Application of Neuronavigation System to Brain Tumor Surgery with Clinical Experience of 420 Cases

Abstract OBJECTIVE To integrate spatial three-dimensional information concerning the pyramidal tracts into a customized system for frameless neuronavigation during brain tumor surgery. METHODS Four consecutive patients with intracranial tumors in eloquent areas underwent diffusion-weighted and anatomic magnetic resonance imaging studies within 48 hours before surgery. Diffusion-weighted datasets were merged with anatomic data for navigation purposes. The pyramidal tracts were segmented and reconstructed for three-dimensional visualization. The reconstruction results, together with the fused-image dataset, were available during surgery in the environment of a customized neuronavigation system. RESULTS In all four patients, the combination of reconstructed data and fused images was a helpful additional source of information concerning the tumor seat and topographical interaction with the pyramidal tract. In two patients, intraoperative motor cortex stimulation verified the tumor seat with regard to the precentral gyrus. CONCLUSION Diffusion-weighted magnetic resonance imaging allows individual estimation of large fiber tracts applicable as important information in intraoperative neuronavigation and in planning brain tumor resection. A three-dimensional representation of fibers associated with the pyramidal tract during brain tumor surgery is feasible with the presented technique and is a helpful adjunct for the neurosurgeon. The main drawbacks include the length of time required for the segmentation procedure, the lack of direct intraoperative control of the pyramidal tract position, and brain shift. However, mapping of large fiber tracts and its intraoperative use for neuronavigation have the potential to increase the safety of neurosurgical procedures and to reduce surgical morbidity.

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STMO-14 Clinical experience of brain tumor surgery using middleware “OPeLiNK”

Neuro-Oncology Advances ◽

10.1093/noajnl/vdab159.049 ◽

2021 ◽

Vol 3 (Supplement_6) ◽

pp. vi13-vi13

Author(s):

Yu Fujii ◽

Toshihiro Ogiwara ◽

Tetsuya Goto ◽

Yoshihiro Muragaki ◽

Kazuhiro Hongo ◽

...

Keyword(s):

Brain Tumor ◽

Operating Room ◽

Clinical Experience ◽

Extent Of Resection ◽

Biological Information ◽

Histopathological Diagnosis ◽

Navigation Systems ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

Operation Room

Abstract PURPOSE The removal of brain tumors requires not only imaging information such as MRI and navigation systems, but also a variety of other information such as neurological function and biological information. To integrate this information, a novel operating room, “Smart Cyber Operating Theater (SCOT)”, which connects the medical devices in the operating room via a network has developed. In this SCOT, the intraoperative information is time-synchronized, recorded, and stored by the middleware “OPeLiNK”. Clinical experience of brain tumor surgery using OPeLiNK in our institute is reported. Methods Brain tumor surgeries performed at SCOT, which had been started since July 2018, was enrolled. In all surgeries intraoperative information was integrated by OPeLiNK. Surgical procedure was discussed between main surgeon and supervising surgeon in the Strategy Desk through OPeLiNK intraoperatively, if necessary. Clinical and radiological data from patients who underwent resection at SCOT were analyzed retrospectively. Results Sixty patients were involved. Histopathological diagnosis was glioma in 29 patients, pituitary adenoma in 29 patients, acoustic tumor in 1 patient and intravascular lymphoma in 1 patient. Intraoperative discussion with Strategy Desk through OPeLiNK was useful for not only surgeons but also for medical staff in operation room. Advice for extent of resection and craniotomy from Strategy Desk was conducted by OPeLiNK using conversation and drawing. Intraoperative comment was useful for postoperative review. OPeLiNK, which display multiple intraoperative information, was also used at postoperative conference. Conclusion We have reported clinical experience with OPeLiNK for brain tumor surgery in our institute. OPeLiNK was useful for not only sharing intraoperative information with doctors outside the operation room but also postoperative review and education for young doctors.

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Machine Learning Algorithm to Predict Early Complications after Brain Tumor Surgery

10.1055/s-0038-1660728 ◽

2018 ◽

Author(s):

C.H.B. van Niftrik ◽

F. van der Wouden ◽

V. Staartjes ◽

J. Fierstra ◽

M. Stienen ◽

...

