Morphological, functional and electrophysiological properties of human bone marrow-derived cells after 28 days under different cultivation conditions

2004 ◽  
Vol 52 (S 1) ◽  
Author(s):  
AJ Rastan ◽  
A Stein ◽  
A Schubert ◽  
J Garbade ◽  
H Aupperle ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cultivation Conditions ◽  
Electrophysiological Properties ◽  
Bone Marrow Derived Cells

scholarly journals Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury

2008 ◽  
Vol 295 (2) ◽  
pp. L285-L292 ◽  
Author(s):  
Janice M. Liebler ◽  
Carolyn Lutzko ◽  
Agnes Banfalvi ◽  
Dinithi Senadheera ◽  
Neema Aghamohammadi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lung Injury ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Reversible Inhibitor ◽  
Peptidase Activity ◽  
Immunodeficient Mice ◽  
Bone Marrow Derived Cells ◽  
Stem Cell Populations ◽  
Cxcr4 Axis

We studied the capacity of adult human bone marrow-derived cells (BMDC) to incorporate into distal lung of immunodeficient mice following lung injury. Immunodeficient NOD/SCID and NOD/SCID/β2microglobulin (β2M)nullmice were administered bleomycin (bleo) or saline intranasally. One, 2, 3 and 4 days after bleo or saline, human BMDC labeled with CellTracker Green CMFDA (5-chloromethylfluorescein diacetate) were infused intravenously. Retention of CMFDA+cells was maximal when delivered 4 days after bleo treatment. Seven days after bleo, <0.005% of enzymatically dispersed lung cells from NOD/SCID mice were CMFDA+, which increased 10- to 100-fold in NOD/SCID/β2Mnullmice. Preincubation of BMDC with Diprotin A, a reversible inhibitor of CD26 peptidase activity that enhances the stromal-derived factor-1 (SDF-1/CXCL12)/CXCR4 axis, resulted in a 30% increase in the percentage of CMFDA+cells retained in the lung. These data indicate that human BMDC can be identified in lungs of mice following injury, albeit at low levels, and this may be modestly enhanced by manipulation of the SDF-1/CXCR4 axis. Given the overall low number of human cells detected, methods to increase homing and retention of adult BMDC, and consideration of other stem cell populations, will likely be required to facilitate engraftment in the treatment of lung injury.

Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study

The Lancet ◽  
2003 ◽  
Vol 361 (9363) ◽  
pp. 1084-1088 ◽  
Author(s):  
Simon D Tran ◽  
Stanley R Pillemer ◽  
Amalia Dutra ◽  
A John Barrett ◽  
Michael J Brownstein ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Epithelial Cells ◽  
Analytical Study ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Buccal Epithelial Cells ◽  
Bone Marrow Derived Cells

Rotating three-dimensional dynamic culture of adult human bone marrow-derived cells for tissue engineering of hyaline cartilage

2009 ◽  
Vol 27 (4) ◽  
pp. 517-521 ◽  
Author(s):  
Shinsuke Sakai ◽  
Hajime Mishima ◽  
Tomoo Ishii ◽  
Hiroshi Akaogi ◽  
Tomokazu Yoshioka ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Marrow ◽  
Hyaline Cartilage ◽  
Three Dimensional ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Adult Human ◽  
Dynamic Culture ◽  
Bone Marrow Derived Cells

Valproic Acid Enhances iPSC Induction From Human Bone Marrow-Derived Cells Through the Suppression of Reprogramming-Induced Senescence

2015 ◽  
Vol 231 (8) ◽  
pp. 1719-1727 ◽  
Author(s):  
Xi Chen ◽  
Yingying Zhai ◽  
Dehai Yu ◽  
Jiuwei Cui ◽  
Ji-Fan Hu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Valproic Acid ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Bone Marrow Derived Cells

scholarly journals Activation of the germ-cell potential of human bone marrow-derived cells by a chemical carcinogen

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Chunfang Liu ◽  
Zhan Ma ◽  
Songtao Xu ◽  
Jun Hou ◽  
Yao Hu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Germ Cell ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Chemical Carcinogen ◽  
Cell Potential ◽  
Bone Marrow Derived Cells

Human bone marrow-derived cells: An attractive source to populate dermal substitutes

2008 ◽  
Vol 16 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Florence Fioretti ◽  
Corinne Lebreton-DeCoster ◽  
Farida Gueniche ◽  
Myriam Yousfi ◽  
Philippe Humbert ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Dermal Substitutes ◽  
Bone Marrow Derived Cells
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