Abstract
Background: Exercise intervention and dietary supplementation are considered as approaches to manage obesity, as well as, metabolic syndrome (MetS). The aim of the present study was to evaluate the effect of sodium alginate supplementation with high intensity interval training (HIIT) or moderate-intensity continuous training (MICT) on serum levels of glucagon and glucagon-like peptide-1 (GLP-1) in women with MetS.Methods: This randomized controlled clinical trial was performed on 46 women with MetS. Participants were randomly divided to six groups including: 1) HIIT+ sodium alginate (HS, n=8); 2) HIIT+ placebo (HP, n=8); 3) MICT+ sodium alginate (MS, n=8); 4) MICT+ placebo (MP, n=8); 5) sodium alginate (S, n=7); and 6) control group (P, n=7). Sodium alginate were prescribed 1.5 gram alone or along with HIIT or MICT sessions (3 times per week). Anthropometric indices, glycemic profile, serum level of glucagon and GLP-1 were measured before and after 8 weeks intervention. Results: In HS, HP, MS, and MP groups the mean of weight (p=0.000), body mass index (p=0.001), fasting blood sugar (p=0.003), insulin (p=0.000), insulin resistance (p=0.043), and glucagon (p=0.011) decreased significantly, however GLP_1 (p=0/01) level increased significantly after intervention.Conclusion: Since HIIT and MICT with or without sodium alginate supplementation leads to improvement in anthropometric indices, glycemic profile, serum GLP-1 and glucagon levels, it can be stated that the training method of the present study is suitable for improving and reducing complications associated with MetS in women.Trial registration: IRCT20191116045457N1. Registered 27 jan 2020, https://en.irct.ir/trial/43776