Cardiovascular risk factors in prepubertal, pubertal and young adult patients with overweight or obesity: Effects of age, gender and degree of overweight evaluated in 14869 patients

Background: The Africa Middle East (AfME) Cardiovascular Epidemiological (ACE) study demonstrated that cardiovascular risk factors are highly prevalent among relatively young adult outpatients attending general practice clinics across AfME regions.Objective: Based on the broader AfME estimates from the ACE Study, this sub-analysis evaluated the prevalence of cardiovascular risk factors in the United Arab Emirates (UAE), particularly in rural and urban cohorts attending general practice clinics.Methods: Data from the cross-sectional ACE study were used: stable, adult outpatients attending general practice clinics in the UAE. Prevalence of six CV risk factors were analyzed: hypertension, diabetes, dyslipidemia, obesity, smoking, abdominal obesity. Rural populations were defined as living >50km from urban centers, or lack of transportation.Results: In this cohort of 495 patients (aged 45.1 years; 49.8% female) from the UAE, a high prevalence of abdominal obesity (71.5%) and dyslipidemia (74.0%) was found. Nearly half of patients had hypertension (43.0%) and one-third diabetes (32.4%). Nearly all outpatients (92.9%) had ≥1 modifiable risk factor (74.9% had ≥1, 59.7% had ≥3). Observations were similar by gender, and across urban and rural centers. Many outpatients with pre-existing hypertension or dyslipidemia did not meet recognized blood pressure or low-density lipoprotein cholesterol goals.Conclusions: Cardiovascular risk factors are prevalent among relatively young adult, clinically stable outpatients attending outpatient clinics across the UAE. These findings support targeted screening of outpatients visiting a general practitioner, which may provide opportunity for early discovery and ongoing management of risk factors, including recommending lifestyle changes. The ACE trial is registered under NCT01243138.

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The Association Between Hypertension and Other Cardiovascular Risk Factors in Young Adult African Americans

Journal of Clinical Hypertension ◽

10.1111/j.1524-6175.2002.01211.x ◽

2002 ◽

Vol 4 (1) ◽

pp. 17-22 ◽

Cited By ~ 11

Author(s):

William C. Borde-Perry ◽

Kimberly L. Campbell ◽

Kevin H. Murtaugh ◽

Samuel Gidding ◽

Bonita Falkner

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Young Adult ◽

African Americans ◽

Cardiovascular Risk Factors

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Poor control and management of cardiovascular risk factors among Albanian diabetic adult patients

Primary Care Diabetes ◽

10.1016/j.pcd.2007.04.009 ◽

2007 ◽

Vol 1 (2) ◽

pp. 81-86 ◽

Cited By ~ 4

Author(s):

F. Toti ◽

G. Bejtja ◽

K. Hoti ◽

E. Shota ◽

F. Agaçi

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Adult Patients ◽

Poor Control ◽

Control And Management

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Cardiovascular risk factors in adult patients with multisystem Langerhans-cell histiocytosis: evidence of glucose metabolism abnormalities

QJM ◽

10.1093/qjmed/hcm118 ◽

2007 ◽

Vol 101 (1) ◽

pp. 31-40 ◽

Cited By ~ 10

Author(s):

K.I. Alexandraki ◽

P. Makras ◽

A.D. Protogerou ◽

K. Dimitriou ◽

A. Stathopoulou ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Glucose Metabolism ◽

Cardiovascular Risk Factors ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Adult Patients

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Cardiovascular risk factors in young male adults: impact of physical activity and parental education

Central Asian Journal of Global Health ◽

10.5195/cajgh.2013.44 ◽

2013 ◽

Vol 2 (1) ◽

Author(s):

Serap Çuhadar ◽

Ayşenur Atay ◽

Gülcan Sağlam ◽

Mehmet Köseoğlu ◽

Levent Çuhadar

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Risk ◽

Young Adult ◽

Lipid Profile ◽

Cardiovascular Risk Factors ◽

Household Income ◽

Parental Education ◽

Smoking Status ◽

Adult Males

Background: This study was conducted to assess whether choices of physical activity, smoking status, and parental education and income were correlated with the health status of young adult males which are important for preventive health policy. Methods: 491 18-29-year old males from lower socioeconomical districts in Turkey participated in this study. Information about demographic characteristics, parental education, household income, smoking status, and physical activity was obtained by means of a standardized questionnaire. BMI and metabolic parameters (serum lipid profile) were assessed.Results: Mean total cholesterol, LDL, HDL and triglyceride levels were in the normal range. The physically active group displayed a better lipid profile. No relationship was found between parental education and serum lipids. Smoking was slightly correlated with household income (r=103, p=0.022).Conclusion: Young adult males who participate in relatively high levels of physical activity are at lower CHD risk than less active ones. The present study also showed that lower socioecnomic status does not always correlate with higher levels of cardiovascular risk factors. In conclusion, data supports that while family history cannot be changed, HDL levels can be modulated by lifestyle factors as in other populations and that with the determined benefits of increasing physical activity and thus, HDL levels, policy reform in schools to promote physical activity are warranted.

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Lasmiditan is an effective acute treatment for migraine

Neurology ◽

10.1212/wnl.0000000000006641 ◽

2018 ◽

Vol 91 (24) ◽

pp. e2222-e2232 ◽

Cited By ~ 92

Author(s):

Bernice Kuca ◽

Stephen D. Silberstein ◽

Linda Wietecha ◽

Paul H. Berg ◽

Gregory Dozier ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Migraine Attack ◽

Acute Treatment ◽

Adult Patients ◽

Electronic Diary ◽

Double Blind ◽

Bothersome Symptom ◽

Headache Pain

ObjectiveTo assess the efficacy and safety of lasmiditan in the acute treatment of migraine.MethodsAdult patients with migraine were randomized (1:1:1) to a double-blind dose of oral lasmiditan 200 mg, lasmiditan 100 mg, or placebo and were asked to treat their next migraine attack within 4 hours of onset. Over 48 hours after dosing, patients used an electronic diary to record headache pain and the presence of nausea, phonophobia, and photophobia, one of which was designated their most bothersome symptom (MBS).ResultsOf the 1,856 patients who treated an attack, 77.9% had ≥1 cardiovascular risk factors in addition to migraine. Compared with placebo, more patients dosed with lasmiditan 200 mg were free of headache pain at 2 hours after dosing (32.2% vs 15.3%; odds ratio [OR] 2.6, 95% confidence interval [CI] 2.0–3.6, p< 0.001), similar to those dosed with lasmiditan 100 mg (28.2%; OR 2.2, 95% CI 1.6–3.0, p< 0.001). Furthermore, compared with those dosed with placebo, more patients dosed with lasmiditan 200 mg (40.7% vs 29.5%; OR 1.6, 95% CI 1.3–2.1, p< 0.001) and lasmiditan 100 mg (40.9%; OR 1.7, 95% CI, 1.3–2.2, p< 0.001) were free of their MBS at 2 hours after dosing. Adverse events were mostly mild or moderate in intensity.ConclusionsLasmiditan dosed at 200 and 100 mg was efficacious and well tolerated in the treatment of acute migraine among patients with a high level of cardiovascular risk factors.ClinicalTrials.gov identifierNCT02439320.Classification of evidenceThis study provides Class I evidence that for adult patients with migraine, lasmiditan increases the proportion of subjects who are headache pain free at 2 hours after treating a migraine attack.

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