◽

J Nees ◽

FA Taran ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Tumor Cells ◽

Circulating Tumor Cells ◽

Metastatic Breast ◽

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