scholarly journals Functionalised Nitrogen Heterocycles and the Search for New Antibacterials and Bioactives

Synthesis ◽  
2020 ◽  
Vol 52 (11) ◽  
pp. 1602-1616 ◽  
Author(s):  
Mark G. Moloney ◽  
Muhammad Kamran Khan ◽  
Dandan Wang
Keyword(s):  
Biological Activity ◽  
Drug Discovery ◽  
Natural Product ◽  
Nitrogen Heterocycles ◽  
Natural Product Synthesis ◽  
Antibacterial Drug ◽  
Metal Chelation ◽  
Synthetic Routes

The importance of, and synthetic routes to, pyrrolidines and piperidines, along with their relevance to natural product synthesis and antibacterial drug discovery, are surveyed in the context of an extended programme of investigation from our own laboratories.1 Introduction2 Pyroglutamates2.1 Synthesised by Modification of an Existing Ring2.2 Synthesised by Construction of a New Ring3 Tetramates4 Metal Chelation5 Biological Activity6 Conclusion

scholarly journals A landmark in drug discovery based on complex natural product synthesis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Satoshi Kawano ◽  
Ken Ito ◽  
Kenzo Yahata ◽  
Kazunobu Kira ◽  
Takanori Abe ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Natural Product ◽  
Natural Product Synthesis

scholarly journals Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

2011 ◽  
Vol 7 ◽  
pp. 1475-1485 ◽  
Author(s):  
Charles Dylan Turner ◽  
Marco A Ciufolini
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Fredericamycin A

This is a review of our efforts toward the synthesis of a group of natural products that display noteworthy biological activity: Fredericamycin A, nothapodytine B, and topopyrones B and D. In each case, directed aromatic functionalization methodology greatly facilitated the assembly of the key molecular subunits.

scholarly journals Bridging the gap between natural product synthesis and drug discovery

2020 ◽  
Vol 37 (11) ◽  
pp. 1436-1453 ◽  
Author(s):  
Nathanyal J. Truax ◽  
Daniel Romo
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Natural Product ◽  
Chemical Space ◽  
Natural Product Synthesis ◽  
Chemical Information

Various synthetic strategies have been developed to explore natural products as an enduring source of chemical information useful for probing biological relevant chemical space and impacting drug discovery.

Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis

2020 ◽  
Vol 18 (15) ◽  
pp. 2793-2812 ◽  
Author(s):  
Rabdan M. Tikhov ◽  
Nikolai Yu. Kuznetsov
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Drug Development ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Modern Drug

The review surveys the existing routes to piperidine-2,4-dione-type heterocycles including derivatives with the most vital types of biological activity. This heterocyclic platform is ideal for the construction of modern drugs and natural products.

Synthesis of α-exo-Methylene-γ-butyrolactone: Recent Developments and Applications in Natural Product Synthesis

Synthesis ◽  
2021 ◽  
Author(s):  
Weilong Liu ◽  
Nicolas Winssinger
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Total Synthesis ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Vast Array ◽  
The Past ◽  
New Approaches ◽  
Recent Developments

The α-exo-methylene-γ-butyrolactone moiety is present in a vast array of structurally diverse natural products and is often central to their biological activity. In this review, we summarize new approaches to α-exo-methylene-γ-butyrolactones developed over the past decade as well as their applications in total synthesis.

Palladium catalysed meta-C–H functionalization reactions

2016 ◽  
Vol 14 (24) ◽  
pp. 5440-5453 ◽  
Author(s):  
Aniruddha Dey ◽  
Soumitra Agasti ◽  
Debabrata Maiti
Keyword(s):  
Drug Discovery ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Material Sciences ◽  
Directing Group ◽  
Site Selective

The directing group assisted site selective C–H functionalization approach is having a continuous impact in the field of natural product synthesis, drug discovery and material sciences.

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