Further Studies on the Modulation of Blood Coagulation by Human Serum Amyloid P Component and Its Acute Phase Homologue C-Reactive Protein

1986 ◽  
Vol 55 (03) ◽  
pp. 406-409 ◽  
Author(s):  
B A Fiedel ◽  
Cecilia S L Ku
Keyword(s):  
Blood Coagulation ◽  
Acute Phase ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P ◽  
Free Plasma

SummarySerum amyloid P component (SAP), and its acute phase homologue C-reactive protein (CRP), prolonged activated partial thromboplastin times (APTT) in cell free plasma when assayed at physiological concentrations in the presence of heparin. SAP also inhibited clot formation initiated through the extrinsic and terminal phases of coagulation in heparinized cell free plasma, an activity not shared with CRP. When CRP and SAP were similarly evaluated in whole blood using the thromboelastograph (TEG), CRP delayed the onset of coagulation and the initial rate of fibrin formation/polymerization; final clot patency was unaltered. SAP suppressed the anticoagulant activity of heparin in the TEG assay, unlike results obtained in heparinized cell free plasma, by facilitating a more rapid onset of coagulation, increasing the rate of fibrin formation/polymerization, and correcting clot patency. The data provided offer further evidence that these homologues can intercede in blood coagulation.

scholarly journals Complement-Dependent Acute-Phase Expression of C-Reactive Protein and Serum Amyloid P-Component

2000 ◽  
Vol 165 (2) ◽  
pp. 1030-1035 ◽  
Author(s):  
Alexander J. Szalai ◽  
Frederik W. van Ginkel ◽  
Yue Wang ◽  
Jerry R. McGhee ◽  
John E. Volanakis
Keyword(s):  
Acute Phase ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P

scholarly journals Vitamin D Correction Down-Regulates Serum Amyloid P Component Levels in Vitamin D Deficient Arab Adults: A Single-Arm Trial

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2880
Author(s):  
Osama Amer ◽  
Malak Khattak ◽  
Abdullah Alnaami ◽  
Naji Aljohani ◽  
Nasser Al-Daghri
Keyword(s):  
Vitamin D ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Post Intervention ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Study Participants ◽  
Amyloid P

Vitamin D (VD) has been observed to have anti-inflammatory properties. However, the effects of VD supplementation on the serum amyloid P component (SAP) has not been established. This study aimed to investigate the effect of VD supplementation on serum SAP levels in Arab adults. A total of 155 VD-deficient adult Saudis (56 males and 99 females) were recruited in this non-randomized, 6-month, single-arm trial. The intervention was as follows; cholecalciferol 50,000 international units (IU) every week for the first 2 months, followed by 50,000 twice a month for the next two months, and for the last two months, 1000 IU daily. Serum 25(OH)D, SAP, C-reactive protein (CRP), lipid profile, and glucose were assessed at baseline and post-intervention. At post-intervention, VD levels were significantly increased, while SAP levels significantly decreased in all study participants. Remarkably, this reduction in SAP was more significant in males than females after stratification. SAP was inversely correlated with VD overall (r = −0.17, p < 0.05), and only in males (r = −0.27, p < 0.05) after stratification according to sex after 6 months of VD supplementation. Such a relationship was not observed at baseline. VD supplementation can favorably modulate serum SAP concentrations in Arab adults, particularly in males.

Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component

Amyloid ◽  
2017 ◽  
Vol 24 (sup1) ◽  
pp. 28-29 ◽  
Author(s):  
Daisaku Ozawa ◽  
Ryo Nomura ◽  
P. Patrizia Mangione ◽  
Kazuhiro Hasegawa ◽  
Tadakazu Okoshi ◽  
...  
Keyword(s):  
Serum Amyloid ◽  
C Reactive Protein ◽  
Amyloid P Component ◽  
Reactive Protein ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Amyloid P
Sign in / Sign up

Export Citation Format

Share Document