Thyroid Hormone Binding Inhibitor (THBI) Mainly Associated with Serum Oleic Acid Concentration

Abstract. Several thyroid hormone binding inhibitors have been described in nonthyroid illness. One of the major inhibitors, oleic acid, is present in excess amounts in sera of patients with nonthyroid illness. In this study, we demonstrated that oleic acid inhibited the cAMP accumulation of thyroid plasma membrane activated by thyrotropin at 50 μmol/l and higher concentrations. In the presence of albumin, oleic acid significantly inhibited the cAMP accumulation of plasma membrane activated by thyrotropin at 2.4 mmol/l (P < 0.01 when the albumin concentration was 40 g/l and pH was 7.4; P < 0.001 when the albumin concentration was 20 g/l and pH was 7.2). These findings suggest that in nonthyroid illness, especially at a low albumin concentration and low blood pH, a high oleic acid concentration may influence the thyroid function directly in addition to inhibiting the thyroid hormone binding to serum protein. Oleic acid also could inhibit 5′-guanylylimidodiphosphate- and forskolin-induced cAMP production in thyroid plasma membranes. Therefore, the inhibiting effect of oleic acid may be through the action of oleic acid on the catalytic unit of the hormone-sensitive adenylate cyclase system.

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The effect of oleic acid concentration on the optical, structural, and magnetic properties of cobalt oxide nanostructures prepared by ultrasound-assisted method

Inorganic and Nano-Metal Chemistry ◽

10.1080/24701556.2017.1357579 ◽

2018 ◽

Vol 48 (1) ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Yashar Azizian-Kalandaragh ◽

Roya Shokrani-Havigh

Keyword(s):

Magnetic Properties ◽

Oleic Acid ◽

Cobalt Oxide ◽

Acid Concentration ◽

Oxide Nanostructures ◽

Oleic Acid Concentration ◽

Structural And Magnetic Properties ◽

Ultrasound Assisted

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Developmental Changes in Acyl‐Composition of Soybean Seed Selected for High Oleic Acid Concentration 1

Crop Science ◽

10.2135/cropsci1984.0011183x002400060003x ◽

1984 ◽

Vol 24 (6) ◽

pp. 1016-1019 ◽

Cited By ~ 4

Author(s):

Brett F. Carver ◽

Richard F. Wilson ◽

Joseph W. Burton

Keyword(s):

Oleic Acid ◽

Acid Concentration ◽

Soybean Seed ◽

Developmental Changes ◽

High Oleic Acid ◽

High Oleic ◽

Acyl Composition ◽

Oleic Acid Concentration

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Inheritance of Increased Oleic Acid Concentration in High-Erucic Acid Ethiopian Mustard

Crop Science ◽

10.2135/cropsci2003.1060 ◽

2003 ◽

Vol 43 (1) ◽

pp. 106 ◽

Cited By ~ 11

Author(s):

Leonardo Velasco ◽

José M. Fernández-Martínez ◽

Antonio De Haro

Keyword(s):

Oleic Acid ◽

Erucic Acid ◽

Acid Concentration ◽

High Erucic Acid ◽

Ethiopian Mustard ◽

Oleic Acid Concentration

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The effect of oleic acid on the synthesis of Fe3−xO4 nanoparticles over a wide size range

Physical Chemistry Chemical Physics ◽

10.1039/c5cp03395k ◽

2015 ◽

Vol 17 (41) ◽

pp. 27373-27379 ◽

Cited By ~ 25

Author(s):

Carlos Moya ◽

Xavier Batlle ◽

Amílcar Labarta

Keyword(s):

Thermal Decomposition ◽

Oleic Acid ◽

Structural Properties ◽

Acid Concentration ◽

Size Range ◽

Benzyl Ether ◽

Oleic Acid Concentration ◽

Wide Size Range

This work reports on the effect of the oleic acid concentration on the magnetic and structural properties of Fe3−xO4 nanoparticles synthesized by thermal decomposition of Fe(acac)3 in benzyl-ether.

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