A Pasteurised Concentrate of Human Plasma Factor XIII for Therapeutic Use
1986 ◽
Vol 55
(03)
◽
pp. 402-405
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Keyword(s):
SummaryA therapeutic concentrate of factor XIII containing both A and B sub-units has been prepared from 300 kg pools of human plasma. The process starts from a cold-ethanol fraction from cryoprecipitate supernatant and therefore does not interfere with the recovery of other clinically valuable plasma proteins. Factor XIII is purified approximately 600-fold from plasma by precipitation with sodium citrate and by the removal of fibrinogen by brief heating. The product has been pasteurised in sorbitol solution to inactivate blood-borne viruses, ultrafiltered to remove sorbitol, adsorbed with bentonite and freeze-dried in a formulation meeting requirements for intravenous injection.
Keyword(s):
1976 ◽
Vol 5
(6)
◽
pp. 329-340
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1977 ◽
Vol 38
(02)
◽
pp. 0438-0446
◽
2007 ◽
Vol 52
(12)
◽
pp. 3488-3492
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Keyword(s):