scholarly journals Intra-articular Injection of a Dextran Polymer Combined with Antibiotic Medications for Bacterial Infective Arthritis in Dogs: 14 Cases

VCOT Open ◽  
2021 ◽  
Vol 04 (02) ◽  
pp. e104-e110
Author(s):  
Matthew A. Lazarus ◽  
Stanley E. Kim ◽  
Daniel D. Lewis ◽  
Matthew D. Johnson
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Median Number ◽  
Joint Fluid ◽  
Cytological Evidence ◽  
Cell Counts ◽  
Infective Arthritis ◽  
Severe Grade ◽  
Number Of Injections ◽  
Fluid Cytology

Abstract Objectives The aim of this study was to describe the use of an intra-articular delivery of a dextran polymer (IADP) for bacterial infective arthritis in dogs. Materials and Methods Cases of bacterial infective arthritis treated with IADP were reviewed. Resolution of infection was based on joint fluid cytology. Lameness scores, total nucleated cell counts, and per cent neutrophils were monitored throughout treatment. Results There were 14 dogs included in the study. The stifle was the most commonly affected joint. The median number of injections per dog was 3 with a median of 2 weeks between injections. Amikacin was combined with the dextran polymer in 13 cases and imipenem was used in 1 case. Concurrent oral antimicrobials were used in 12/14 cases, and surgery for infection was performed in 10/14 cases. Cytological evidence of infection resolved in 11/14 cases. Median lameness scores throughout treatment decreased from severe (grade ¾) at initial presentation to mild (grade ¼) at the final recheck. Median total nucleated cell counts and per cent neutrophils decreased from 40,000 white blood cell/µL and 91% to 2,200 white blood cell/µL and 4% respectively. A transient worsening of lameness was the main side effect documented in 5/14 cases. Conclusion Intra-articular dextran polymer combined with antimicrobials was generally well tolerated; however, the efficacy of IADP was unknown in this population since most dogs received concurrent oral antimicrobials and/or surgery.

The Frequency of White Blood Cell and Temperature Events During Mechanical Ventilation and Their Association With Ventilator-Associated Events

2015 ◽  
Vol 32 (4) ◽  
pp. 273-277
Author(s):  
Hawa Edriss ◽  
Jeremy Whiting ◽  
Kenneth Nugent
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Patient Characteristics ◽  
Median Number ◽  
Normal Range ◽  
Cell Counts ◽  
Medical Intensive Care ◽  
White Blood Cell Counts ◽  
Wbc Count ◽  
Control Criteria

Background: Changes in white blood cell (WBC) counts and/or temperature could have important implications in patients on ventilators, but the frequency of these events is uncertain. Methods: We reviewed the medical records from 281 ventilation episodes in our medical intensive care unit to determine patient characteristics and the indications for ventilation. We determined the number of days during each ventilation episode in which the temperature (<96.8°F, >100.4°F) or WBC count (<4000/µL, >12 000/µL) was out of the normal range. Results: This study included 257 patients with a mean Acute Physiology and Chronic Health Evaluation 2 score of 13.5 ± 5.9 and a mean initial Pao2/Fio2 of 210 ± 110. The median number of ventilator days was 4 (interquartile range, 3-9). One hundred ninety-six of 275 eligible ventilator episodes (71.3%) had 1 or more temperature events, and 194 of 253 eligible ventilator episodes (76.7%) had 1 or more WBC events. Nineteen patients met the Center for Disease Control criteria for a ventilator-associated event (VAE). Twelve patients had an increased WBC count during the VAE period, and 11 had an increased temperature during this period. Conclusions: White blood cell counts and temperature events occur frequently in patients on ventilators and need evaluation but do not reliably identify patients with ventilator-associated complications.

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

Association Between White Blood Cell Counts and Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults: A Cross-Sectional Study

Angiology ◽  
2021 ◽  
pp. 000331972110211
Author(s):  
Buyun Jia ◽  
Chongfei Jiang ◽  
Yun Song ◽  
Chenfangyuan Duan ◽  
Lishun Liu ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Blood Cell ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
White Blood Cell ◽  
Pulse Wave ◽  
Final Analysis ◽  
Cross Sectional ◽  
Cell Counts ◽  
Wbc Count

Increased arterial stiffness is highly prevalent in patients with hypertension and is associated with cardiovascular (CV) risk. Increased white blood cell (WBC) counts may also be an independent risk factor for arterial stiffness and CV events. The aim of the study was to investigate the relationship between differential WBC counts and brachial-ankle pulse wave velocity (baPWV) in hypertensive adults. A total of 14 390 participants were included in the final analysis. A multivariate linear regression model was applied for the correlation analysis of WBC count and baPWV. Higher WBC counts were associated with a greater baPWV: adjusted β = 10 (95% CI, 8-13, P < .001). The same significant association was also found when WBC count was assessed as categories or quartiles. In addition, the effect of differential WBC subtypes, including neutrophil count and lymphocyte count on baPWV, showed the similar results. These findings showed that baPWV has positive associations with differential WBC counts in hypertensive adults.

scholarly journals Influence of platelet and white blood cell counts on major thrombosis – analysis from a patient registry in essential thrombocythemia

2016 ◽  
Vol 97 (6) ◽  
pp. 511-516 ◽  
Author(s):  
Veronika Buxhofer‐Ausch ◽  
Michael Steurer ◽  
Siegfried Sormann ◽  
Ernst Schloegl ◽  
Wolfgang Schimetta ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Essential Thrombocythemia ◽  
Patient Registry ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

scholarly journals White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58354 ◽  
Author(s):  
Nancy Babio ◽  
Núria Ibarrola-Jurado ◽  
Mònica Bulló ◽  
Miguel Ángel Martínez-González ◽  
Julia Wärnberg ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Cell ◽  
White Blood Cell ◽  
Risk Markers ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Predimed Study

scholarly journals Blood histamine levels (BHL) in infants and children with respiratory and non-respiratory diseases

2001 ◽  
Vol 10 (1) ◽  
pp. 7-11 ◽  
Author(s):  
C. Ponvert ◽  
L. Galoppin ◽  
J. Paupe ◽  
J. de Blic ◽  
M. Le Bourgeois ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Blood Cell ◽  
White Blood Cell ◽  
Infants And Children ◽  
Unknown Aetiology ◽  
Cell Counts ◽  
Acute Infections ◽  
Blood Histamine ◽  
White Blood Cell Counts ◽  
In Infants And Children

Background: Blood histamine levels are decreased after severe allergic reactions and in various chronic diseases.Aims: To study blood histamine levels in infants and children with acute infectious and non-infectious, non-allergic, disease.Methods: Blood histamine levels were investigated by a fluorometric method in infants and children admitted to hospital with bronchiolitis, non-wheezing bronchitis, acute infections of the urinary tract, skin and ear-nose-throat, gastroenteritis, or hyperthermia of unknown aetiology. Results of blood histamine levels and white blood cell counts were compared with those obtained for children recovering from benign non-infectious, non-allergic illnesses.Results: As compared with control children, white blood cell numbers were significantly increased in children with acute infections of the urinary tract, skin and ear-nose-throat, and were significantly decreased in children with gastroenteritis. Blood histamine levels were significantly lower in children with gastroenteritis and hyperthermia than in children with other diseases and control children. It was not possible to correlate blood histamine levels and the number of blood basophils.Conclusions: BHL are significantly decreased in infants and children with acute gastroenteritis and hyperthermia of unknown aetiology. The mechanisms responsible for the decrease in blood histamine levels in children with gastroenteritis and hyperthermia are discussed.

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