Quantitative Carbon Isotope Labeling of Carboxylic Acids

Synfacts ◽  
2021 ◽  
Vol 18 (01) ◽  
pp. 0042
Keyword(s):  
Carbon Isotope ◽  
Carboxylic Acids ◽  
Isotope Labeling

scholarly journals Cover Feature: A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides (Chem. Eur. J. 24/2021)

2021 ◽  
Vol 27 (24) ◽  
pp. 6998-6998
Author(s):  
Simon S. Pedersen ◽  
Aske S. Donslund ◽  
Jesper H. Mikkelsen ◽  
Oskar S. Bakholm ◽  
Florian Papp ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Isotope Labeling ◽  
J 24

A Nickel(II)‐Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides

2021 ◽  
Author(s):  
Simon S. Pedersen ◽  
Aske S. Donslund ◽  
Jesper H. Mikkelsen ◽  
Oskar S. Bakholm ◽  
Florian Papp ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Isotope Labeling

scholarly journals Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

2021 ◽  
Vol 143 (5) ◽  
pp. 2200-2206
Author(s):  
Duanyang Kong ◽  
Maxime Munch ◽  
Qiqige Qiqige ◽  
Christopher J. C. Cooze ◽  
Benjamin H. Rotstein ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Carboxylic Acids ◽  
Isotope Exchange ◽  
Photoredox Catalysis

Charge distribution in turbostratic few-layer graphene studied by carbon isotope labeling

Carbon ◽  
2021 ◽  
Author(s):  
Pingping Zhuang ◽  
Jing Liu ◽  
Junjie Huang ◽  
Chao Dou ◽  
Weiwei Cai ◽  
...  
Keyword(s):  
Carbon Isotope ◽  
Charge Distribution ◽  
Isotope Labeling ◽  
Layer Graphene ◽  
Few Layer Graphene

scholarly journals Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis

2020 ◽  
Author(s):  
Duanyang Kong ◽  
Maxime Munch ◽  
Qiqige Qiqige ◽  
Christopher Cooze ◽  
Benjamin Rotstein ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carbon Isotope ◽  
Carboxylic Acids ◽  
Isotope Exchange ◽  
Room Temperature ◽  
Reaction Times ◽  
Thermally Induced ◽  
Drug Molecules ◽  
Metal Catalyzed ◽  
Isotopic Incorporation

Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3 )-acids with labelled CO2. Substrates that are not compatible with transition metal catalyzed degradation-reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabelling of drug molecules and precursors with [11C]CO2 is demonstrated.

scholarly journals Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation

2020 ◽  
Vol 56 (78) ◽  
pp. 11677-11680
Author(s):  
Antonio Del Vecchio ◽  
Alex Talbot ◽  
Fabien Caillé ◽  
Arnaud Chevalier ◽  
Antoine Sallustrau ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Carbon Isotopes ◽  
Late Stage ◽  
Building Block ◽  
Isotope Labeling

A procedure which allows labelling cyclic carbamates with all carbon isotopes has been developed. This protocol valorizes carbon dioxide, the universal building block for radiolabeling. A series of pharmaceuticals were obtained and a disconnection/reconnection strategy was implemented.

Investigation on the Stoichiometry of Carbon Dioxide in Isotope-Exchange Reactions with Phenylacetic Acids

Synlett ◽  
2021 ◽  
Author(s):  
Davide Audisio ◽  
Alex Talbot ◽  
Antoine Sallustrau ◽  
Amélie Goudet ◽  
Frédéric Taran
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Isotope Exchange ◽  
Isotope Labeling ◽  
Exchange Reactions ◽  
Major Interest ◽  
Carbon Dioxide Co2 ◽  
Dilution Effects ◽  
Product Outcome ◽  
Insight Into

AbstractThe functionalization of carbon dioxide (CO2) as a C1 building block has attracted enormous attention. Carboxylation reactions, in particular, are of major interest for applications in isotope labeling. Due to the inexpensive nature of CO2, information about its stoichiometric use is generally unavailable in the literature. Because of the rarity and limited availability of CO2 isotopomers, this parameter is of concern for applications in carbon-isotope labeling. We investigated the effects of the stoichiometry of labeled CO2 on carbon isotope exchange of phenyl­acetic acids. Both thermal and photocatalytic procedures were studied, providing insight into product outcome and isotope incorporation. Preliminary results on isotope-dilution effects of carbonate bases in photocatalytic carboxylation reactions have also been obtained.

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