scholarly journals The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes - A Proof-of-Concept Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0158354 ◽  
Author(s):  
Gerit Theil ◽  
Kersten Fischer ◽  
Ekkehard Weber ◽  
Rita Medek ◽  
Raschid Hoda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Cells ◽  
Clinical Outcomes ◽  
Circulating Tumor Cells ◽  
Proof Of Concept ◽  
Concept Study

Besser als Genexpressionstests?

2018 ◽  
Vol 09 (02) ◽  
pp. 65-66
Author(s):  
Alexander Kretzschmar
Keyword(s):  
New York ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Proof Of Concept ◽  
Zirkulierende Tumorzellen

Zirkulierende Tumorzellen (Circulating Tumor Cells; CTC) sind Prädiktoren von Spät-rezidiven bei Frauen mit einem Hormonrezeptor-positiven (HR-positiv), HER2-negativen frühen Mammakarzinom. Dies ergab eine Proof-of-Concept-Studie, die von Dr. Joseph Sparano, New York, auf dem SABCS 2017 vorgestellt wurde. Spätrezidive machen etwa die Hälfte aller Östrogenrezeptor-positiven Rezidive aus. Genexpressionstests können zwar das Risiko eines Rezidivs insgesamt quantifizieren. Sparanos Arbeitsgruppe glaubt aber, dass CTC bessere Biomarker für Spätrezidive sind.

scholarly journals Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
M. Craig Miller ◽  
Gerald V. Doyle ◽  
Leon W. M. M. Terstappen
Keyword(s):  
Prostate Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Treatment Options ◽  
Venous Blood ◽  
Metastatic Breast ◽  
Cellsearch System ◽  
Multicenter Studies ◽  
Real Time Analysis ◽  
Number Of Treatment

The increasing number of treatment options for patients with metastatic carcinomas has created a concomitant need for new methods to monitor their use. Ideally, these modalities would be noninvasive, be independent of treatment, and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells (CTCs) shed into the blood during metastasis may satisfy this need. We developed the CellSearch System to enumerate CTC from 7.5 mL of venous blood. In this review we compare the outcomes from three prospective multicenter studies investigating the use of CTC to monitor patients undergoing treatment for metastatic breast (MBC), colorectal (MCRC), or prostate cancer (MPC) and review the CTC definition used in these studies. Evaluation of CTC at anytime during the course of disease allows assessment of patient prognosis and is predictive of overall survival.

scholarly journals Lack of Impact of Robotic Assisted Laparoscopic Radical Prostatectomy on Intraoperative Levels of Prostate Cancer Circulating Tumor Cells

2016 ◽  
Vol 195 (4 Part 1) ◽  
pp. 1136-1142 ◽  
Author(s):  
Eric C. Kauffman ◽  
Min-Jung Lee ◽  
Sylvia V. Alarcon ◽  
Sunmin Lee ◽  
Anthony N. Hoang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Laparoscopic Radical Prostatectomy ◽  
Robotic Assisted
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