Investigation on the Stoichiometry of Carbon Dioxide in Isotope-Exchange Reactions with Phenylacetic Acids

Synlett ◽  
2021 ◽  
Author(s):  
Davide Audisio ◽  
Alex Talbot ◽  
Antoine Sallustrau ◽  
Amélie Goudet ◽  
Frédéric Taran
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Isotope Exchange ◽  
Isotope Labeling ◽  
Exchange Reactions ◽  
Major Interest ◽  
Carbon Dioxide Co2 ◽  
Dilution Effects ◽  
Product Outcome ◽  
Insight Into

AbstractThe functionalization of carbon dioxide (CO2) as a C1 building block has attracted enormous attention. Carboxylation reactions, in particular, are of major interest for applications in isotope labeling. Due to the inexpensive nature of CO2, information about its stoichiometric use is generally unavailable in the literature. Because of the rarity and limited availability of CO2 isotopomers, this parameter is of concern for applications in carbon-isotope labeling. We investigated the effects of the stoichiometry of labeled CO2 on carbon isotope exchange of phenyl­acetic acids. Both thermal and photocatalytic procedures were studied, providing insight into product outcome and isotope incorporation. Preliminary results on isotope-dilution effects of carbonate bases in photocatalytic carboxylation reactions have also been obtained.

scholarly journals Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation

2020 ◽  
Vol 56 (78) ◽  
pp. 11677-11680
Author(s):  
Antonio Del Vecchio ◽  
Alex Talbot ◽  
Fabien Caillé ◽  
Arnaud Chevalier ◽  
Antoine Sallustrau ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Carbon Isotopes ◽  
Late Stage ◽  
Building Block ◽  
Isotope Labeling

A procedure which allows labelling cyclic carbamates with all carbon isotopes has been developed. This protocol valorizes carbon dioxide, the universal building block for radiolabeling. A series of pharmaceuticals were obtained and a disconnection/reconnection strategy was implemented.

scholarly journals Application of the Data on δ13C and δ18O of Carbonates for the Study of Unconventional Reservoirs on the Example of the Bazhenov Source Rocks, Western Siberia, Russia

Geosciences ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 264
Author(s):  
Anna Yurchenko ◽  
Andrey Voropaev ◽  
Elena Kozlova ◽  
Nikita Morozov ◽  
Mikhail Spasennykh
Keyword(s):  
Carbon Dioxide ◽  
Stable Isotope ◽  
Oxygen Isotope ◽  
Isotope Exchange ◽  
Isotope Composition ◽  
Source Rocks ◽  
Distribution Area ◽  
Exchange Reactions ◽  
Bazhenov Formation ◽  
Carbon And Oxygen Isotope

This paper addresses potential application of data on stable carbon and oxygen isotope composition of carbonates for study of organic rich source rocks on the example of the Late Jurassic–Early Cretaceous Bazhenov Formation (West Siberian petroleum basin, Russia). Geochemical studies were conducted for sections located in central (most productive) and peripheral (northern and southern) regions of the Bazhenov Formation distribution area, containing deposits formed under different conditions. We identified key factors impacting stable isotope composition of carbonate minerals and established relation of their isotope composition to the formation conditions. Using a thermodynamic model of carbon and oxygen isotope exchange in the carbonate–water–carbon dioxide system, it is shown that variations in the isotope composition of secondary carbonates are affected by isotopic composition of primary carbonates in sediments and by the isotope exchange reactions with water and carbon dioxide, generated during the source rocks transformation. Our results demonstrate that stable isotope data for carbonates in the Bazhenov Formation together with standard geochemical methods can be efficiently applied to determine sedimentation conditions and secondary alteration processes of oil source rocks.

scholarly journals Robust and General Procedure for Carbon Isotope Labeling of Linear Urea Derivatives with Carbon Dioxide

2021 ◽  
Author(s):  
Victor Babin ◽  
Antoine Sallustrau ◽  
Olivier Loreau ◽  
Fabien Caillé ◽  
Amélie Goudet ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Full Article ◽  
Carbon Isotope ◽  
Carbon Isotopes ◽  
Isotope Labeling ◽  
General Procedure ◽  
Urea Derivatives ◽  
Living Organisms ◽  
Approved Drugs ◽  
Fda Approved Drugs

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. Despite recent advances in the field, the development of robust and general technologies remains a significant task. This full article reports on a general approach to label urea derivatives with all carbon isotopes, including <sup>14</sup>C and <sup>11</sup>C. Based on a Staudinger aza-Wittig sequence, it provides access to all aliphatic/aromatic urea combinations as well as to semicarbazides, sulfonylureas, hydroxyl ureas, and simple terminal ureas. A de-risking approach was developed to evaluate the robustness of the reaction. This technology is based on [<sup>14</sup>C]CO<sub>2</sub> screening that allowed to investigate the tolerance of the procedure with most representative heterocycles and functional groups found in FDA approved drugs.

