Hemostatic Parameters in Newborn - II. Sequential Study During the First Four Weeks of Life

SummaryA sequential study of kaolin cephalin clotting time (KCCT), prothrombin time (PT), thrombin time (TT), plasma fibrinogen and serum FDP was conducted during the first four weeks of life on term and preterm babies. A “physiological dip” of PT and TT was noted inappropriate for gestational age (AGA) babies both term and preterm; in case of KCCT, the dip was significant in term AGA babies only. At the end of four weeks, PT and TT had moderately improved in term babies but showed little improvement in preterm ones; KCCT reached almost an adult value in all babies except in preterm AGA and term LGA (large for gestational age) ones. Plasma fibrinogen showed no “physiological dip” and reached adult level in two to four weeks. Serum FDP levels were appreciably raised in preterm AGA babies only at birth and there too normalised by 72 h.

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Hemostatic Parameters in Newborn - I. Effect of Gestation and Rate of Intrauterine Growth

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661444 ◽

1986 ◽

Vol 55 (01) ◽

pp. 047-050 ◽

Cited By ~ 8

Author(s):

B Dube ◽

R K Dube ◽

V Bhargava ◽

J K Kolindewala ◽

V L N Kota ◽

...

Keyword(s):

Gestational Age ◽

The Other ◽

Plasma Fibrinogen ◽

Large For Gestational Age ◽

Term Neonates ◽

Intrauterine Growth ◽

Appropriate For Gestational Age ◽

History Of ◽

Preterm Babies ◽

Preterm Newborns

SummaryThe present study comprises of 208 term, 159 preterm and 18 post-term neonates born to mothers with no history of drug intake or any disease likely to effect coagulation of the newborn. PT, TT and KCCT were relatively prolonged and plasma fibrinogen reduced to varying degree in newborns (as compared to adults). There was further prolongation of TT and reduction in plasma fibrinogen levels amongst preterm newborns as compared to term babies; TT was more prolonged amongst post-term babies also. PT was significantly more prolonged till 30 weeks of gestation, after which a near plateau was formed. KCCT showed significant improvement after 33 weeks and a further trend to normalisation after 38 weeks of gestation. Serum FDP values showed too much of variation for any meaningful statistical analysis but generally FDPs were higher in preterm babies. Intrauterine growth rate had no significant effect on these parameters amongst preterms -similar values for SGA (small for gestational age), AGA (appropriate for gestational age) and LGA (large for gestational age). On the other hand, amongst term babies SGA neonates had significantly prolonged PT and low plasma fibrinogen as compared to AGA; LGA babies also showed more prolongation of TT as compared to AGA.

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Blood Coagulation and Fibrinolysis in Haemorrhagic Stroke

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646658 ◽

1978 ◽

Vol 39 (01) ◽

pp. 084-088 ◽

Cited By ~ 1

Author(s):

Rama Kanta Dube ◽

P V B Rao ◽

P K Saha ◽

B C Katiyar ◽

B Dube

Keyword(s):

Platelet Count ◽

Prothrombin Time ◽

Fibrinolytic Activity ◽

Haemorrhagic Stroke ◽

Factor V ◽

Thrombin Time ◽

Clotting Time ◽

Plasma Recalcification Time ◽

Recalcification Time ◽

Coagulation And Fibrinolysis

SummaryStudies of 11 patients with haemorrhagic stroke revealed no significant change in kaolin cephalin clotting time, prothrombin time, thrombin time, PF 3 availability, platelet count and factor V and VIII during the first week. Plasma fibrinogen was significantly increased while factors VII+X were decreased (borderline significance). Prolongation of plasma recalcification time and decrease in heparin tolerance reached borderline significance. There was moderate, but significant, increase in serum antithrombin activity and plasma (euglobulin fraction) fibrinolytic activity.

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Effect of heparin on chronically induced intravascular coagulation in dogs

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1975.229.2.449 ◽

1975 ◽

Vol 229 (2) ◽

pp. 449-454 ◽

Cited By ~ 5

Author(s):

Owen CA ◽

EJ Bowie

Keyword(s):

Factor Viii ◽

Prothrombin Time ◽

Antithrombin Iii ◽

Plasma Fibrinogen ◽

Factor V ◽

Thrombin Time ◽

Turnover Rates ◽

Clotting Factors ◽

Intravascular Coagulation ◽

Absolute Concentrations

When intermediate-strength thromboplastin was continuously infused into dogs for 10 days or more, platelet counts decreased sharply and factor VIII concentrations decreased by more than 50%. There was little change in plasma fibrinogen, prothrombin, factor V, antithrombin III, plasminogen, prothrombin time, and thrombin time values. When heparin was infused (25-50 U/kg per h) along with the same thromboplastin, there was no change in onset or degree of thrombocytopenia. However, the decrease in factor VIII was abolished and there were significant increases in fibrinogen, prothrombin, and factor V. The absolute concentrations of the various clotting factors seemed to give no indication of their turnover rates. Unexplained is the remarkable heparin tolerance that developed in these dogs.

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