Interobserver Variability in the Differential Diagnosis of Benign Bone Tumors and Tumor-like Lesions

AbstractBackground: CERAMENT™|BONE VOID FILLER is an injectable and moldable ceramic bone substitute material intended for bone voids. The material consists of hydroxyapatite and calcium sulfate hemihydrate. The aim of this study is to present the first long-term results following open curettage of benign bone tumors and tumor-like lesions and void filling with this novel injectable and synthetic bone graft. Methods: Thirty three patients were enrolled into the study between June 2013 and October 2014 .Totally, we treated 24 women and 9 men with a median age of 47 years (range: 22-74). All patients suffered from primary musculoskeletal system disorders (enchondroma 63,6%, giant cell tumor 18%, aneurysmal bone cyst 9%, fibrous dysplasia 9%, Gaucher disease 3%). We performed curettage of pathological lesions, then the bone substitute was administered by means of needle to the void. Results: The average follow-up was 13 months (range: 2-13 months, median 10 months). No metastasis or recurrence had been detected. We received significant clinical improvement relating to VAS, MSTS, and oncological results. Conclusions: The results of our study report that CERAMENT can be successfully used as a bone substitute in patients with various bone diseases, as well as benign bone tumors. CERAMENT can provide an effective and long-term solution for reconstructive procedures following curettage of bone tumors and tumor like lesions.

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Hydatid Disease of the Femur with an Extraosseous Extent due to a Former Biopsy Complicated by a Pathological Fracture

Case Reports in Orthopedics ◽

10.1155/2012/169545 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

M. Ciftdemir ◽

A. Sezer ◽

F. O. Puyan ◽

C. Copuroglu ◽

M. Ozcan

Keyword(s):

Differential Diagnosis ◽

Hydatid Disease ◽

Needle Biopsy ◽

Bone Tumors ◽

Pathological Fracture ◽

Clinical Findings ◽

Bone Biopsies ◽

Cortical Erosion ◽

Tumor Like Lesions ◽

Rare Diagnosis

Hydatid disease of the bone represents about 1–2.5% of all human hydatid disease. Spine is the most affected part of the skeleton with 50% incidence of all bone hydatidosis. Extraspinal bone hydatidosis is much rare. Diagnosis is difficult in the bone hydatid disease. Bone tumors, tumor-like lesions, and specific and nonspecific infections should be considered in the differential diagnosis. Radiological, laboratory, and clinical findings combined with strong element of suspicion are the key for diagnosis. Bone biopsies should be avoided because of the danger of anaphylaxis, sensitization, and spread. This paper describes the management of a patient with primary hydatidosis of the femur, which had been complicated by an extraosseous involvement, cortical erosion, and a pathological fracture due to a former needle biopsy.

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KPNA2 expression is a potential marker for differential diagnosis between osteosarcomas and other malignant bone tumor mimics

Diagnostic Pathology ◽

10.1186/s13000-020-01051-6 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Lucen Jiang ◽

Jianghuan Liu ◽

Qingzhu Wei ◽

Yiyang Wang

Keyword(s):

Differential Diagnosis ◽

Bone Tumor ◽

Bone Tumors ◽

Bone Sarcoma ◽

Malignant Bone Tumor ◽

Diagnostic Biomarker ◽

Malignant Bone Tumors ◽

Benign Bone Tumors ◽

Potential Marker ◽

Osteoblastic Osteosarcoma

Abstract Background Karyopherin α2 (KPNA2), a member of the karyopherin α family, has been studied in several cancers but has not yet been substantially investigated in malignant bone tumors. The purpose of the current study was to evaluate the KPNA2 expression level and its utility as a novel diagnostic biomarker in osteosarcomas and malignant bone tumor mimics, such as chondrosarcomas and Ewing sarcomas (ESs). Method We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin-embedded surgical specimens from 223 patients with malignant and benign bone tumors, including 81 osteosarcomas, 42 chondrosarcomas, 15 ESs, 28 osteoid osteomas, 20 osteochondromas and 37 chondroblastomas. Immunoreactivity was scored semiquantitatively based on staining extent and intensity. Results Sixty-seven of 81 (82.7%) osteosarcoma, zero of 42 (0%) chondrosarcoma and one of 15 (6.7%) ES samples showed immunoreactivity for KPNA2. Negative KPNA2 expression was observed in all benign bone tumors. The expression of KPNA2 in osteosarcoma samples was much higher than that in chondrosarcoma and ES samples (P < 0.001). The sensitivity and specificity of KPNA2 immunoexpression for detecting osteosarcoma were 82.7 and 100%, respectively. Several subtypes of osteosarcoma were analyzed, and immunostaining of KPNA2 was frequent in osteoblastic samples (90.9%), with 39 samples (70.9%) showing strong-intensity staining. KPNA2 positivity was observed in ten of 13 (76.9%) chondroblastic, two of 6 (33.3%) fibroblastic, three of 4 (75%) telangiectatic and two of 3 (66.7%) giant cell-rich osteosarcoma samples. The strongest intensity staining was observed in osteoblastic osteosarcoma. Conclusion KPNA2 is frequently expressed in osteosarcomas, particularly in osteoblastic and chondroblastic tumors, but is rarely positive in chondrosarcomas and ESs. This feature may aid in distinguishing between osteosarcoma and other bone sarcoma mimics. This report supports KPNA2 as a novel marker for the diagnosis of osteosarcoma.