A Highly Durable, Self-Photosensitized Mononuclear Ruthenium Catalyst for CO2 Reduction

Synlett ◽  
2021 ◽  
Author(s):  
Kenji Kamada ◽  
Hiroko Okuwa ◽  
Taku Wakabayashi ◽  
Keita Sekizawa ◽  
Shunsuke Sato ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Monoxide ◽  
Reaction Time ◽  
Formic Acid ◽  
Induction Period ◽  
Isotope Labeling ◽  
Co2 Reduction ◽  
Tetradentate Ligand ◽  
Ru Complex ◽  
Carbon Dioxide Co2

A novel mononuclear ruthenium (Ru) complex bearing a PNNP-type tetradentate ligand is introduced here as a self-photosensitized catalyst for the reduction of carbon dioxide (CO2). When the pre-activation of the Ru complex by reaction with a base was carried out, an induction period of catalyst almost disappeared and the catalyst turnover numbers (TONs) over a reaction time of 144 h reached 307 and 489 for carbon monoxide (CO) and for formic acid (HCO2H), respectively. The complex has a long lifespan as a dual photosensitizer and reduction catalyst, due to the sterically bulky and structurally robust (PNNP)Ru framework. Isotope labeling experiments under 13CO2 atmosphere indicate that CO and HCO2H were both produced from CO2.

General Procedure for Carbon Isotope Labeling of Linear Urea Derivatives with Carbon Dioxide

2021 ◽  
Author(s):  
Victor Babin ◽  
Antoine Sallustrau ◽  
Olivier Loreau ◽  
Fabien Caillé ◽  
Amélie Goudet ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Carbon Isotope ◽  
Organic Compounds ◽  
Isotope Labeling ◽  
General Procedure ◽  
Urea Derivatives ◽  
Living Organisms

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach...

scholarly journals Robust and General Procedure for Carbon Isotope Labeling of Linear Urea Derivatives with Carbon Dioxide

2021 ◽  
Author(s):  
Victor Babin ◽  
Antoine Sallustrau ◽  
Olivier Loreau ◽  
Fabien Caillé ◽  
Amélie Goudet ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Full Article ◽  
Carbon Isotope ◽  
Carbon Isotopes ◽  
Isotope Labeling ◽  
General Procedure ◽  
Urea Derivatives ◽  
Living Organisms ◽  
Approved Drugs ◽  
Fda Approved Drugs

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. Despite recent advances in the field, the development of robust and general technologies remains a significant task. This full article reports on a general approach to label urea derivatives with all carbon isotopes, including <sup>14</sup>C and <sup>11</sup>C. Based on a Staudinger aza-Wittig sequence, it provides access to all aliphatic/aromatic urea combinations as well as to semicarbazides, sulfonylureas, hydroxyl ureas, and simple terminal ureas. A de-risking approach was developed to evaluate the robustness of the reaction. This technology is based on [<sup>14</sup>C]CO<sub>2</sub> screening that allowed to investigate the tolerance of the procedure with most representative heterocycles and functional groups found in FDA approved drugs.

PERANCANGAN PROTEKSI KEBAKARAN OTOMATIS PADA KAPAL BERBASIS ARDUINO

2018 ◽  
Vol 1 (2) ◽  
pp. 1-8
Author(s):  
Dody Hidayat
Keyword(s):  
Carbon Dioxide ◽  
Fire Extinguisher ◽  
Carbon Dioxide Co2

Kebakaran dapat terjadi dimana saja salah satunya dapat terjadi di alat transportasi air yakni kapal. Kebakaran selalu menyebabkan hal-hal yang tidak diinginkan baik kerugian material maupun ancaman keselamatan jiwa manusia. Seiring dari kejadian tersebut musibah kecelakaan kapal yang disebabkan oleh bahaya kebakaran sangatlah mungkin terjadi. Salah satu yang dapat mencegah kejadian kebakaran pada kapal haruslah dapat mendeteksi dini kebakaran tersebut. Untuk mendeteksi dini terjadinya kebakaran dikapal maka dirancanglah sebuah alat proteksi kebakaran otomatisberbasis adruino. Dimana Arduino merupakan board yang memiliki sebuah mikrokontroller sebagai  otak kendali sistem. Sistem otomatisasi atau controller tidak akan terlepas dengan apa yang disebut  dengan ‘sensor’. Sensor adalah sebuah alat untuk mendeteksi atau mengukut sesuatu yang digunakan untuk mengubah variasi mekanis, magnetis, panas, sinar dan kimia menjadi tegangan dan arus listrik. sistem yang dirancang ini dilengkapi dengan beberapa sensor diantaranya adalah sensor apiUV-Tron R2868, sensor asap MQ-2 dan kemudian sensor suhuDS18B20. Mikrokontroller sebagai pengendali akan merespon input yang berupa sensor tersebut ketika data yang dibaca oleh sensor mendeteksikebakaran diantaranya mendeteksi adanya asap, kemudian api dan suhu. Sebagai output dari sistem berupa racun api (fire extinguisher)dimana kandungan yang ada pada racun api tersebut berupa Dry Chemical Powder dan Carbon Dioxide (CO2) yang fungsinya digunakan untuk memadamkan api serta dilengkapi buzzer sebagai alarm peringatan jika terjadi kebakaran. 

The Prenatal Development Effects of Carbon Dioxide (CO2) Exposure in Rats (Rattus Norvegicus)

2012 ◽  
Author(s):  
William R. Howard ◽  
Brian Wong ◽  
Michelle Okolica ◽  
Kimberly S. Bynum ◽  
R. A. James
Keyword(s):  
Carbon Dioxide ◽  
Rattus Norvegicus ◽  
Prenatal Development ◽  
Carbon Dioxide Co2
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