Keyword(s):

Machine Learning ◽

Brain Tumor ◽

Learning Algorithm ◽

Machine Learning Algorithm ◽

Tumor Surgery ◽

Early Complications ◽

Brain Tumor Surgery

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Optic nerve sheath diameter (ONSD) in sovratentorial brain tumor surgery: an option for non invasive raised ICP detection and management. Preliminary results and feasibility assessment

10.26226/morressier.58f5b031ab9a5f002a4cadae ◽

2017 ◽

Author(s):

Raffaele Aspide

Keyword(s):

Brain Tumor ◽

Optic Nerve ◽

Optic Nerve Sheath Diameter ◽

Optic Nerve Sheath ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

Preliminary Results ◽

Feasibility Assessment ◽

Non Invasive ◽

Nerve Sheath

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Faculty Opinions recommendation of A comparison of 3% hypertonic saline and mannitol for brain relaxation during elective supratentorial brain tumor surgery.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2647974.2692061 ◽

2010 ◽

Author(s):

Luzius A Steiner ◽

Christoph Burkhart

Keyword(s):

Brain Tumor ◽

Hypertonic Saline ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

Brain Relaxation

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Role of Perioperative Factor XIII in Intracerebral Hemorrhage after Brain Tumor Surgery: A Prospective Study

SSRN Electronic Journal ◽

10.2139/ssrn.3398543 ◽

2019 ◽

Author(s):

Estela Val Jordan ◽

Agustín Nebra Puertas ◽

Juan Casado Pellejero ◽

Maria Dolores Vicente Gordo ◽

Concepción Revilla López ◽

...

Keyword(s):

Brain Tumor ◽

Intracerebral Hemorrhage ◽

Prospective Study ◽

Factor Xiii ◽

Tumor Surgery ◽

Brain Tumor Surgery ◽

A Prospective Study

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Virtual Reality during Brain Mapping for Awake-Patient Brain Tumor Surgery: Proposed Tasks and Domains to Test

World Neurosurgery ◽

10.1016/j.wneu.2021.05.118 ◽

2021 ◽

Author(s):

Gennadiy A. Katsevman ◽

Walter Greenleaf ◽

Ricardo García-García ◽

Maria Victoria Perea ◽

Valentina Ladera ◽

...

Keyword(s):

Virtual Reality ◽

Brain Tumor ◽

Brain Mapping ◽

Tumor Surgery ◽

Awake Patient ◽

Brain Tumor Surgery

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MS-1 Surgical strategy for brain tumor based on molecular and functional connectomics profiles

Neuro-Oncology Advances ◽

10.1093/noajnl/vdaa143.008 ◽

2020 ◽

Vol 2 (Supplement_3) ◽

pp. ii2-ii2

Author(s):

Tatsuya Abe

Keyword(s):

Overall Survival ◽

Brain Tumor ◽

Standard Procedure ◽

Awake Craniotomy ◽

Surgical Strategy ◽

Neurological Deficits ◽

Cortical Mapping ◽

Photodynamic Diagnosis ◽

Tumor Surgery ◽

Brain Tumor Surgery

Abstract It is reported that the development of new perioperative motor deficits was associated with decreased overall survival despite similar extent of resection and adjuvant therapy. The maximum safe resection without any neurological deficits is required to improve overall survival in patients with brain tumor. Surgery is performed with various modalities, such as neuro-monitoring, photodynamic diagnosis, neuro-navigation, awake craniotomy, intraoperative MRI, and so on. Above all, awake craniotomy technique is now the standard procedure to achieve the maximum safe resection in patients with brain tumor. It is well known that before any treatment, gliomas generate globally (and not only focally) altered functional connectomics profiles, with various patterns of neural reorganization allowing different levels of cognitive compensation. Therefore, perioperative cortical mapping and elucidation of functional network, neuroplasticity and reorganization are important for brain tumor surgery. On the other hand, recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. Then, we aimed to identify these biomarkers in pre-operative and/or intra-operative periods, using liquid biopsy, immunostaining and various PCR methods including rapid genotyping assay. In this presentation, we would like to demonstrate our surgical strategy based on molecular and functional connectomics profiles.

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