RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction

2017 ◽  
Vol 125 (08) ◽  
pp. 547-553 ◽  
Author(s):  
Danyan Chen ◽  
Xiaolong Huang ◽  
Song Lu ◽  
Huacong Deng ◽  
Hua Gan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Cognitive Function ◽  
Cerebral Infarction ◽  
Cognitive Dysfunction ◽  
Pathway Activation ◽  
Radiological Data ◽  
Function Impairment ◽  
Silent Cerebral Infarction ◽  
Signal Regulation ◽  
Regression Correlation

Abstract Aim To investigate the RBP4/Lp-PLA2/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI). Methods One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum RBP4 concentrations were determined by ELISA and protein expressions of Lp-PLA2 and Netrin-1 were determined by Western Blot. Results Compared with NSCI group, the cognitive function of patients in SCI group was impaired, the concentrations of RBP4 and the expressions of Lp-PLA2 and Netrin-1 increased (P<0.05). RBP4 concentrations were positively correlated with the cognitive dysfunction of SCI patients. Moreover, there existed a regression correlation between them. Conclusion RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with SCI and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA2/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI.

Silent cerebral infarction and cognitive function in middle-aged neurologically healthy subjects

2002 ◽  
Vol 105 (3) ◽  
pp. 179-184 ◽  
Author(s):  
S. Maeshima ◽  
H. Moriwaki ◽  
F. Ozaki ◽  
R. Okita ◽  
H. Yamaga ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cerebral Infarction ◽  
Healthy Subjects ◽  
Middle Aged ◽  
Silent Cerebral Infarction

Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride

2005 ◽  
Vol 21 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Yasuhiro Kawagoe ◽  
Takaharu Matsuda ◽  
Yoshihiko Ueda ◽  
Isao Ebihara ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Cerebral Infarction ◽  
Antiplatelet Drug ◽  
Silent Cerebral Infarction ◽  
Type 2 Diabetic

scholarly journals Silent cerebral infarction and cognitive function following TAVI: an observational two-centre UK comparison of the first-generation CoreValve and second-generation Lotus valve

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e022329 ◽  
Author(s):  
Tarique Al Musa ◽  
Akhlaque Uddin ◽  
Catherine Loveday ◽  
Laura E Dobson ◽  
Mark Igra ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cerebral Infarction ◽  
Verbal Memory ◽  
First Generation ◽  
Second Generation ◽  
Neurocognitive Performance ◽  
University Hospitals ◽  
Transcatheter Aortic Valve ◽  
Cerebral Mri ◽  
Silent Cerebral Infarction

ObjectiveTo compare the incidence of silent cerebral infarction and impact on cognitive function following transcatheter aortic valve implantation (TAVI) with the first-generation CoreValve (Medtronic, Minneapolis, Minnesota, USA) and second-generation Lotus valve (Boston Scientific, Natick Massachusetts, USA).DesignA prospective observational study comprising a 1.5 T cerebral MRI scan, performed preoperatively and immediately following TAVI, and neurocognitive assessments performed at baseline, 30 days and 1 year follow-up.SettingUniversity hospitals of Leeds and Leicester, UK.Patients66 (80.6±8.0 years, 47% male) patients with high-risk severe symptomatic aortic stenosis recruited between April 2012 and May 2015.Main outcome measuresIncidence of new cerebral microinfarction and objective decline in neurocognitive performance.ResultsAll underwent cerebral MRI at baseline and immediately following TAVI, and 49 (25 Lotus, 24 CoreValve) completed neurocognitive assessments at baseline, 30 days and 1 year. There was a significantly greater incidence of new cerebral microinfarction observed following the Lotus TAVI (23 (79%) vs 22 (59%), p=0.025) with a greater number of new infarcts per patient (median 3.5 (IQR 7.0) vs 2.0 (IQR 3.0), p=0.002). The mean volume of infarcted cerebral tissue per patient was equivalent following the two prostheses (p=0.166). More patients suffered new anterior (14 (48%) vs 2 (5%), p=0.001) and vertebrobasilar (15 (52%) vs 7 (19%), p=0.005) lesions following Lotus. Lotus was associated with a decline in verbal memory and psychomotor speed at 30 days. However, performance longitudinally at 1 year was preserved in all neurocognitive domains.ConclusionsThere was a higher incidence of silent cerebral microinfarction and a greater number of lesions per patient following Lotus compared with CoreValve. However, there was no objective decline in neurocognitive function discernible at 1 year following TAVI with either prosthesis.

scholarly journals Study on incidence of silent cerebral ischemia among diabetic nephropathy patients admitted in tertiary care hospital

2020 ◽  
Vol 8 (4) ◽  
pp. 1440
Author(s):  
P. M. Diggikar ◽  
P. K. Satpathy ◽  
Shubham Mishra ◽  
Kranthi Dandi
Keyword(s):  
Diabetic Nephropathy ◽  
Cerebral Ischemia ◽  
Cerebral Infarction ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Duration Of Diabetes ◽  
Media Thickness ◽  
Silent Cerebral Infarction ◽  
Silent Cerebral Ischemia