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Benign Bone Tumors and Tumor-Like Lesions

MR Imaging of the Body ◽

10.1055/b-0034-77932 ◽

2009 ◽

Keyword(s):

Bone Tumors ◽

Benign Bone Tumors ◽

Tumor Like Lesions

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Telomerase Activity in Benign Bone Tumors and Tumor-like Lesions

Pathology - Research and Practice ◽

10.1016/s0344-0338(99)80117-4 ◽

1999 ◽

Vol 195 (11) ◽

pp. 753-757 ◽

Cited By ~ 6

Author(s):

Akira Kido ◽

Repine Schneider-Stock ◽

Kathrin Hauptmann ◽

Albert Roessner

Keyword(s):

Bone Tumors ◽

Telomerase Activity ◽

Benign Bone Tumors ◽

Tumor Like Lesions

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Benign bone tumors and tumor-like lesions: value of cross-sectional imaging

European Radiology ◽

10.1007/s00330-003-1902-z ◽

2003 ◽

Vol 13 (8) ◽

pp. 1820-1835 ◽

Cited By ~ 73

Author(s):

Klaus Woertler

Keyword(s):

Bone Tumors ◽

Cross Sectional ◽

Benign Bone Tumors ◽

Cross Sectional Imaging ◽

Sectional Imaging ◽

Tumor Like Lesions

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Talar Osteochondroma Fracture Presenting as Posterior Ankle Impingement

Journal of the American Podiatric Medical Association ◽

10.7547/15-001 ◽

2016 ◽

Vol 106 (3) ◽

pp. 225-228 ◽

Cited By ~ 2

Author(s):

Ersin Ercin ◽

Mustafa Gokhan Bilgili ◽

Mehmet Gamsizkan ◽

Serdar Avsar

Keyword(s):

Differential Diagnosis ◽

Bone Tumors ◽

Surgical Intervention ◽

Rare Condition ◽

Histologic Examination ◽

Posterior Aspect ◽

Benign Bone Tumors ◽

Ankle Impingement ◽

Posterior Ankle Impingement

Osteochondromas are the most common benign bone tumors. They are usually asymptomatic and found incidentally. When symptomatic, the symptoms are usually due to its location and size. Fracture of an osteochondroma presenting as posterior ankle impingement is a rare condition. We describe a 22-year-old man with solitary exostosis who presented with a posterior ankle mass and posterior ankle impingement with 2 years of follow-up. Surgical intervention was the treatment of choice in this patient, and histologic examination revealed a benign osteochondroma. Osteochondromas found in the posterior aspect of the talus can be complicated by fracture due to persistent motion of the ankle. Talar osteochondroma should be included in the differential diagnosis of posterior ankle impingement causes. Posterior talar osteochondromas, especially when a stalk is present, should be treated surgically before it is more complicated by a fracture and posterior ankle impingement.

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Benign Bone Tumors about the Hip

The Journal of Hip Surgery ◽

10.1055/s-0039-1678741 ◽

2019 ◽

Vol 03 (01) ◽

pp. 008-013

Author(s):

Jay Patel ◽

Arianna Gianakos ◽

Justin Miller ◽

Tyler Hoskins ◽

James Wittig

Keyword(s):

Differential Diagnosis ◽

Bone Tumors ◽

Hip Pain ◽

Benign Bone Tumors

AbstractHip pain can often be a challenging patient complaint with a complicated differential diagnosis, in part because there are numerous etiologies of both primary and referred hip pain. It is critical that clinicians be able to properly diagnose and treat these etiologies. Here, the authors present the incidence, characteristics, and treatment of various benign bone tumors around the hip to help clinicians accurately identify these conditions.

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