Abstract: Background: Diabetes accelerates the atherosclerotic process in blood vessels, leading to micro- and macro vascular complications, stroke being one of these. Carotid artery atherosclerosis in patients with Diabetic nephropathy is found to be associated with Silent cerebral infarction (SCI). Present study was carried to found any relationship between carotid intima media thickness and silent cerebral infarction in patients with type 2 diabetic nephropathy.Methods: The study was done in 50 DN patients admitted in medicine ward of tertiary care hospital. Subjects were evaluated based on detailed clinical data like symptoms, signs, and associated illnesses, general and systemic examination. Subjects were diagnosed with silent cerebral infarct based on MRI Findings. Each subject had undergone MRI to find out incidence of SCI.Results: Maximum (54%) was in age group of 61-70yrs and very few (6%) were below age of 50yrs. M: F was 1.6:1. Around 44% had duration of diabetes in 1-5yrs of duration and very few (6%) had diabetes >15yrs. On USG scan of carotid vessels it was found that 86% had increased carotid intimal media thickness either or side of vessel. On MRI brain there was incidence of silent cerebral ischemia among 30% study subjects.Conclusion: Both CIMT and SBI showed rise in incidence with corresponds to increase in age, duration of diabetes and urine albumin level among study subjects. 

scholarly journals Clinical study on cognitive function in silent cerebral infarction with diabetes mellitus.

Nosotchu ◽  
1997 ◽  
Vol 19 (5) ◽  
pp. 349-354
Author(s):  
Nagato Kuriyama ◽  
Toshiki Mizuno ◽  
Kenji Nakajima ◽  
Yoshihiro Kitagawa
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Study ◽  
Cognitive Function ◽  
Cerebral Infarction ◽  
Silent Cerebral Infarction

scholarly journals Efficacy of alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy with silent cerebral infarction

2017 ◽  
Vol 7 (5) ◽  
pp. 407-415 ◽  
Author(s):  
Danyan Chen ◽  
Xiaolong Huang ◽  
Hua Gan ◽  
Xiaogang Du ◽  
Song Lu ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Cerebral Infarction ◽  
Motor Imagery ◽  
Hyperbaric Oxygen ◽  
Silent Cerebral Infarction

Cognitive Dysfunction in Recovered Depressive Patients with Silent Cerebral Infarction

2002 ◽  
Vol 45 (1) ◽  
pp. 12-18 ◽  
Author(s):  
H. Yamashita ◽  
T. Fujikawa ◽  
I. Yanai ◽  
S. Morinobu ◽  
S. Yamawaki
Keyword(s):  
Cerebral Infarction ◽  
Cognitive Dysfunction ◽  
Silent Cerebral Infarction ◽  
Depressive Patients

Analysis of cognitive dysfunction with silent cerebral infarction: a prospective study in Chinese patients

2011 ◽  
Vol 27 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Jing Zhao ◽  
Huidong Tang ◽  
Jialan Sun ◽  
Baisong Wang ◽  
Shengdi Chen ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Prospective Study ◽  
Cognitive Dysfunction ◽  
Chinese Patients ◽  
Silent Cerebral Infarction ◽  
A Prospective Study

Arterial Stiffness, Cognitive Dysfunction and Adherence to Antihypertensive Agents. Is there a Link to Hypertensive Patients?

2020 ◽  
Vol 18 (4) ◽  
pp. 410-417 ◽  
Author(s):  
Rigas G. Kalaitzidis ◽  
Thalia Panagiotopoulou ◽  
Dimitrios Stagikas ◽  
Kosmas Pappas ◽  
Olga Balafa ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Arterial Stiffness ◽  
Cognitive Dysfunction ◽  
Antihypertensive Drugs ◽  
Patient Adherence ◽  
Antihypertensive Agents ◽  
Treatment Compliance ◽  
Poor Adherence ◽  
Large Artery ◽  
Adherence To Medication

:The incidence of hypertension (HTN) and its cardiovascular (CV) complications are increasing throughout the world. Blood pressure (BP) control remains unsatisfactory worldwide. Medical inertia and poor adherence to treatment are among the factors that can partially explain, why BP control rate remains low. The introduction of a method for measuring the degree of adherence to a given medication is now a prerequisite. Complex treatment regimes, inadequate tolerance and frequent replacements of pharmaceutical formulations are the most common causes of poor adherence. In contrast, the use of stable combinations of antihypertensive drugs leads to improved patient adherence.:We aim to review the relationships between arterial stiffness, cognitive function and adherence to medication in patients with HTN.:Large artery stiffening can lead to HTN. In turn, arterial stiffness induced by HTN is associated with an increased CV and stroke risk. In addition, HTN can induce disorders of brain microcirculation resulting in cognitive dysfunction. Interestingly, memory cognitive dysfunction leads to a reduced adherence to drug treatment. Compliance with antihypertensive treatment improves BP control and arterial stiffness indices. Early treatment of arterial stiffness is strongly recommended for enhanced cognitive function and increased adherence.

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